Jintao Guan

ORCID: 0000-0003-4113-2360
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About
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Research Areas
  • SARS-CoV-2 and COVID-19 Research
  • RNA Interference and Gene Delivery
  • COVID-19 Clinical Research Studies
  • Advanced biosensing and bioanalysis techniques
  • Long-Term Effects of COVID-19
  • Microbial Metabolic Engineering and Bioproduction
  • Protein purification and stability
  • Virus-based gene therapy research
  • Rheumatoid Arthritis Research and Therapies
  • Polysaccharides Composition and Applications
  • Pancreatic and Hepatic Oncology Research
  • Histone Deacetylase Inhibitors Research
  • Anaerobic Digestion and Biogas Production
  • Adenosine and Purinergic Signaling
  • Traditional Chinese Medicine Studies
  • Microfluidic and Bio-sensing Technologies
  • Polysaccharides and Plant Cell Walls
  • Proteins in Food Systems
  • Microbial Metabolites in Food Biotechnology
  • Diabetes Treatment and Management
  • Environmental remediation with nanomaterials
  • Biopolymer Synthesis and Applications
  • CAR-T cell therapy research
  • HIV-related health complications and treatments
  • 3D Printing in Biomedical Research

Taizhou First People's Hospital
2021-2023

Wuhan Polytechnic University
2018-2023

Zhejiang University
2018

Zhejiang University of Technology
2016-2018

City University of Hong Kong
2017

City University of Hong Kong, Shenzhen Research Institute
2017

Autophagy is a fundamental cellular degradation process which essential for cell homeostasis, and dysfunctional autophagy has been associated with variety of human diseases, such as cancer. Several chemical modulators have applied in number preclinical or clinical trials against these related especially Small molecule vacuolin-1 potently reversibly inhibits both endosomal-lysosomal trafficking autophagosome-lysosome fusion, yet the molecular mechanisms underlying mediated inhibition remain...

10.3390/molecules22060891 article EN cc-by Molecules 2017-05-27

The dynamic formation of alginate droplets containing Lactobacillus buchneri cells by the microtube dripping method was investigated experimentally. Supermacroporous cell-entrapped cryogel beads were then fabricated via cryo-cross-linking these cell-loaded under freezing conditions and used as biocatalysts for synthesis phenyllactic acid bioconversion. evolution interface, velocity, microthread length, droplet diameter during process studied high-speed imaging together with computational...

10.1021/acs.iecr.8b00831 article EN Industrial & Engineering Chemistry Research 2018-05-11

Traditional Chinese medicine (TCM) has been proven to be an effective complementary therapy in treating rheumatoid arthritis (RA). The cold pattern and the heat were two main TCM patterns for RA, which is crucial treatment. characterized by fear of wind, joint pain with a thin white tongue coating can relieved hot herbs. In contrast, patients suffer from severe yellow coating, red swelling skin high temperature cooling herbs.We aimed classify RA cluster analysis factor analysis. Moreover, we...

10.1016/j.heliyon.2023.e13439 article EN cc-by-nc-nd Heliyon 2023-02-01

This meta-analysis aims to assess the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies on COVID-19.Relevant literatures about GM-CSF antibody treatment in COVID-19 patients were searched from PubMed, Cochrane Library, Embase, Google scholar, Baiduscholar databases outbreak December 2019 until 1 January 2021. The primary outcomes included death, intensive care unit (ICU) admission risk, ventilation requirement, secondary infection.A total 12 eligible...

10.1177/20406223211039699 article EN cc-by-nc Therapeutic Advances in Chronic Disease 2021-01-01

Histone deacetylase 4 (HDAC4) modulates immunity, inflammation, and osteoblast differentiation to engage in rheumatoid arthritis (RA) etiology. This study aimed evaluate the HDAC4 longitudinal change its relationship with clinical features outcomes RA patients.Eighty-three patients were enrolled. Their serum level was detected by ELISA at baseline (W0), week (W) 4, W12, W24 after treatment. divided into response or non-response, low disease activity (LDA) non-LDA, remission non-remission...

10.1002/jcla.24594 article EN cc-by-nc-nd Journal of Clinical Laboratory Analysis 2022-07-06

Abstract Objective We performed a meta-analysis in order to determine safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies on COVID-19. Methods searched from the Cochrane Library, PubMed, Embase, biorxiv and medrxiv databases beginning COVID-19 outbreak December 1, 2019 until August 29, 2021. The primary outcomes included death, incidence invasive mechanical ventilation (IMV), requirement, secondary infection. Results 6 eligible literature involving 1501 patients...

10.1101/2022.01.07.22268878 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-01-10

Abstract In this study, the effect of biochar supported nano‐zero valent iron (nZVI/BC) on anaerobic digestion sulfate wastewater including methane yield, total volatile fatty acids, COD balance, sulfur variation (Fe 2+ ) and microbial community structure was investigated by a batch‐scale experiment. The results showed that nZVI/BC could effectively maintain stability even at high concentration. At SO 4 2− /COD = 0.1 with 2 g nZVI/BC, maximum yield ( B max production rate R were obtained...

10.1002/ep.14187 article EN Environmental Progress & Sustainable Energy 2023-05-17

Objective: Liraglutide are associated with a decreased risk of fracture among Type 2 Diabetes Mellitus Patients (T2DM) but the mechanism is unclear, effect liraglutide on Bone Mineral Density (BMD) and Turnover Markers (BTMs) were taken into consideration.

10.26502/acbr.50170231 article EN Archives of Clinical and Biomedical Research 2022-01-01
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