A5074718723- Corneal Surgery and Treatments
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Ocular Surface and Contact Lens
- Optical Coherence Tomography Applications
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Renal and related cancers
- Cutaneous Melanoma Detection and Management
- Circular RNAs in diseases
- Pluripotent Stem Cells Research
- Photoacoustic and Ultrasonic Imaging
- Ocular Disorders and Treatments
- Kruppel-like factors research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Polymer Surface Interaction Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced X-ray and CT Imaging
- Innovative Microfluidic and Catalytic Techniques Innovation
University of Illinois Chicago
2020-2025
University College London
2014-2024
University of Michigan
2020-2023
University of Illinois System
2021
Visual Sciences (United States)
2021
University of Illinois Urbana-Champaign
2021
Harvard University
2017-2018
Massachusetts Institute of Technology
2017-2018
Harvard–MIT Division of Health Sciences and Technology
2017-2018
Innovation Research Center
2017-2018
Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability selectively transfer biomolecules specific cell types. EVs, composed proteins, nucleic acids, and lipids, taken up by cells affect variety signaling cascades. Research the field has primarily focused on stem with particular focus mesenchymal cells, for potential therapeutic benefits. Recently, tissue-specific EVs or type-specific...
To develop biomimetic three-dimensional (3D) tissue constructs for drug screening and biological studies, engineered blood vessels should be integrated into the to mimic administration process in vivo. The development of perfusable vascularized 3D studying through an endothelial layer remains area intensive research. Here, we report a simple liver model study toxicity incorporation layer. Using sacrificial bioprinting technique, hollow microchannel was successfully fabricated construct...
Abstract Purpose Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) have been demonstrated to possess great potential in preclinical models. An efficient biomanufacturing platform is necessary for scale up production clinical therapeutic applications. The aim of this study investigate the differences neuro-regenerative properties MSC-derived EVs generated 2D versus 3D culture systems. Method Human bone marrow MSCs (BM-MSCs) were cultured monolayer and bioreactor...
Abstract Human cortical organoids (hCOs), derived from human induced pluripotent stem cells (iPSCs), provide a platform to interrogate mechanisms of brain development and diseases in complex three- dimensional tissues. However, current hCO methods lack important non-neural tissues, such as the surrounding meningeal layer, that have been shown be essential for normal corticogenesis development. Here, we first generated hCOs single rosette create more homogenous with consistent size around 250...
Extracellular vesicles (EVs), a diverse group of cell-derived exocytosed particles, are pivotal in mediating intercellular communication due to their ability selectively transfer biomolecules specific cell types. EVs, composed proteins, nucleic acids, and lipids, taken up by cells affect variety signaling cascades. Research the field has primarily focused on stem-cell derived with particular focus mesenchymal stem cells, for potential therapeutic benefits. Recently, tissue EVs or type...
Abstract Background Optical coherence tomography ( OCT ) is a promising imaging modality for skin cancer diagnosis. However, this capability has been hindered by the low contrast between normal and neoplastic tissue. To overcome limitation, gold nanoparticles have used to enhance in images are topically administered reduce risk of systematic side effects associated with intravenous injection. ensure efficient penetration distribution nanoparticles, an enhanced delivery strategy required. In...
Abstract Optical coherence tomography (OCT), with a high‐spatial resolution (<10 microns), intermediate penetration depth (~1.5 mm) and volumetric imaging capability is great candidate to be used as diagnostic‐assistant modality in dermatology. At this time, the accuracy of OCT for melanoma detection lower than anticipated. In letter, we studied first use novel contrast agent consist ultra‐small nanoparticles conjugated biomarker improve differentiation cells from nonmelanoma cells,...
Biological systems exchange information often with chemical signals. Here, we demonstrate the delivery of a fluorescent label using bioelectronic trigger. Acid-sensitive microparticles release fluorescin diacetate upon low pH induced by device. Cardiac fibroblast cells (CFs) uptake diacetate, which transforms into fluorescein and emits signal. This proof-of-concept triggered may be used in future for real-time programming control cell systems.
Abstract To compare the effects of two decellularization protocols on characteristics fabricated COrnea Matrix (COMatrix) hydrogels. Porcine corneas were decellularized with Detergent (De) or Freeze–Thaw (FT)-based protocols. DNA remnant, tissue composition and α-Gal epitope content measured. The effect α-galactosidase residue was assessed. Thermoresponsive light-curable (LC) hydrogels from characterized turbidimetric, light-transmission rheological experiments. cytocompatibility...
CD34+ cells hold significant promise in regenerative medicine and the treatment of various vascular degenerative diseases primarily because their ability to regenerate differentiate into cell types. These can be derived from embryonic stem (ESCs), induced pluripotent (iPSCs), or adult like blood bone marrow, endothelial, hematopoietic, myeloid, other However, characteristics vary based on source, making detailed definitions essential for specific therapeutic applications. In this study, it...
There are a number of different stem cell sources that have the potential to be used as therapeutics in vascular degenerative diseases. On one hand, there so called endothelial progenitor cells (EPCs), which typically derived from adult blood. They carry marker CD34, but true nature and definition EPCs is still controversial. other embryonic precursors (PECs), also express can differentiated (ESCs) or induced pluripotent (iPSCs) vitro. In this study, it was aimed compare these two CD34...