A5003231514- Innovative Microfluidic and Catalytic Techniques Innovation
- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Nanofabrication and Lithography Techniques
- Erythrocyte Function and Pathophysiology
- Analytical Chemistry and Sensors
- Photosynthetic Processes and Mechanisms
- Blood properties and coagulation
- Microtubule and mitosis dynamics
- Carbon Nanotubes in Composites
- Enzyme Production and Characterization
- Bacteriophages and microbial interactions
- Microfluidic and Bio-sensing Technologies
- Graphene and Nanomaterials Applications
- Cell Image Analysis Techniques
- Lipid Membrane Structure and Behavior
- Chemotherapy-induced cardiotoxicity and mitigation
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
ETH Zurich
2024
Brigham and Women's Hospital
2017-2021
Harvard University
2017-2021
Massachusetts Institute of Technology
2017-2021
Harvard–MIT Division of Health Sciences and Technology
2017-2021
Swiss Federal Laboratories for Materials Science and Technology
2016-2019
Innovation Research Center
2017
To develop biomimetic three-dimensional (3D) tissue constructs for drug screening and biological studies, engineered blood vessels should be integrated into the to mimic administration process in vivo. The development of perfusable vascularized 3D studying through an endothelial layer remains area intensive research. Here, we report a simple liver model study toxicity incorporation layer. Using sacrificial bioprinting technique, hollow microchannel was successfully fabricated construct...
Cardiotoxicity is one of the most serious side effects cancer chemotherapy. Current approaches to monitoring chemotherapy-induced cardiotoxicity (CIC) as well model systems that develop in vivo or vitro CIC platforms fail notice early signs CIC. Moreover, breast (BC) patients with preexisting cardiac dysfunctions may lead different incident levels Here, a presented for investigating where not only induced pluripotent stem cell (iPSC)-derived tissues are interacted BC on dual-organ platform,...
Abstract The dynamics of cellular membrane tension and its role in mechanosensing, which is the ability cells to respond physical stimuli, remain incompletely understood, mainly due lack appropriate tools. Here, we report a force-controlled nanopipette-based method that combines fluidic force microscopy with fluorescence imaging for precise manipulation while monitoring impact on single-cell mechanosensitivity. nanopipette enables control indentation imposed cell cortex as well aspiration...
Abstract The mechanotransduction process relies on the interaction of mechanical and biochemical cues, transmitting cellular forces to intracellular organelles activate pathways elicit responses. This involves mechanoresponsive components like actin filaments, microtubules (MTs), lamin meshwork. Fluidic force microscopy (FluidFM), a force-controlled micropipette allows for manipulation intact cells mechanically chemically, providing novel approach study mechanotransmission in situ . FluidFM...
Functional nanoparticles are valuable materials for energy production, bioelectronics, and diagnostic devices. The combination of biomolecules with nanosized material produces a new hybrid properties that can exceed the ones single components. Hematite is widely available has found application in various sectors such as sensing solar production. We report single-step immobilization process based on affinity achieved by genetically engineering protein interest to carry hematite-binding...
Abstract By applying a slow curing process, we show that biomolecules can be incorporated via simple process as liquid stable phases inside polydimethylsiloxane (PDMS) matrix. The is carried out under mild conditions with regards to temperature, pH and relative humidity, thus suitable for application biological entities. Fluorescence enzymatic activity measurements the biochemical properties of proteins enzyme tested are preserved, without loss due adsorption at liquid-polymer interface....
Abstract Controlled placement of single cells, spheroids and organoids is important for in vitro research, especially bottom-up biology lab-on-a-chip organ-on-a-chip applications. This study utilised FluidFM technology order to automatically pick place neuronal cells. Both cells interest could be selected using light microscopy or fluorescent staining. A process flow was developed pattern these neurons on flat surfaces, as well deposit them into polydimethylsiloxane microstructures...
In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co-workers develop a model for investigating chemotherapy-induced cardiotoxicity where induced pluripotent stem cell-derived cardiac tissues are interacted with breast cancer on dual-organ platform. Using electrochemical immuno-aptasensors to monitor cell-secreted multiple biomarkers, the proposed platform could be potentially suitable early detection prediction of in individual patients.
By applying a slow curing process, we show that biomolecules can be incorporated via simple process as liquid stable phases inside polydimethylsiloxane (PDMS) matrix. The is carried out under mild conditions with regards to temperature, pH and relative humidity, thus suitable for application biological entities. Fluorescence enzymatic activity measurements, the biochemical properties of proteins enzyme tested are preserved, without loss due adsorption at liquid-polymer interface. Protected...