A5046353626- Treatment of Major Depression
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Ferroptosis and cancer prognosis
- Antibiotic Use and Resistance
- Cancer-related Molecular Pathways
- Cancer therapeutics and mechanisms
- Anesthesia and Neurotoxicity Research
- Receptor Mechanisms and Signaling
- Genetic factors in colorectal cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- DNA Repair Mechanisms
- Food Quality and Safety Studies
- Gastric Cancer Management and Outcomes
- Peripheral Neuropathies and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Central Venous Catheters and Hemodialysis
- Parkinson's Disease and Spinal Disorders
- Vascular Tumors and Angiosarcomas
- Synthesis of Organic Compounds
- Ubiquitin and proteasome pathways
- Renal function and acid-base balance
- Salivary Gland Disorders and Functions
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
Mackay Memorial Hospital
2009-2023
Mackay Medical College
2014-2020
Cairns Hospital
2020
Taipei Medical University
2014-2017
Mackay Junior College of Medicine, Nursing and Management
2014-2015
Koo Foundation Sun Yat-Sen Cancer Center
2002
Heme oxygenase-1 (HO-1) is induced by a variety of stimuli and plays multifaceted role in cellular protection. We have shown that HO-1 overexpressed thyroid cancer associated with tumor aggressiveness. Therefore, we set out to assess the effects inhibitors on biology cells. Two different classes were used, including metalloporphyrin, zinc protoporphyrin-IX (ZnPP), an azole antifungal agent, ketoconazole. The viability colony formation cells decreased concentration- time-dependent fashion...
Aim . Our goal was to investigate associations among scaling-stimulated changes in salivary antioxidants, oral-health-related behaviors and attitudes, periodontal treatment outcomes. Materials Methods Thirty periodontitis patients with at least 6 pockets pocket depths of >5 mm more than 16 functional teeth were enrolled the study. Patients divided into three groups: an abandoned group (AB group), a nonprogress outcome (NP effective (ET group). Nonstimulated saliva collected before after...
Abnormal proliferation of vascular smooth muscle cells (VSMCs) is important in the pathogenesis disorders such as atherosclerosis and restenosis. Hinokitiol, a tropolone derivative found Chamacyparis taiwanensis, has been to exhibit anticancer activity variety cancers through inhibition cell proliferation. In present study, possible anti-proliferative effect hinokitiol was investigated on VSMCs. Our results showed that significantly attenuated PDGF-BB-stimulated VSMCs without cytotoxicity....
Objectives Perchlorate, nitrate, and thiocyanate are well-known inhibitors of the sodium-iodide symporter may disrupt thyroid function. This exploratory study investigated association among urinary perchlorate, concentrations parathyroid hormone (PTH) levels in general U.S. population. Methods We analyzed data on 4265 adults (aged 20 years older) from National Health Nutrition Examination Survey 2005 through 2006 to evaluate relationship concentration PTH presence hyperparathyroidism...
We previously demonstrated that the activation of α9-nicotinic acetylcholine receptor (α9-nAchR) signaling by smoking promotes breast cancer formation. To investigate downstream molecules involved in α9-nAChR-induced tumorigenesis, we used real-time polymerase chain reactions and Western blotting to assess expression protein phosphatase Mg2+/Mn2+ dependent 1F (PPM1F), a Ser/Thr phosphatase, human samples (n=167). Additionally, stable PPM1F-knockdown -overexpressing cell lines were...
Topoisomerase I (TOP1) participates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination catalytic subunit protein kinase (DNA-PKcs), a critical factor in DSB repair. This study aimed to investigate natural killer (NK) cell-mediated radiosensitization with TOP1 inhibition and mechanism by DNA-PKcs/RNF144A.In vitro synergism TOP1i or cocultured NK cells RT were evaluated human hepatocellular carcinoma (HCC) cell lines (Huh7/PLC5)...
Antrodia camphorata ( A. ) is a fungus generally used in Chinese folk medicine for treatment of viral hepatitis and cancer. Our previous study found has neuroprotective properties could reduce stroke injury cerebral ischemia animal models. In this study, we sought to investigate the molecular mechanisms effects middle artery occlusion (MCAO) rats. A selective (MCA) with whole blood clots was induce ischemic rats they were orally treated (0.25 0.75 g/kg/day) alone or combined aspirin (5...
Purpose: This study is to report the clinical and dosimetric parameters of six patients who were carriers type B chronic hepatitis developed grade 3 or 4 hepatic toxicity after adjuvant definitive concurrent chemoirradiation for gastric cancer. Materials Methods: From December 1993 through July 2001, 82 with adenocarcinoma underwent radiotherapy as treatment. Ten on serology test. Six 10 within months radiotherapy, formed basis this study. Five external-beam 45 Gy/1.8 Gy/25 fractions 18 MV...