A5081493238- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Cardiac, Anesthesia and Surgical Outcomes
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- Genital Health and Disease
- Nonmelanoma Skin Cancer Studies
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- Brain Metastases and Treatment
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Esophageal Cancer Research and Treatment
- CAR-T cell therapy research
Hospital Universitario Ramón y Cajal
2018-2025
Instituto Cajal
2018-2024
Instituto Ramón y Cajal de Investigación Sanitaria
2018-2024
Grupo ACS (Spain)
2024
Hospital Jerez Puerta del Sur
2022
Hospital Clínico San Carlos
2006-2020
Previous studies have suggested a negative impact of steroids on the efficacy immune checkpoint inhibitors (ICI), but how this effect is modulated by dosage and time administration yet to be clarified. We performed retrospective analysis 475 patients with advanced solid tumors treated ICI as monotherapy from 2015 2022. Data regarding immune-related adverse events (irAEs) clinical outcomes were collected. For each patient, daily steroid dose (in mg/kg prednisone) was registered until disease...
IntroductionPatients with cancer (PC) are at high risk of acquiring COVID-19 and can develop more serious complications. Deeper understanding vaccines immunogenicity in this population is crucial for adequately planning programs. The ONCOVac study aimed to comprehensively assess the mRNA-1273 vaccine terms humoral cellular response.MethodsWe conducted a prospective, single-center including patients solid tumours treated cyclin-dependent kinases 4 6 inhibitors (CDK4/6i), immunotherapy (IT) or...
Abstract In this study we have compiled the information from official databases about Iberian ibex, Capra pyrenaica , hunting yields, trophies and licenses in Spanish regions where species is present hunted. Such quotas showed an increasing trend between 2005–2021 and, on average, during period, ≈ 6400 animals were yearly harvested. Despite number decreased 2019 2020 (in last year, mainly due to lock down caused by COVID pandemia), annual quota raised, reaching over 12,000 ibexes 2021. The...
Combined BRAF/MEK inhibition with encorafenib (E) plus binimetinib (B) has demonstrated efficacy and tolerability in phase III clinical trials, is the standard of care for advanced/metastatic BRAFV600-mutant melanoma. However, real-life evidence limited, particularly patients pre-treated immune checkpoint inhibitors (ICI). BECARE GEM 2002 was a retrospective, non-interventional study aimed at investigating real-world effectiveness EB unresectable or metastatic melanoma conducted 21 sites...
ABSTRACT Background Increasing demand for elective surgery makes optimizing preoperative assessment a priority. Value-based healthcare aims to provide the highest value patients at lowest possible cost through various mechanisms including reorganizing care into integrated practice units (IPUs). However, few studies have analyzed effectiveness of implementing virtually led IPUs assessment. Methods We performed retrospective observational cohort study undergoing teaching hospital in Madrid,...
Background: The increasing demand for elective surgery makes optimizing preoperative assessment a priority. Value-based healthcare aims to provide the highest value patients at lowest possible cost through various mechanisms, including reorganizing care into integrated practice units (IPUs). However, few studies have analyzed effectiveness of implementing virtually led IPUs assessment. Methods: We performed retrospective observational cohort study undergoing teaching hospital in Madrid,...
Aims To evaluate if rivaroxaban, an oral factor Xa (FXa) inhibitor, could modify the expression in vitro of inflammatory and oxidative stress biomarkers abdominal aortic aneurysmal (AAA) sites showing intraluminal thrombus. Methods AAA with mural thrombus were obtained from six patients undergoing elective repair. In addition, control samples organ donors. incubated presence absence 50 nmol l –1 rivaroxaban. Results demonstrated higher content FXa than control. Interleukin‐6 levels released...
Abstract Background Immune checkpoint inhibitors (ICI) have changed the therapeutic landscape of many solid tumors. Modulation intestinal microbiota by antibiotics (Abx) has been suggested to impact on ICI outcomes. Methods Retrospective analysis 475 patients with advanced tumors treated from 2015 2022. For each patient, use Abx was recorded 1 month before initiation until disease progression or death. The objective response rates (ORR), control (DCR), progression-free survival (PFS), and...
71 Background: FOLFIRI in combination with Aflibercept (AFL) or Ramucirumab (RAM) prolongs overall survival compared alone patients advanced colorectal cancer (aCCR) as second-line therapy, however, there are no comparative studies between them. Methods: Utilizing the TriNetX Global Collaborative Network, a platform that operates globally based on anonymized and aggregated clinical data, sample of aCCR from 128 healthcare organizations (HCOs) who met initial criteria was selected. 5-year...
598 Background: Based on TOPAZ-1 trial, Durvalumab (DUR) plus gemcitabine and cisplatin significantly improved overall survival (OS) in advanced biliary tract cancer (aBTC) patients. Real-World data evidence can evaluate the benefit of this combination outside controlled studies comparing patients treated with standard chemotherapy or without DUR. Methods: Using TriNetX Global Collaborative Network, a platform that operates globally based anonymized aggregated clinical data, sample aBTC from...
Background: Despite EP (aged ≥70 years) represent the majority of patients with advanced NSCLC, efficacy and toxicity rates IT remain poorly described, as they are under-represented in clinical trials. Furthermore, age-related decline immune system might affect IT. Methods: We retrospectively reviewed NSCLC treated (antiPD-1, anti-PD-L1) monotherapy first, second subsequent-line settings, between 2014 2018 our hospital. Patient tumor features, irAEs, concomitant subsequent treatments were...
Few data are available about the immune response to mRNA SARS-CoV-2 vaccines in patients with breast cancer receiving cyclin-dependent kinase 4/6 inhibitors (CDK4/6i). We conducted a prospective, single-center study of treated CDK4/6i who received mRNA-1273 vaccination, as well comparative group healthcare workers. The primary endpoint was compare rate and magnitude humoral T-cell after full vaccination. A better neutralizing antibody anti-S IgG level observed vaccination subgroup women...
Androgenic deprivation therapies have been linked to the development of metabolic syndrome (MS) and cardiovascular diseases, which may lead a poorer survival in patients with metastatic Castration-Resistant Prostate Cancer (mCRPC). We aimed analyze whether some or neurological disorders, together other medical urological complications, an effect on outcomes, at baseline during treatment from treated androgen pathway inhibitors (API).A retrospective study consecutive series diagnosed mCRPC...
Not all hospitals have interventional radiology services. This fact implies that in centers where this resource is not available, the treatment of stroke acute phase must be adapted and individualized. The aim study to determine compare combined effect thrombolysis thrombectomy effectiveness safety tenecteplase versus alteplase ischemic patients who are candidates for endovascular therapy according clinical practice guidelines. paper details a retrospective multicenter cohort with admitted...
A 59 year-old woman was treated with adjuvant chemotherapy for triple negative breast cancer (TNBC) stage IB. She received pegfilgrastrim as secondary prophylaxis of neutropenia. After administration on day 11, she hospitalised because carotidynia and myocarditis that improved antibiotics steroids an infection suspected. Once recovered, another cycle administrated. At this time, the patient presented to our hospital fever, odynophagia chest pain, diagnosis coupled cardiogenic shock....
Squamous cell carcinoma (SCC) arising in a sacrococcygeal pilonidal sinus is rare, with cases of metastatic disease being even rarer. Among published cases, almost none have reported on systemic treatment.This has poorer prognosis than other forms cutaneous SCC; therefore, our objective to shed some light the treatment disease.We present series nine treated at single center, four whom received treatment. Additionally, previously are included an attempt draw stronger conclusions.Four patients...
Background: IT has improved outcomes in advanced NSCLC. However, this therapy can yield significant toxicity secondary to immune activation. Several retrospective studies have reported a direct relationship between efficacy and the development of irAEs, Response Rate (RR) survival. Methods: We reviewed our experience with anti-PD1/anti-PDL1 as single agent NSCLC patients treated February 2014 August 2018. Patient tumor features, concomitant subsequent treatments were collected. Stata 14.1...