A5083900608- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Gut microbiota and health
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Plant-based Medicinal Research
- Organ Transplantation Techniques and Outcomes
- Traditional Chinese Medicine Studies
- Lipid metabolism and disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cell death mechanisms and regulation
- ATP Synthase and ATPases Research
- Healthcare and Venom Research
- S100 Proteins and Annexins
- Endoplasmic Reticulum Stress and Disease
- Cardiac Arrest and Resuscitation
- Nitric Oxide and Endothelin Effects
Wenzhou Medical University
2015-2025
First Affiliated Hospital of Wenzhou Medical University
1997-2012
Wenzhou City People's Hospital
2010-2012
Integrated Chinese Medicine (China)
2012
Zhejiang Chinese Medical University
2011
Xiaomi (China)
2007
Ferroptosis was reported to be involved in cerebral ischemia-reperfusion injury (CIRI), on which the effects of berberine (BBR) remain unclear. Moreover, based critical role gut microbiota pleiotropic actions BBR, we hypothesized that BBR can suppress CIRI-induced ferroptosis by modulating microbiota. In this study, results showed obviously attenuated behavioral deficits CIRI mice, accompanied with improved survival rate and neuron damages, as phenocopied dirty cage experiment. The typical...
Lung ischemia/reperfusion injury (LIRI) is a clinical syndrome of acute lung that occurs after transplantation or remote organ ischemia. Ferroptosis and inflammation are involved in the pathogenesis LIRI according to results several studies on animal models. However, interactive mechanisms between ferroptosis contributing remain unclear.HE staining indicators oxidative stress were used evaluated injury. The reactive oxygen species (ROS) level was examined by DHE staining. quantitative...
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments clinic unsatisfactory. Metformin has been demonstrated be beneficial alleviate HIRI recent studies, however, underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota mice, which was confirmed by results fecal transplantation treatment but...
In Brief BACKGROUND: Acute lung injury is a recognized complication of lower limb ischemia–reperfusion that has been demonstrated experimentally and in the clinical setting aortic surgery. The application tourniquet can cause orthopedic We studied effect unilateral thigh tourniquet–induced on pulmonary function, role ischemic preconditioning attenuating dysfunction. METHODS: Thirty ASA I or II patients scheduled for extremity surgery were randomized into 2 groups: group with...
Pulmonary arterial hypertension (PAH) is a disease of the small pulmonary arteries characterized by increased vascular resistance. vasoconstriction has been proven to play pivotal role in PAH. We have previously hypothesized that Panax notoginseng saponins (PNS) might attenuate hypoxia-hypercapnia-induced vasoconstriction. The specific objective present study was investigate notoginsenoside R1, main ingredient PNS, this process and possible underlying mechanism. third order rings from...
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arteriolar resistance. vasoconstriction has been proved to play significant role in PAH. We previously reported that Panax notoginseng saponins (PNS) might attenuate hypoxia and hypercapnia-induced (HHPV).In the present study, our specific objective was investigate of ginsenoside Rg1, major component PNS, this process possible underlying mechanism. The second order rings isolated from Sprague-Dawley...
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments clinic unsatisfactory. Metformin has been demonstrated be beneficial alleviate HIRI recent studies, however, underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota mice, which was confirmed by results fecal transplantation treatment but...
Background: Receptor interacting serine/threonine kinase 1 (RIPK1) mediates apoptosis by regulating the classic proapoptotic effectors Bcl-2-associated X protein (Bax) and Bcl-2 homologous antagonist/killer (Bak). Although Bcl-2-related ovarian killer (Bok) is structurally similar to Bak Bax, it unclear whether in skeletal muscle ischemia reperfusion (IR) injury. We hypothesized that Bok-mediated apoptosis, inhibiting RIPK1 with necrostatin-1 would reduce IR Methods: Rats were randomized...
The tourniquet has been considered as a recognized cause of limb ischemia/reperfusion injury in orthopedic surgery resulting transient neutrophil, monocyte activation, and enhanced neutrophil transendothelial migration with potential remote tissue injury. This study investigated the effect unilateral application within safe time limit on pulmonary function roles lipid peroxidation systemic inflammatory response. Thirty patients undergoing lower extremity or without were equally divided into...
Ischemia-reperfusion injury in the myocardium after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) is an important pathologic basis of post-cardiac syndrome (PCAS), apoptosis one major mechanisms myocardial ischemia-reperfusion injury. To lessen CPR, it to reduce energy consumption increase supply myocardium. This study aimed observe changes cell expression Bcl-2 Bax protein on CPR rats, protective effects different doses exogenous phosphocreatine (creatine phosphate, CP) them.A...
Abstract Abnormal proliferation of vascular smooth muscle cells (VSMCs) induced by insulin resistance facilitates intimal hyperplasia type 2 diabetes mellitus (T2DM) and N6-methyladenosine (m 6 A) methylation modification mediates the VSMC proliferation. This study aimed to reveal m A regulatory mechanism. In this study, demethylase FTO was elevated in insulin-treated VSMCs T2DM mice with injury. Functionally, knockdown level further restrained migration insulin. Mechanistically, Smooth 22...
Tourniquet has been considered as a recognized cause of lower limb ischemia-reperfusion injury in the orthopedic field. This study investigates pulmonary function after tourniquet deflation and protective effect Shenmai injection (SMI), traditional Chinese medicine.Twenty-eight patients undergoing extremity surgery were randomized into control group (group C) SMI S), 14 each group. Blood gas circulating indicators (malondialdehyde, interleukin [IL]-6, IL-8) measured immediately before...
The effect of puerarin (Pur) on expressions Fas/FasL mRNAs in pulmonary ischemia and reperfusion injury (PIRI) rabbit was investigated. sole side lung model used. Rabbits were randomly divided into three groups, a sham operated group (sham, n = 10), PIR (IR, 30) + Pur (Pur, 30). Changes several parameters including apoptotic index (AI), wet to dry ratio tissue weight (W/D) quantitative assessment histologic (IQA) measured after 60, 180 300 minutes reperfusion. Meanwhile, the location...
The aim of the present study was to investigate effect notoginsenoside Rb1 (Rb1) on ERK and p38 MAPK pathways in primary cultured pulmonary arterial smooth muscle cells (PASMCs) exposed hypoxia hypercapnia, order elucidate mechanism underlying hypercapnia-induced vasoconstriction (HHPV). PASMCs were isolated from Sprague-Dawley rats. divided into five groups: Normal (N), hypercapnia (H), RbL, RbM RbH groups. N group under 5% CO2 21% O2. H, groups 6% 1% Prior exposure, treated with 8, 40 100...
The aim of this study is to investigate the effect heme oxygenase-1 (HO-1)/carbon monoxide (CO) system in pulmonary ischemia-reperfusion injury (PIRI) rabbits. rabbits were randomly assigned three groups (n=10, each): control group (C), PIR (I-R), PIR+Hemin (H) and PIR+zinc protoporphyrin IX (ZnPP) (Z). There changes several parameters which included plasma carboxyhemoglobin (COHb), wet dry ratio lung tissue weight (W/D), injured alveoli rate (IAR) HO-1 enzymatic activity....