A5101625605- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Legionella and Acanthamoeba research
- Retinal Diseases and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Craniofacial Disorders and Treatments
- Mitochondrial Function and Pathology
- Intraocular Surgery and Lenses
- Ophthalmology and Eye Disorders
- Ophthalmology and Visual Impairment Studies
- Retinal and Optic Conditions
Combined Ophthalmic Research Rotterdam
2019-2025
Rotterdam Eye Hospital
2006-2025
To evaluate the incidence of Acanthamoeba keratitis in Netherlands between 2009 and 2015 to analyse predicting factors for treatment outcome.Patient characteristics, diagnostic methods, delay, therapy prior after diagnosis, visual outcome were obtained from medical files all patients diagnosed with 2015. A logistic regression analysis on failure, defined as a best corrected acuity less than 20/40 Snellen decimals (i.e. >0.3 logMAR or an approximate loss three lines acuity) and/or need...
Four patients with chronic progressive external ophthalmoplegia (c.p.e.o.), retinal, neurological, endocrine and auditory anomalies, three of whom showed signs cardio-myopathy, are described. On biochemical examination disturbed pyruvate lactate metabolism were found there indications loss respiratory control loosely coupling phosphorylation (from oxidation). In the muscle biopsy specimens from all four aggregates abnormal mitochondria seen, compatible diagnosis a mitochondrial myopathy. A...
During the COVID-19 pandemic, there was a significant decline in number of patients with both non-urgent and urgent ophthalmologic conditions presenting to emergency departments, leading concerns about whereabouts need care. We hypothesized that an actual decrease microbial keratitis (MK) cases, due reduced contact lens (CL) wear improved hand hygiene, including alcohol-based disinfection. Besides, we questioned if non-pharmaceutical interventions would have sustained effect after pandemic....
Abstract Machine learning can be used to explore the complex multifactorial patterns underlying postsurgical graft detachment after endothelial corneal transplantation surgery and evaluate marginal effect of various practice pattern modulations. We included all posterior lamellar keratoplasty procedures recorded in Dutch Cornea Transplant Registry from 2015 through 2018 collected center-specific using a questionnaire. All available data regarding donor, recipient, surgery, pattern, were...
Comparison of conventional Penetrating Keratoplasty (PKP), posterior mushroom PKP and Descemet's Stripping Automated Endothelial (DSAEK) regarding overall graft survival primary corneal transplants for Fuchs´ endothelial dystrophy (FED), best spectacle-corrected visual acuity (BSCVA) astigmatism.Single centre study using prospectively collected data from the national database follow-up transplants. Main outcome parameters: 10 years survival, astigmatism at 24 months, pre- post-operative...
To describe the learning curve for Descemet's membrane endothelial keratoplasty (DMEK) in Rotterdam Eye Hospital and to evaluate safety visual outcome.This was a single-centre prospective study of 40 consecutive patients with Fuchs' dystrophy who underwent DMEK procedure Hospital. The performance two corneal surgeons, each conducting their first series 20 procedures, examined cumulative summation test (LC-CUSUM). surgical considered unsuccessful when >30% graft not attached at any time...
To analyse the effect of topical corticosteroids before start anti-amoebic therapy (AAT) in Acanthamoeba keratitis (AK) on final visual outcome and to identify factors that affect outcome.A retrospective case control study medical records patients diagnosed with AK at Rotterdam Eye Hospital between 2003 2017 was performed. Patient demographic clinical data were collected. The outcomes treated AAT compared those not corticosteroids. Univariable multivariable analyses conducted.A total 109 AK,...
Acanthamoeba keratitis is almost universally associated with contact lens (CL) use. Until today, however, CL solution manufacturing protocols lack testing of anti-amoebic activity. This study investigates the effectiveness solutions available on Dutch market against trophozoites and cysts castellanii polyphaga. Sixteen were tested: 13 multiple purpose (MPS), 2 hydrogen peroxidase (HPS) 1 povidone-iodine-based (PIS). The Spearman-Karber (SK) log reduction method an XTT colorimetric assay used...
Purpose . To investigate the long-term anatomical and functional outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK). Methods Prospective follow-up 114 eyes (95 subjects) after DSAEK for dysfunction. Measurements included best spectacle-corrected visual acuity (BSCVA), straylight, cell density (ECD), graft thickness. Results The mean time was 5.1 ± 1.5 years. Four grafts ultimately failed (after 5 to 7 years). From baseline up 1 year DSAEK, BSCVA improved by 0.30...
Abstract Purpose To evaluate the cost‐effectiveness of ultrathin Descemet stripping automated endothelial keratoplasty ( UT ‐ DSAEK ) versus standard . Methods A analysis using data from a multicentre randomized clinical trial was performed. The time horizon 12 months postoperatively. Sixty‐four eyes 64 patients with Fuchs’ dystrophy were included and to n = 33) or 31). Relevant resources healthcare societal perspectives in cost analysis. Quality‐adjusted life years QALY s) determined Health...
To measure the penetration of fluorescein into anterior ocular compartments after exposure cornea to a mist aerosol droplets.This was an open-label proof-of-principle trial. Eighteen healthy volunteers were asked participate. A conventional (50 μL) drop solution (20 mg/mL) administered right eye; (10 same applied left eye. Autofluorescence (photons/s) measured in cornea, chamber (AC), and lens before administration at 1, 2, 5, 10, 20, 50, 100 min thereafter. The area under curve (AUC)...
To accurately measure ultrathin Descemet stripping automated endothelial keratoplasty (DSAEK) donor lamella thickness during the first postoperative year and to correlate this with pre-operative other measurements.Donor in 41 eyes undergoing DSAEK for Fuchs dystrophy (FED) was measured using Tomey Casia OCT directly after graft preparation at 1 week 1, 3, 6 12 months postoperatively. Visual acuity cell density were as secondary parameters.Individual profiles shown be fairly regular within...