A5103188992- TGF-β signaling in diseases
- Cancer-related gene regulation
- Alzheimer's disease research and treatments
- Hippo pathway signaling and YAP/TAZ
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Bioactive Compounds
University of California, San Francisco
2013-2017
San Francisco VA Medical Center
2013
Blocking dual leucine zipper kinase slows disease progression in animal models of ALS and Alzheimer’s disease.
Several critical events dictate the successful establishment of nascent vasculature in yolk sac and developing embryos. These include aggregation angioblasts to form primitive vascular plexus, followed by proliferation, differentiation, migration, coalescence endothelial cells. Although transforming growth factor–β (TGF-β) is known regulate various aspects development, signaling mechanism TGF-β remains unclear. Here we show that homeodomain interacting protein kinases, HIPK1 HIPK2, are...