A5100675682- Spinal Cord Injury Research
- Sport Psychology and Performance
- Gun Ownership and Violence Research
- Resilience and Mental Health
- Monoclonal and Polyclonal Antibodies Research
- Suicide and Self-Harm Studies
- Stroke Rehabilitation and Recovery
- Cancer Treatment and Pharmacology
- Motor Control and Adaptation
- COVID-19 and healthcare impacts
- Urinary and Genital Oncology Studies
- Behavioral and Psychological Studies
- Child Abuse and Trauma
- Colorectal Cancer Treatments and Studies
- Drug Transport and Resistance Mechanisms
- Cancer Genomics and Diagnostics
- Action Observation and Synchronization
- Venous Thromboembolism Diagnosis and Management
- Neural and Behavioral Psychology Studies
- Homelessness and Social Issues
- Migration, Health and Trauma
- Healthcare cost, quality, practices
- Bladder and Urothelial Cancer Treatments
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
Research for Equity And Community Health Trust
2024
Christiana Care Health System
2018-2024
Institute for Community Health
2024
Kaiser Foundation Hospital
2023
Colorado Permanente Medical Group
2023
Kaiser Foundation Hospital
2023
Hospital for Sick Children
2023
Advisory Board Company (United States)
2022
Philadelphia University
2013-2019
Northwestern University
2004-2019
Human P-glycoprotein (Pgp), a plasma membrane protein that confers multidrug resistance, functions as an ATP-dependent drug efflux pump. Pgp contains two ATP binding/utilization sites and exhibits ATPase activity is stimulated in the presence of substrates modulating agents. The mechanism coupling hydrolysis to transport not known. To understand role binding, it necessary develop methods for purifying reconstituting retains properties including stimulation by known extent similar native...
Abstract Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition associated with germline TP53 pathogenic variants. Here, we perform whole-genome sequence (WGS) analysis of tumors from 22 patients We observe somatic mutations affecting Wnt, PI3K/AKT signaling, epigenetic modifiers and homologous recombination genes as well mutational signatures prior chemotherapy. identify near-ubiquitous early loss heterozygosity , gain the mutant allele. This occurs earlier in these compared to...
Background/objectiveLength of stay (LOS) for rehabilitation treatment after spinal cord injury (SCI) has been documented extensively. However, there is almost no published research on the nature, extent, or intensity various treatments patients receive during their stay. This study aims at providing such information a large sample treated by specialty inpatient programs.MethodsSix hundred with traumatic SCI admitted to six centers were enrolled. Time spent therapeutic activities was each...
Abstract Ten patients with refractory B cell lymphomas were treated weekly intravenous infusions of escalating doses murine monoclonal antibody (MoAb) LYM‐1 over four weeks. is a recently developed IgG2a MoAb that recognizes polymorphic HLA‐Dr antigen on surfaces normal and malignant cells but does not bind to any other tissues. has several advantages for serotherapy, since the it shed from surface modulate in response therapy. Furthermore, vitro studies have indicated significant...
This study aims to determine COVID-19 patient demographics and comorbidities associated with their hospital length of stay (LOS).Design: Single-site, retrospective study. Setting: A suburban 700-bed community in Newark, Delaware, USA. Patients: Patients admitted the from March 11, 2020, August a positive status. We followed time-to-event analysis approach used Kaplan-Meir curves log-rank tests for bivariate analyses, an accelerated failure time model multivariable LOS.Six hundred...
Hepatopulmonary syndrome is a well described complication of chronic liver disease. Though uncommon, it carries high morbidity and mortality. The pathogenesis the has not been clearly defined. Portal hypertension seems to play crucial role in syndrome, probably by enhancing nitric oxide production. As yet, no pharmacological therapy proven effective. Many reports successful reversal after transplantation have published. We report patient with hepatopulmonary who showed significant durable (4...
The objective of the present study was to examine genetically determined differences in natriuretic peptide receptor-A (NPRA) gene (Npr1) copies affecting expression cardiac hypertrophic markers, proinflammatory mediators, and matrix metalloproteinases (MMPs) a gene-dose-dependent manner. We whether stimulation Npr1 by all-trans retinoic acid (RA) histone deacetylase (HDAC) inhibitor sodium butyric (SB) suppress disease markers. In study, we utilized gene-disrupted heterozygous (Npr1(+/-),...
Total body photography may aid in melanoma screening but is not widely applied due to time and cost. We hypothesized that a near-simultaneous automated skin photo-acquisition system would be acceptable patients could rapidly obtain total images enable visualization of pigmented lesions.From February May 2009, study 20 volunteers was performed at the University Virginia test prototype 16-camera imaging booth built by research team guide development special purpose software. For each...
(2003). A Classification System for Metaphors about Teaching. Journal of Physical Education, Recreation & Dance: Vol. 74, No. 2, pp. 24-31.
Background: Subcutaneous administration of low molecular weight heparin (eg, enoxaparin) has been shown tobe safe and effective in the prevention acute venous thromboembolic (TE) disease following spinal cord injury (SCI) rehabilitation setting.However, ernerging evidence suggests that different dosing strategies may be equivalent.Objective: Todetermine whether subcutaneous enoxaparin, 40 mg once daily, when compared with 30mg twice is equally inthe TE patients SC I.Design: Retrospective...
3040 Background: Baseline (BL) pVEGFA level has been investigated as a predictive biomarker for the clinical efficacy of anti-VEGF therapy with Bv in 13 trials (7 indications).Three studies, AVADO (breast cancer [BC]), AVAGAST (gastric cancer), and AVITA (pancreatic [PC]), reported that high BL was associated prolonged PFS or OS, but contrasting data were obtained other trials. Therefore, potential factor activity specific oncological indications individual pts remains poorly understood....
Locomotor training has been used to improve walking function in people with incomplete spinal cord injury (iSCI), but functional gains are relatively small for some patients, which may be due the lack of weight shifting training.To determine whether applying a pelvis assistance force coronal plane during would and stepping iSCI.Repeated measures study.Rehabilitation hospital.Seventeen iSCI.A controlled was bilaterally applied medial-lateral direction facilitate shifting, gradually increased...
A functional binding site for a liver-enriched transcription factor, hepatocyte nuclear factor-4 (HNF-4), has previously been identified around −100 in the CYP2C2 promoter and proposed to be common regulatory motif hepatic expression of many CYP2 genes. The transcriptional activity proximal promoters three closely related cytochrome P450 genes (CYP2C1, CYP2C2, CYP2C3) have compared HepG2 cells correlated with relative affinities HNF-4 motifs proteins liver, kidney, extracts that react...
In this Account, recent advances in the total synthesis of complex molecular architectures originating from author’s laboratory are highlighted and discussed. Through thoughtful planning, intelligence gathering, often serendipitous discoveries, a diverse collection natural products spanning several structural classes have been successfully synthesized. The valuable information garnered these synthetic campaigns showcases unparalleled undisputed value historical discipline its cemented role...
(2001). Trends in Augmented Feedback Research and Tips for the Practitioner. Journal of Physical Education, Recreation & Dance: Vol. 72, No. 1, pp. 32-36.