A5073538132- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- COVID-19 Impact on Reproduction
- Immune cells in cancer
- Ginseng Biological Effects and Applications
- Genetic factors in colorectal cancer
- RNA and protein synthesis mechanisms
- Phagocytosis and Immune Regulation
- Bacteriophages and microbial interactions
- Neonatal Respiratory Health Research
- Humic Substances and Bio-Organic Studies
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Galectins and Cancer Biology
- Escherichia coli research studies
- Microscopic Colitis
- Respiratory viral infections research
- Gut microbiota and health
- Enterobacteriaceae and Cronobacter Research
- FOXO transcription factor regulation
Massachusetts Institute of Technology
2018-2023
Boston University
2021-2022
University of Minnesota
2012-2013
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model infection. We evaluated clinical and virological dynamics using two intranasal doses (104 106 PFUs), with detailed spatiotemporal pathologic analysis dose cohort. Despite generally mild-to-moderate pneumonia, decline resulting...
The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by lack appropriate experimental platforms recapitulating immune responses in a controlled lung environment. Here, we report mouse model (i.e., HNFL mice) co-engrafted with fetal xenografts (fLX) and myeloid-enhanced system to identify cellular molecular correlates protection during infection. Unlike mice solely engrafted fLX, are protected against...
Abstract C57BL/6 (B6) mice from Taconic Sciences (Tac) and the Jackson Laboratory (Jax) were infected with H . pylori PMSS1 (Hp) for 16 week; there was no significant difference in gastric histologic activity index between Hp Tac Jax B6. However, degree of mucous metaplasia Th1-associated IgG2c levels response to infection increased over mice, whereas colonization higher by 8-fold B6 compared Additionally, mRNA expression Il-1β , Il-17A RegIIIγ significantly lower mice. There differences...
Animal models recapitulating distinctive features of severe COVID-19 are critical to enhance our understanding SARS-CoV-2 pathogenesis. Transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model infection. The precise mechanisms lethality in this mouse remain unclear. Here, we evaluated spatiotemporal dynamics infection for up 14 days post-infection. Despite and moderate pneumonia, rapid clinical decline or...
Although many Escherichia coli strains are considered commensals in mammals, encoding the cyclomodulin genotoxins associated with clinical and subclinical disease urogenital gastrointestinal tracts, meningitis, inflammatory disorders. These include polyketide synthase (pks) pathogenicity island, cytolethal distending toxin (cdt), hemolysin-associated cytotoxic necrotizing factor (cnf). E. not excluded from rodents housed under SPF conditions academic or vendor facilities. This study isolated...
Blue iguanas ( Cyclura lewisi ) are endangered reptiles found only on Grand Cayman. Previously, DNA for a novel Helicobacter species GCBI1 was detected in sick and dead iguanas. In the current study, fecal cloacal swab samples were obtained from 25 Through molecular microbiological techniques, cultured feces characterized, whom we propose name cyclurae . This helicobacter had prevalence of 56% by PCR 20% culture analyzed. The type strain MIT 16-1353 catalase, oxidase, gamma-glutamyl...
ABSTRACT Helicobacter pylori ( H. ) causes a cascade from gastritis to gastric neoplasia. During the chronic stages, oncogenic transcription factor forkhead box protein M1 FOXM1 becomes increasingly expressed. Given certain strains of commensal Cutibacterium acnes C. produce thiopeptides that directly inhibit FOXM1, we hypothesized coinfection with thiopeptide-positive would decrease Foxm1 expression and alter -induced pathogenesis. was isolated 31% biopsies Nicaraguan patients, were...
SUMMARY The majority of SARS-CoV-2 infections among healthy individuals result in asymptomatic to mild disease. However, the immunological mechanisms defining effective lung tissue protection from infection remain elusive. Unlike mice solely engrafted with human fetal xenograft (fLX), co-engrafted fLX and a myeloid-enhanced immune system (HNFL mice) are protected against infection, severe inflammation, histopathology. Effective control viral HNFL associated significant macrophage...
Johne's disease can be an economically devastating on dairy farms. Current risk assessment (RA)-based control programs use best management practices to prevent the transmission of causative pathogen, Mycobacterium avium subsp paratuberculosis (MAP), between animals. Most effort is focused fecal-oral route infectious dams and calves. Because MAP has been isolated from water troughs, objective this pilot study was determine whether detected in saliva (a previously overlooked transmission)...
The human immunological mechanisms defining the clinical outcome of viral respiratory infections remain elusive. This knowledge gap is mostly driven by lack appropriate experimental platforms recapitulating myeloid immune responses in a lung environment. Here, we report novel mouse model (i.e. HNFL mice) co-engrafted with fetal xenografts (fLX) and myeloid-enhanced system. Using combination multi-omics approach SARS-CoV-2 as prototypical virus, demonstrate that represent promising platform...