A5016960537- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- T-cell and Retrovirus Studies
- SARS-CoV-2 detection and testing
- Vector-borne infectious diseases
- Immune Cell Function and Interaction
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial infections and disease research
- interferon and immune responses
- Malaria Research and Control
- Toxoplasma gondii Research Studies
- Bat Biology and Ecology Studies
Louisiana State University
2014-2025
Louisiana State University Agricultural Center
2023-2024
University of Kentucky
2011-2021
University of California, Davis
1998-2018
University of Idaho
2013-2015
MEP Equine Solutions (United States)
2014
Washington State University
1998-2013
Rogers (United States)
2013
Virginia–Maryland College of Veterinary Medicine
2011
Virginia Tech
2011
The arterivirus family (order Nidovirales ) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus equine arteritis (EAV). Their replicative enzymes are translated from their genomic RNA, while seven structural proteins encoded by a set small, partially overlapping genes in the 3′-proximal region. latter expressed via synthesis subgenomic mRNAs that, general, functionally monocistronic (except for bicistronic mRNA encoding E GP2 proteins)....
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Disease 2019 (COVID-19) and responsible for current pandemic. Recent SARS-CoV-2 susceptibility studies in cats show that virus can replicate these companion animals transmit to other cats. Here, we present an in-depth study infection, disease transmission domestic Cats were challenged with via intranasal oral routes. One day post challenge (DPC), two sentinel introduced. Animals monitored clinical signs,...
The family Arteriviridae comprises enveloped RNA viruses with a linear, positive-sense genome of approximately 12.7 to 15.7 kb. spherical, pleomorphic virions have median diameter 50-74 nm and include eight eleven viral proteins. Arteriviruses infect non-human mammals in vector-independent manner. Infections are often persistent can either be asymptomatic or produce overt disease. Some arteriviruses important veterinary pathogens while others particular species wild rodents African primates....
SARS-CoV-2 was first reported circulating in human populations December 2019 and has since become a global pandemic. Recent history involving SARS-like coronavirus outbreaks have demonstrated the significant role of intermediate hosts viral maintenance transmission. Evidence natural infection experimental infections wide variety animal species been demonstrated,
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represent a lethal model infection. We evaluated clinical and virological dynamics using two intranasal doses (104 106 PFUs), with detailed spatiotemporal pathologic analysis dose cohort. Despite generally mild-to-moderate pneumonia, decline resulting...
The emergence of SARS-CoV-2 has resulted in an ongoing global pandemic with significant morbidity, mortality, and economic consequences. susceptibility different animal species to is concern due the potential for interspecies transmission, requirement pre-clinical models develop effective countermeasures. In current study, we determined ability (i) replicate porcine cell lines, (ii) establish infection domestic pigs via experimental oral/intranasal/intratracheal inoculation, (iii) transmit...
Rapid evolution of highly pathogenic avian influenza viruses (HPAIVs) is driven by antigenic drift but also reassortment, which might result in robust replication and transmission to mammals. Recently, spillover clade 2.3.4.4b HPAIV mammals including humans, their between mammal species has been reported. This study aimed evaluate the pathogenicity transmissibility a mink-derived H5N1 isolate from Spain pigs. Experimental infection caused interstitial pneumonia with necrotizing bronchiolitis...
Summary In March 2024, highly pathogenic avian influenza virus (HPAIV) clade 2.3.4.4b H5N1 infections in dairy cows were first reported from Texas, USA. Rapid dissemination to more than 190 farms 13 states followed. Here, we provide results of two independent experimental infection studies evaluating (i) oronasal susceptibility and transmission calves a US bovine isolate genotype B3.13 (H5N1 B3.13) (ii) lactating following direct mammary gland inoculation either or current EU wild bird euDG...
The recently emerged novel coronavirus, SARS-CoV-2, is phylogenetically related to bat coronaviruses (CoVs), specifically SARS-related CoVs from the Eurasian family Rhinolophidae. As this human pandemic virus has spread across world, potential impacts of SARS-CoV-2 on native North American populations are unknown, as ability bats serve reservoirs or intermediate hosts able transmit humans other animal species. To help determine populations, we experimentally challenged big brown (Eptesicus...
SARS-CoV-2 is the causative agent of COVID-19 and responsible for current global pandemic. We others have previously demonstrated that cats are susceptible to infection can efficiently transmit virus naïve cats. Here, we address whether exposed be re-infected with SARS-CoV-2. In two independent studies, SARS-CoV-2-infected were re-challenged at 21 days post primary challenge (DPC) necropsies performed 4, 7 14 post-secondary (DP2C). Sentinels co-mingled 1 DP2C. Clinical signs recorded, nasal,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for a global pandemic that has had significant impacts on human health and economies worldwide. SARS-CoV-2 highly transmissible the cause of disease 2019 in humans. A wide range animal species have also been shown to be susceptible by experimental and/or natural infections. Sheep are commonly farmed domestic ruminant not thoroughly investigated their susceptibility SARS-CoV-2. Therefore, we performed vitro vivo...
Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well many mammalian species birds, affecting them at young age. This group viruses has double-stranded, segmented RNA genome with high genetic diversity linked to point mutations, recombination, and, importantly, reassortment. While initial molecular investigations undertaken the 1900s suggested host range restriction among based on fact that different gene segments were distributed animal...
Since the first emergence of highly pathogenic avian influenza (HPAI) H5N1 viruses in dairy cattle, virus has continued to spread, reaching at least 17 states and 970 herds United States. Subsequently, spillovers from cattle humans have been reported. Pigs are an important reservoir ecology because they serve as a mixing vessel which novel reassortant with pandemic potential can be generated. Here, we show that oro-respiratory infection pigs resulted productive replication bovine-derived...
The COVID-19 pandemic, caused by SARS-CoV-2, is still significantly impacting health care systems around the globe. Refined animal models are needed to study SARS-CoV-2 pathogenicity as well efficacy of vaccines and therapeutics.
The current global COVID-19 pandemic once again highlighted the urgent need for a simple, cost-effective, and sensitive diagnostic platform that can be rapidly developed distribution easy access in resource-limited areas. Here, we present simple low-cost plasmonic photothermal (PPT)-reverse transcription-colorimetric polymerase chain reaction (RTcPCR) molecular diagnosis of dengue virus (DENV) infection. assay completed within 54 min with an estimated detection limit 1.6 copies/μL viral...