A5080507441- Visual perception and processing mechanisms
- Ocular Surface and Contact Lens
- Impact of Light on Environment and Health
- Ocular and Laser Science Research
- Glaucoma and retinal disorders
- Digital Imaging in Medicine
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Architecture and Art History Studies
- Developmental and Educational Neuropsychology
- Historical Art and Architecture Studies
- Color Science and Applications
- Retinal Development and Disorders
- Ocular Disorders and Treatments
- RNA modifications and cancer
- Renal Transplantation Outcomes and Treatments
- Educational Technology in Learning
- Cancer-related gene regulation
- Antibiotics Pharmacokinetics and Efficacy
- Retinal Diseases and Treatments
- Epigenetics and DNA Methylation
- Color perception and design
- Aging, Health, and Disability
- Advanced Optical Sensing Technologies
Universidad de Valladolid
2004-2024
Hospital Clínico Universitario Virgen de la Victoria
2024
Universidad de Málaga
2002-2023
University of Birmingham
2020
Hospital Universitario Ramón y Cajal
2008
Purpose. To investigate the influence of water content in non-ionic hydrogel contact lenses (HCL) on mRNA levels human conjunctival mucin genes (MUCs). Methods. Sixteen healthy subjects with no history wear were selected and randomized into two equal groups. Group 1 wore low (38%, Soflens 38) HCLs. 2 high (66%, 66) Conjunctival impression cytology was applied to superior bulbar conjunctiva both eyes before, 6 months, year after HCL fitting, 15 days discontinuation wearing. Total RNA...
Plasma levels of 8-methoxypsoralen (8-MOP) were determined by high-pressure liquid chromatography in 19 patients with psoriasis who receiving bath-PUVA treatment, at different time points after the psoralen bath. The 8-MOP varied between < 5 ng/ml (lower limit detection) and 34 ng/ml, we found a relationship plasma severity disease.
Citation information : Matesanz BM, Issolio L, Arranz I, de la Rosa C, Menéndez JA, Mar S & Aparicio JA. Temporal retinal sensitivity in mesopic adaptation. Ophthalmic Physiol Opt 2011, 31 , 615–624. doi: 10.1111/j.1475‐1313.2011.00859.x Abstract Purpose: Night driving is a complex visual task with important ramifications for driver and pedestrian safety. It usually performed under or scotopic conditions frequently, the presence of transient glare sources that can adapt parts central...
Objective This study aims to analyze the effect of correlated color temperature from LED glare sources on driving performance. The evaluation includes assessing disability visual reaction time and rating discomfort using a standardized scale. Background technology is widely incorporated into various lighting systems; however, impact oncoming car headlamps performance at night-time crucial for road safety. Method Twenty-three healthy young subjects participated in laboratory-based experiment...
To determine the influence of surround luminance on letter contrast sensitivity function.The binocular sensitivities 31 young and ocularly healthy individuals were measured with letters sizes calculated to obtain targeted fundamental frequencies 3, 10, 20, 30 c deg(-1), respectively; luminances from 1 1000 cd m(-2), always a test chart background 200 m(-2).The increased up 100 m(-2) decreased when m(-2). These increments are larger for higher spatial frequencies, while decrements similar all...
Digoxin pharmacokinetics were studied in a pediatric population with an age range of 6 days to 1 year using the pharmacokinetic approach. data analyzed by mixed-effects modeling according one-compartment steady-state model NONMEM software. The final selected for prediction digoxin clearance patients was as follows: [equation: see text] Individual empirical Bayesian estimates generated on basis and used correlate optimum dose patient following equation: This equation its derived nomogram may...
We explored the complexity of light adaptation process, assessing recovery (Ar) at different eccentricities and levels. Luminance thresholds were obtained with transient background fields mesopic photopic levels for temporal retinal (0°-15°) test/background stimulus size 0.5°/1° using a staircase procedure in two-channel Maxwellian view optical system. Ar was comparison steady data [Vis. Res.125, 12 (2016)VISRAM0042-698910.1016/j.visres.2016.04.008]. Light level proportionally affects only...
The increasing replacement of traditional lamps by LED technology opens the door to research into visual performance under their multiple possible spectral power distributions. correlated color temperature and S/P-ratio are considered parameters characterizing spectrum a light source. lack firm conclusions motivates analysis in this work influence spectrum, which is defined S/P-ratio, on representative night-driving task, reaction time. A two-channel four primaries photostimulator was used...
This work discusses the relative significance of optical and neural mechanisms in letter contrast sensitivity under different conditions environmental lighting. A study was carried out on 26 eyes with normal ocular health. Sixteen lighting were obtained by combining test luminances (from 10 cd/m 2 to 600 ) surround 1 ). The results reveal a significant influence factors (pupil size variations glare effects) when luminance changes, dominance effects changes. Furthermore, illumination are...
<b>Aims:</b> To evaluate ibuprofen population pharmacokinetics in a large series of data collected children with cystic fibrosis (CF) treated high doses (59 patients; 2–18 years), and to identify the main causes responsible for considerable interindividual variability serum levels. <b>Methods:</b> Blood samples were during routine clinical care; concentrations determined by HPLC. Fitting concentration/time one compartment kinetic model was performed non-linear mixed effect regression method....
Abstract Background Several studies have suggested secreted frizzled-related protein 2 ( SFRP2 ) gene as a potential clinical biomarker in colorectal cancer (CRC). However, its diagnostic role remains unclear. In this study, we aimed to investigate the significance of methylation levels large cohort biological specimens (including blood, adipose and colonic tissues) from patients with CRC, thereby potentially identifying new utility. Methods We examined expression (by qPCR) status 450 K DNA...
Extracorporeal photochemotherapy (ECP), also known as photopheresis, is a generally well-tolerated therapeutic, immunomodulatory approach successfully used in cutaneous T-cell lymphoma and other diseases produced by T-lymphocytes such graft vs host disease.On 2 separate occasions, 54-year-old white man with Sézary syndrome developed phototoxic reactions chorioretinitis after being treated ECP. A pharmacokinetic study showed therapeutic blood levels of 8-methoxypsoralen long 18 weeks therapy...
The purpose of this work is to analyze the interaction between spectral transmittance old-aged subjects, before and after cataract surgery blue light-filtering intraocular lens implantation, power distribution common street lamps, under conditions typical nighttime driving. We analyzed contrast threshold visual reaction time in off-axis vision at different mesopic illumination provided by high-pressure sodium metal halide lamps. Three groups subjects with transmittances participated: young...
The influence of lighting different spectral power distribution on letter contrast sensitivity has been studied. distributions were obtained by filtering or dimming tungsten halogen lamps. Measurements made 20 young and healthy individuals (25 eyes) whose monocular sensitivities measured with a natural pupil. Sixteen combinations test surround luminance high low correlated colour temperatures studied in such way that the luminance, temperature both visual fields could be independently Both...