Recent work has recognized a gradient-like organization in cortical function, spanning from primary sensory to transmodal cortices. It been suggested that this axis is aligned with regional differences neurotransmitter expression. Given the abundance of dopamine D1-receptors (D1DR), and its importance for modulation neural gain, we tested hypothesis D1DR functional architecture, inter-regional relationships co-expression modulate cross talk. Using world's largest D1DR-PET MRI database ( N =...

Age-related alterations in D1-like dopamine receptor (D1DR) have distinct implications for human cognition and behavior during development aging, but the timing of these periods remains undefined. Enabled by a large sample vivo assessments (n = 180, age 20 to 80 years age, 50% female), we discover that age-related D1DR differences pivot at approximately 40 several brain regions. Focusing on most age-sensitive dopamine-rich region, observe opposing pre- post-forties interrelations among...

Concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is crucial in promoting healthy aging. Here, we present the DopamiNe, Age, connectoMe, Cognition (DyNAMiC) project, a multimodal, prospective 5-year longitudinal study spanning adult human lifespan. DyNAMiC examines changes brain's structural functional connectome relation to dopamine D1 receptor availability (D1DR), their associations decline. Critically, due...

Abstract Age-related alterations in cortico-striatal function have been highlighted as an important determinant of declines flexible, higher-order, cognition older age. However, the mechanisms underlying such remain poorly understood. Computational accounts propose age-related dopaminergic decreases to impoverish neural gain control, possibly contributing reduced specificity circuits, that are modulated by dopamine, Using multi-modal neuroimaging data (fMRI, PET) from a large lifespan cohort...

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e., gradients) persist across adult human lifespan, relate to memory molecular...

A key question in human neuroscience is to understand how individual differences brain function are related cognitive differences. However, the optimal condition of study between-person cognition remains unclear. Additionally, there a lack objective biomarkers accurately predict function, with age emerging as potential candidate. Recent research suggests that offers minimal additional information on decline beyond what chronological provides, prompting shift toward approaches focused...

A key question in human neuroscience is to understand how individual differences brain function are related cognitive differences. However, the optimal condition of study between-person cognition remains unclear. Additionally, there a lack objective biomarkers accurately predict function, with age emerging as potential candidate. Recent research suggests that offers minimal additional information on decline beyond what chronological provides, prompting shift toward approaches focused...

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e. gradients) persist across adult human lifespan, relate to memory molecular markers...

fMRI studies have identified distinct resting-state functional connectivity (RSFC) networks associated with the anterior and posterior hippocampus. However, relevance of these two is still largely unknown. Hippocampal lesion task-related point to a role for hippocampus in nonspatial episodic memory spatial memory. We used Relevance Vector Regression (RVR), machine-learning method that enables predictions continuous outcome measures from multivariate patterns brain imaging data, test...

The hippocampus (HC) interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole-brain structural covariance. It also unclear whether the anterior posterior HC show similar or distinct patterns of covariance what extent these are related functions organized along longitudinal axis. Using multivariate approach partial least squares, we assessed addition regional volume, young,...

Abstract The hippocampal longitudinal axis has been linked to dissociated functional networks relevant episodic memory. However, the organization of axis-dependent and their relation memory in aging remains less explored. Moreover, age-related deterioration dopamine (DA) system, affecting network properties, might constitute a source reduced specificity aging. Here, we characterized large-scale resting-state networks, relevance memory, links DA older individuals (n = 170, 64–68 years)....

ABSTRACT The dopamine (DA) system, particularly D1-like DA receptors (D1DR), declines across the adult life. functional consequences of reduced D1DR has been hypothesized to vary life periods, but precise timing these periods is unknown. To examine distinct phases in age-related reductions, we studied 180 healthy adults (90 females, 20-80 years), who underwent PET assessment using [ 11 C]SCH23390. A bi-phasic pattern differences was revealed, with an inflection point at approximately 40...

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e., gradients) persist across adult human lifespan, relate to memory molecular...

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e. gradients) persist across adult human lifespan, relate to memory molecular markers...

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of functional integration with neocortex, extending traditional framework emphasizing differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these (i.e., gradients) persist across adult human lifespan, relate to memory molecular...

Abstract Decades of research on functional brain mapping have highlighted the importance understanding organization cerebral cortex. Recent advances revealed a gradient spanning from primary sensory to transmodal cortices. This gradient-like axis connectivity has been hypothesized be aligned with regional differences in density neuromodulatory receptors. work non-human primates supports this notion, revealing dopamine D1-like receptor (D1DR) along cortical hierarchy. Given dopaminergic...

A key question in human neuroscience is to understand how individual differences brain function are related cognitive differences. However, the optimal condition of study between-person cognition remains unclear. Additionally, there a lack objective biomarkers accurately predict function, with age emerging as potential candidate. Recent research suggests that offers minimal additional information on decline beyond what chronological provides, prompting shift toward approaches focused...

Abstract Structural decline of the hippocampus occurs in heterogeneous patterns across its spatial extent, and is an important determinant episodic memory dysfunction aging. However, evidence indicate that anatomical landmark uncal apex, used to demarcate anterior posterior hippocampal subregions, changes position as atrophies. This emphasizes a risk misclassifying gray matter into incorrect subregion when using standard demarcation methods, contributing over- underestimation age effects on...