Abstract This study investigates the role of malic acid, a natural and environmentally friendly in optimizing crystallization process amoxicillin trihydrate (AMCT). For first time, effects acid on AMCT purity yield were systematically analyzed visualized using an Ishikawa diagram to elucidate complex interactions. Full factorial design multiple response optimization employed, with experiments conducted Minitab V19 software. The results demonstrated that concentration, pH, stirring speed...

This study investigates the use of environmentally friendly citric acid as main player in process, rather than an additive, to remove impurities from amoxicillin trihydrate (AMCT) crystals, aiming optimize their purity and yield. By manipulating concentration acid, mixing speed, crystallization time, pH, researchers conducted experiments using a full factorial design. The dissolution stage was analyzed both batch continuous processes, emphasizing significance enhancing crystallization. HPLC...

This study focuses on the detailed physical characterization of 4-HPG, a significant impurity found in some most commonly prescribed β-lactam antibiotics worldwide. Various analytical techniques, including X-ray powder diffractometry, dynamic light scattering, scanning electron microscopy, Fourier-transform infrared, and Raman spectroscopy, were employed to characterize properties 4-HPG crystals. XRD analysis revealed crystallinity small crystallite sizes particles, supported by DLS SEM...

Repeated crystallization or the use of different chemicals to obtain a pure crystal can cause yield/purity issues.

Amoxicillin is one of the broad-spectrumβ-lactam antibiotics widely used in treatment many diseases. It inevitable that 4-hydroxyphenylglycine (4-HPG) and 6-Aminopenicylanic acid (6-APA), which are during production this antibiotic, incorporated into molecular lattice product as impurities. Today, expensive methods chemical devices for purification by determining 6-APA 4-HPG, defined In study, it was aimed to develop a fast, simple, specific UV-spectrophotometric method determination 4-HPG...

Recycling of many polymers has gained a spectacular importance mainly because its environmental and economical benefits.Ethylene vinyl acetate is one the thermoplastics used directly as final product indirectly an additive within other polymeric materials.There been limited research work on recycling even though in industry shown growth last decade.It aim this study to investigate evaluate rheological behaviour ethylene-vinyl copolymer resin upon recycling.For purpose, original ethylene...

Today, with the globalization of world, traders have almost removed borders. Therefore, there has been a considerable increase in demand for people to reach each other. This also led maritime transport which approximately 80% volume worlds’ freight load and is most economical mode transportation. Despite being environmentally friendly system, current CO2 emission rate due sea 2.5%. Also, 26% emissions energy consumption resulting from transportation caused by container ships only generate...

Saf bir kristal ürün elde etmek için tekrar uygulanan kristalizasyon basamakları veya farklı kimyasallara başvurulması, bitmiş ürünün veriminde sorunlara neden olabilir. Bundan dolayı, ağın içerisindeki safsızlıklar, ana ürünü etkilemeden uzaklaştırılmalıdır. Bu çalışmada, Amoksisilin trihidrat (Amct) ve safsızlık olarak 4-hidroksifenilglisin (4-HPG) kullanılmıştır. Amct kafesinden, 4-HPG’nin yıkama yöntemleri kullanılarak uzaklaştırılması gösterilmiştir. Ayrıca, bu çalışmada ilk kez, verimi...

There is a current research tendency towards the biodegradable thermoplastic materials from renewable resources since environmental restraints play vital role in recent years.Starch one of and abundantly available form plant products.It possible to blend starch with various achieve such aims.In this study, an ethylene-vinyl acetate (EVA) copolymer resin (Luvax 40 W, DuPont) was blended modied (Maize Starch, Pendik Nisasta) amounts by means single screw extruder dierent speeds.For purpose,...

Bu çalışmada, etilen˗vinil asetat kopolimeri (ağırlıkça %40 vinil içeren, EVA 40W) ile ağırlıkça farklı oranlardaki organik kil (%0, 1, 3, 6 ve 8) (Nanocor I 44PT), nanokompozit elde etmek amacıyla şeffaf bir kovandan oluşan tek vidalı ekstruder içerisinde karıştırılarak

Bulk molding compound (BMC) is one of the important composite materials with various engineering applications. BMC a thermoset plastic resin blend inert fillers, fiber reinforcements, catalysts, stabilizers and pigments that form viscous, compound. Depending on end-use application, bulk compounds are formulated to achieve close dimensional control, flame scratch resistance, electrical insulation, corrosion stain superior mechanical properties, low shrink color stability. Its excellent flow...

Almost one-third of the world's maritime trade is carried out by tankers. It important to understand chemical hazard awareness seafarers on tankers, take precautions against risks that may occur, and be able eliminate missing information. This study was performed ascertain about exposure in tanker transports. To this end, a survey containing 24 questions consisting duration seafarers' awareness, knowledge, health knowledge created order evaluate seafarers. Cronbach's Alpha reliability test...