A5027465885- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sepsis Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Intensive Care Unit Cognitive Disorders
- Asthma and respiratory diseases
- Hemodynamic Monitoring and Therapy
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- High Altitude and Hypoxia
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Infrared Thermography in Medicine
- ECG Monitoring and Analysis
- Neurological disorders and treatments
- Reproductive Health and Contraception
- Takotsubo Cardiomyopathy and Associated Phenomena
- Fungal Infections and Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrest and Resuscitation
- Ultrasound in Clinical Applications
- Neutropenia and Cancer Infections
- Obstructive Sleep Apnea Research
- Inflammatory Myopathies and Dermatomyositis
- Ectopic Pregnancy Diagnosis and Management
- Hereditary Neurological Disorders
Loma Linda University
2017-2025
Riverside University Health System - Medical Center
2021-2024
University of California, Riverside
2023
Loma Linda University Children's Hospital
2019-2022
VA Loma Linda Healthcare System
2021
University of Arizona
2016-2018
Easton Hospital
2012-2015
Drexel University
2012-2014
Abstract This study aimed to evaluate discordance, binary classification, and model fit between race‐predicted race‐neutral spirometry prediction equations. Spirometry data from 9506 patients (18–95 years old) self‐identifying as White, Black, or Hispanic were analyzed, focusing on the lower limit of normal (LLN). Best‐fit equations developed 3771 with spirometry, using Bayesian Information Criterion (BIC) compare models without race a covariate. Results showed that including covariate...
Background: Dyspnea is frequently a debilitating symptom in chronic obstructive pulmonary disease (COPD).Cannabinoid receptor agonists have potential to alter dyspnea these patients.Objective: To determine if dronabinol, pure cannabinoid, improves and exercise tolerance COPD. Methods:In this double-blind randomized, cross-over pilot study, COPD patients received up 20mg oral dronabinol or placebo daily for six weeks with an intervening washout period.Dyspnea fatigue were assessed using Borg...
In an anaesthetised animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation. humans, arterial pressure is positively related to basal muscle sympathetic nerve activity (MSNA) under conditions where elevated evident (e.g. high altitude); however, a causal link not established. Using novel experimental approach, we demonstrate that reducing lowers MSNA healthy humans. This response distinct from negative feedback mediated by aortic and...
Objective The passive leg raising (PLR) maneuver has become standard practice in fluid resuscitation. We aim to investigate the precision and consistency of PLR for determining responsiveness critically ill patients healthy volunteers using bioreactance non-invasive cardiac output monitoring (NiCOM™, Cheetah Medical, Inc., Newton Center, Massachusetts, USA). Methods This study is prospective, single-center, observational cohort with repeated measures admitted medical intensive care unit at a...
Chronic obstructive pulmonary disease (COPD) patients have poor sleep quality, longer time to onset and frequent nocturnal awakenings. Poor quality in COPD is associated with of life (QoL), increased exacerbations mortality. Pulmonary rehabilitation (PR) improves functional status QoL but effects on are unclear. PR subjective there paucity objective actigraphy data. We hypothesized that would demonstrate improvement following PR. Paired comparisons (t-test or Wilcoxon-signed-rank test) were...
Myotonic dystrophy (DM) is an inherited progressive muscle disorder caused by defects in proteins. As the incidence of this condition low, not many are familiar with multisystem involvement. At times, cardiac disease may even be predominant manifestation form arrhythmias, conduction defects, and cardiomyopathies. The progression can lead to sudden, unpredictable death. Thus, it important identify subgroup treat accordingly.To patients DM assess their risk for sudden death.Nine previously...
Excessive decrease in the flow of late expiratory portion a volume loop (FVL) or “flattening”, reflects small airway dysfunction. The assessment flattening is currently determined by visual inspection pulmonary function test (PFT) interpreters and highly variable. In this study, we developed an objective measure to quantify flattening. We downloaded 172 PFT reports PDF format from electronic medical records digitized extracted FVL. located point A (the peak flow), B corresponding 75% vital...
A 50-year-old woman presented with a three-month history of nonpruritic skin rash, weakness and myalgia. The which preceded the weakness, started on her face spread to back, but spared mucous membranes. Strength in bilateral upper lower extremities was decreased,
Sepsis mortality has remained unchanged for greater than a decade, and early recognition continues to be the most important factor in outcome. Plasma resistin concentration is increased sepsis, but its mechanism clinical relevance unclear. As one function, interacts with toll-like receptor 4 competition lipopolysaccharide, main component of gram-negative bacterial cell wall. It not known if type infection leading sepsis influences production. The objective this study was investigate whether...
Background: The role of noninvasive positive pressure ventilation (NIPPV) in acute asthma exacerbation is controversial. However, the outcome NIPPV obese patients with during such has not been well studied despite well-established relationship between obesity and asthma. Study Question: Does body mass index (BMI) play a an does it predict success or failure NIPPV? Design: study was retrospective analysis by design. purpose to assess factors predicting NIPPV. entire cohort divided into 2...
Background. Widespread drug shortages led to higher utilization of ketamine in our intensive care unit, especially among patients with SARS-CoV-2. Objectives. To evaluate the impact continuous infusion on vasopressor requirements Method. This was a single-center, retrospective, cohort study comparing mechanically ventilated (MV), adult SARS-CoV-2 receiving either propofol or for at least 72 hours. Results. 84 (mean age 61-year-old, 68% male) were analyzed. 31 received ketamine, and 53...
Foster, Katharine, James D. Anholm, Gary Suman Thapamagar, and Prajan Subedi. Effects of naltrexone on sleep quality periodic breathing at high altitude.
Chronic dyspnoea and exercise impairment are common after acute pulmonary embolism (PE) but not defined quantified sufficiently to serve as outcomes in clinical trials. The planned project will clinically validate a novel method determine discrete, meaningful diagnoses PE. uses an algorithm entitled SEARCH, for symptom screen, testing, arterial perfusion, resting echocardiography, confirmatory imaging haemodynamic measurements. SEARCH is stepwise that sorts patients by hierarchical series of...
Introduction: The American Diabetes Association recommends that either normal (NS) or half-normal (1/2NS) saline be administered continuously until resolution of DKA. Recently, there has been increasing interest in optimal intravenous (IV) fluid selection for resuscitative purposes, sparked by an association between NS and acute kidney injury (AKI). However, is little data pertaining to its effect on clinical outcomes Protocols at our institution require lactated ringers (LR) 1/2NS as...
Cohen, Avi; Tan, Laren; Fargo, Ramiz; Anholm, James; Gasho, Christopher; Chopra, Sahil; Hansen, Jennifer; Thapamagar, Suman; Yaqub, Kashif; Huang, Cynthia; Moretta, Dafne; Washburn, Destry; Specht, Lennard; Nguyen, Bryant Author Information
Thompson, Jordan; Chopra, Sahil; Shahangian, Sean; Moretta, Dafne; Yaqub, Kashif; Thapamagar, Suman; Nguyen, Bryant Author Information