A5077040926- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Urticaria and Related Conditions
- Ion Channels and Receptors
- Veterinary Oncology Research
- Sphingolipid Metabolism and Signaling
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Lipid Membrane Structure and Behavior
University of Veterinary Medicine Hannover, Foundation
2009-2021
University of Veterinary Medicine
2020
University of Veterinary Medicine Vienna
2008-2015
Fraunhofer Institute for Toxicology and Experimental Medicine
2010
Abstract: Effects of the histamine H 4 receptor antagonist JNJ 7777120 (1‐[(5‐chloro‐1 ‐indol‐2‐yl)carbonyl]‐4‐methylpiperazine) were tested in two models allergic contact dermatitis. Dermatitis was induced by 2,4‐dinitrochlorobenzene and toluene‐2,4‐diisocyanate, which differ their Th1–Th2 profile that way is a classical allergen with pronounced Th1‐mediated inflammation, while respiratory chemical toluene‐2,4‐diisocyanate induces Th2‐dominated inflammation. (15 mg/kg) administered 2 h 30...
Two histamine receptor subtypes (HR), namely H1R and H4R, are involved in the transmission of histamine-induced itch as key components. Although exact downstream signaling mechanisms still elusive, transient potential (TRP) ion channels play important roles sensation histaminergic non-histaminergic itch. The aim this study was to investigate involvement TRPV1 TRPA1 inhibitors modulate H1R- H4R-induced signal tested a scratching assay mice vivo well via Ca
Histamine is an important mediator of allergic reactions, and recent studies indicated that the function different types antigen presenting cells (APC) can be modulated by histamine, in particular via newly described histamine H(4) receptor (H(4)R). Therefore, we investigated possible interactions H(4)R on Langerhans (LC), which represent professional APC skin therefore have role initiation maintenance diseases.The expression was evaluated real-time PCR, flow cytometry immunofluorescence...
The histamine H4 receptor (H4R) was brought into focus as a new therapeutic target for the treatment of allergic disorders such atopic dermatitis (AD). H4R antagonists have already been tested in several animal models AD, but these studies yielded conflicting results.The development ovalbumin-induced AD-like skin lesions analysed H4R(-/-) mice and antagonist (JNJ28307474)-treated mice.H4R(-/-) showed clear amelioration lesions, with diminished influx inflammatory cells reduced epidermal...
Abstract Histamine is a well known mediator of allergic skin diseases and, with the discovery histamine H 4 receptor, role re‐evaluated. There are only limited published data elucidating receptor in dogs. Twelve beagles intradermally injected (0.25 μmol and 2.5 μmol/site) reacted classical wheal flare reaction. None dogs showed signs pruritus. The reaction after intradermal injection agonist/H 3 antagonist clobenpropit (0.1 μmol) selective agonist VUF 8430 (1.5 μmol). Again, no scratching...
Background Mapracorat is a nonsteroidal Selective Glucocorticoid Receptor Agonist ( SEGRA ) that presumed to have better therapeutic index compared classical glucocorticoids. Objectives To compare the efficacy and safety of mapracorat with glucocorticoids used for treatment allergic skin diseases in dogs. Animals Six laboratory beagles. Methods The effect on lipopolysaccharide‐induced TNF α secretion from canine peripheral blood derived mononuclear cells PBMC was tested. In vivo ,...
Background Various mediators are involved in the induction of itch, i.e. pruritus; however, vivo pharmacology pruritus seems to be different distinct species, and little is known about receptors that itch dogs. The species differences mediation might explained by receptor expression sensory nerves, including dorsal root ganglia ( DRG ). Hypothesis/Objectives aim study was analyse for various canine . Methods Dorsal 14 dogs, which were euthanized reasons not related this study, analysed....
Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied itch. Histamine, acting via histamine 1-4 receptors, known to modulate responses in induce The aim of this study was test role 2 receptors 4 imiquimod-induced psoriasis-like inflammation model. BALB/c mice were treated intraperitoneally with amthamine (histamine receptor agonist), JNJ-39758979 antagonist), combination both, or...