A5065898164- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Lysosomal Storage Disorders Research
- Plant and Fungal Interactions Research
- Plant Virus Research Studies
- Erythrocyte Function and Pathophysiology
- Lipid Membrane Structure and Behavior
- Endoplasmic Reticulum Stress and Disease
- Carbohydrate Chemistry and Synthesis
- Microtubule and mitosis dynamics
- Lipid metabolism and biosynthesis
- Cancer, Lipids, and Metabolism
- Neurobiology and Insect Physiology Research
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Invertebrate Immune Response Mechanisms
- ATP Synthase and ATPases Research
- Emotion and Mood Recognition
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Biochemical Acid Research Studies
- Skin and Cellular Biology Research
National Cancer Institute
2014-2024
Office of Extramural Research
2019-2023
Indian Institute of Science Bangalore
2010-2014
T helper 17 (T
Seizures induced by visual stimulation (photosensitive epilepsy; PSE) represent a common type of epilepsy in humans, but the molecular mechanisms and genetic drivers underlying PSE remain unknown, no good animal models have been identified as yet. Here, we show an model PSE, Drosophila, owing to defective cortex glia. The glial membranes are severely compromised ceramide phosphoethanolamine synthase (cpes)-null mutants fail encapsulate neuronal cell bodies Drosophila cortex. Expression human...
Abstract Pancreatic β cells secrete insulin in response to glucose elevation maintain homeostasis. A complex network of inter-organ communication operates modulate secretion and regulate levels after a meal. Lipids obtained from diet or generated intracellularly are known amplify glucose-stimulated secretion, however, the underlying mechanisms not completely understood. Here, we show that Drosophila secretory lipase, Vaha (CG8093), is synthesized midgut moves brain where it concentrates...
Sesbania mosaic virus (SeMV) is a positive stranded RNA belonging to the genus Sobemovirus. Construction of an infectious clone essential step for deciphering gene functions in vivo. Using Agrobacterium based transient expression system we show that SeMV icDNA on grandiflora and Cyamopsis tetragonoloba plants. The efficiency infection was found be significantly high plants when compared grandiflora. coat protein could detected within 6 days post infiltration infiltrated leaves. Different...
The coat protein II (COPII)–coated vesicular system transports newly synthesized secretory and membrane proteins from the endoplasmic reticulum (ER) to Golgi complex. Recruitment of cargo into COPII vesicles requires an interaction either with molecules directly or receptors for anterograde trafficking. We show that cytosolic phosphatidic acid phospholipase A1 (PAPLA1) interacts family members is required transport Rh1 (rhodopsin 1), N-glycosylated G protein–coupled receptor (GPCR), ER In...
Cell division, wherein 1 cell divides into 2 daughter cells, is fundamental to all living organisms. Cytokinesis, the final step in begins with formation of an actomyosin contractile ring, positioned midway between segregated chromosomes. Constriction ring concomitant membrane deposition a specified spatiotemporal manner generates cleavage furrow that physically separates cytoplasm. Unique lipids specific biophysical properties have been shown localize intercellular bridges (also called...
Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism replication. Sesbania mosaic virus (SeMV) RdRp was shown to strongly p10 domain polyprotein 2a and moderately protease domain. Mutational analysis suggested C-terminal disordered involved in interaction p10. Coexpression full length resulted formation RdRp-p10 complex which showed significantly higher activity than alone. Interestingly, CΔ43...
All living organisms require the division of a cell into daughter cells for their growth and maintenance. During division, both genetic cytoplasmic contents are equally distributed between two cells. At end plasma membrane physically separated via process known as cytokinesis. Hundreds proteins lipids involved in cytokinetic have been identified; however, much less is about mechanisms by which these molecules regulate cytokinesis, being therefore an intense area current research. Male...
Abstract Cell division, wherein one cell divides into two daughter cells, is fundamental to all living organisms. Cytokinesis, the final step in begins with formation of an actomyosin contractile ring, positioned midway between segregated chromosomes. Constriction ring concomitant membrane deposition a spatiotemporal manner generates cleavage furrow that physically separates cytoplasm. Unique lipids specific biophysical properties have been shown localize intercellular bridges (also called...