A5078622783- Colorectal Cancer Screening and Detection
- Neuroscience and Neural Engineering
- Genomics and Chromatin Dynamics
- Ophthalmology and Eye Disorders
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Photoreceptor and optogenetics research
- Single-cell and spatial transcriptomics
- Planarian Biology and Electrostimulation
- Nanoparticle-Based Drug Delivery
- Intraocular Surgery and Lenses
- Colorectal Cancer Treatments and Studies
- Pancreatitis Pathology and Treatment
- Ophthalmology and Visual Impairment Studies
- Scoliosis diagnosis and treatment
- Diagnosis and treatment of tuberculosis
- Conducting polymers and applications
- Whipple's Disease and Interleukins
- Parathyroid Disorders and Treatments
- Multiple Sclerosis Research Studies
- Transgenic Plants and Applications
- Cell Image Analysis Techniques
- Children's Physical and Motor Development
University of Southern California
2024-2025
Southern California Eye Institute
2025
Keck Hospital of USC
2024
University of California, Berkeley
2021-2023
Dartmouth College
2022
University of California, Davis
2020
Scripps Clinic
2018-2019
Scripps Green Hospital
2019
University of California, Los Angeles
2011-2019
UCLA Health
2019
Although the aspect ratio (AR) of engineered nanomaterials (ENMs) is one key physicochemical parameters that could determine biological outcome, not much understood about how AR contributes to shaping outcome. By using a mesoporous silica nanoparticle (MSNP) library has been constructed cover range different lengths, we demonstrate rod-shaped particles determines rate and abundance MSNP uptake by macropinocytosis process in HeLa A549 cancer cell lines. MSNPs with an 2.1–2.5 were taken up...
Failure of central nervous system (CNS) axons to regenerate after injury results in permanent disability. Several molecular neuro-protective and neuro-regenerative strategies have been proposed as potential treatments but do not provide the directional cues needed direct target-specific axon regeneration. Here, we demonstrate that applying an external guidance cue form electric field stimulation adult rats optic nerve crush was effective at directing long-distance, retinal ganglion cell...
This paper describes a novel synthetic approach for the conversion of zero-valent copper metal into conductive two-dimensional layered metal-organic framework (MOF) based on 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) to form Cu
Genomic deep learning models can predict genome-wide epigenetic features and gene expression levels directly from DNA sequence. While current perform well at predicting across genes in different cell types the reference genome, their ability to explain variation between individuals due cis-regulatory genetic variants remains largely unexplored. Here, we evaluate four state-of-the-art on paired personal genome transcriptome data find limited performance when explaining individuals. In...
Abstract Genomic deep learning models can predict genome-wide epigenetic features and gene expression levels directly from DNA sequence. While current perform well at predicting across genes in different cell types the reference genome, their ability to explain variation between individuals due cis-regulatory genetic variants remains largely unexplored. Here we evaluate four state-of-the-art on paired personal genome transcriptome data find limited performance when explaining individuals.
Background and aims: Post-ERCP complications increase with repeated attempts at cannulation. We evaluated several advanced biliary cannulation techniques applied when the standard approach fails. Methods: In total, 1873 consecutive patients underwent ERCP our institution during period 2010 - 2014. Guidewire-assisted (GA) no contrast injection until deep was considered technique. Advanced used were double wire-guided (DWG) cannulation, transpancreatic papillary septotomy (TPS), needle-knife...
Accurate methods for tracking individuals are crucial to the success of fisheries and aquaculture management. Management migratory salmonid populations, which important health many economies, ecosystems, indigenous cultures, is particularly dependent on data gathered from tagged fish. However, physical tagging currently used have challenges including cost, variable marker retention, information limited individuals. Genetic combat problems associated with tags, but their own high potentially...
Flow cytometry (FCM) is an analytic technique that capable of detecting and recording the emission fluorescence light scattering cells or particles (that are collectively called "events") in a population1. A typical FCM experiment can produce large array data making analysis computationally intensive2. Current platforms (FlowJo3, etc.), while very useful, do not allow interactive processing online due to size limitations. Here we report more effective way analyze on web. Freecyto free...
To characterize the prevalence of astigmatism among heretofore largest published sample preschool children and to do so different age, gender, racial ethnic subgroups.
Introduction: Transoral incisionless fundoplication (TIF) has been shown to improve symptomatic outcomes in chronic refractory GERD. However, patients with large hiatal hernias have typically excluded due difficulty endoscopic reduction. Data is limited on the use of combined TIF laparoscopic hernia repair. We aimed evaluate and safety hybrid TIF. Methods: TIFs performed using EsophyX device from February 1, 2011 December 31, 2014 were evaluated for patient demographics, prior studies (EGD,...
INTRODUCTION: Mycobacterium tuberculosis is estimated to infect 1.7 billion people worldwide. When untreated, disseminated can occur through hematogenous seeding from primary infection or reactivation of latent disease. Abdominal be seen in 5% cases worldwide, with complications such as bowel obstruction resulting localized tuberculous lymphadenopathy. We present a patient history who presented secondary calcified mesenteric CASE DESCRIPTION/METHODS: An 82-year old woman was initially...
Background: Neuromyelitis optica spectrum disease (NMOSD) and multiple sclerosis (MS) share clinical presentations including optic neuritis brainstem syndromes. Internuclear ophthalmoplegia (INO) is characterized by slowed ipsilateral adduction saccades results from a lesion in the medial longitudinal fasciculus (MLF). Although INO common finding MS, its prevalence NMOSD unknown. The objective of this work to determine comparative frequencies patients with MS compare features both processes....
Purpose: Gastric mucosal calcinosis (GMC) is a rare cause of gastrointestinal bleeding, and usually an incidental finding on endoscopy. Histopathology characteristically reveals deposits irregular, amorphous microcalcifications in the gastric mucosa. GMC classified as metastatic, dystrophic or idiopathic. Metastatic most common, occurring setting abnormal calciumphosphate metabolism, resulting deposition calcium salts. We report case associated with overt bleed. Case: A 59 year old Hispanic...
Introduction: Hemobilia, defined as hemorrhage into the biliary tract, is caused by a pathological communication between hepatic vessels and bile ducts. The most common etiology of hemobilia trauma, followed gallstones, inflammatory diseases, vascular lesions, neoplasms. Hemobilia classically presents clinical triad colic, jaundice, upper gastrointestinal tract bleed, though typical symptoms are only found in about 40% cases. Acute pancreatitis an unusual presentation hemobilia. proposed...
Purpose: Whipple's disease is a rare systemic infection caused by Tropheryma whipplei, gram-positive bacillus. It more commonly affects Caucasian males with median age of 49 years at diagnosis. Presenting manifestations include arthralgias, weight loss, diarrhea, and abdominal pain. Endoscopic exam the small bowel typically reveals pale yellow plaques nodules, erythematous spots, punctate subepithelial hemorrhages. Definitive diagnosis made biopsy. We present case erosive presenting melena...
Collagenous colitis, a type of microscopic is characterized by endoscopically normal colonic mucosa with thickened subepithelial collagenous band on histopathology. Rarely, coexistent colitis and inflammatory bowel disease have been reported. We report case patient history subsequent development Crohn's followed recurrent while anti-tumor necrosis factor therapy. A 71-year-old woman hypertension hypothyroidism presented 2 months watery, nonbloody diarrhea, intermittent abdominal cramping, 5...
e15079 Background: With increasing life expectancy, the incidence of colorectal cancer increases. Currently, there are few studies on outcomes outpatient colonoscopy in patients older than 85 years age. Methods: The database at Scripps was queried for all colonoscopies performed under moderate sedation between April 1, 2012 to March 31, 2017 aged and older. Patient demographics, indication procedure, endoscopic findings were obtained. Variables including location stage tumor, subsequent...