A5055602751- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Complement system in diseases
- Hemophilia Treatment and Research
- Platelet Disorders and Treatments
- Extracellular vesicles in disease
- Orthopaedic implants and arthroplasty
- Peripheral Neuropathies and Disorders
- Multiple Myeloma Research and Treatments
- Hedgehog Signaling Pathway Studies
- MicroRNA in disease regulation
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease and Transplantation
- Electronic Health Records Systems
- Autoimmune Bullous Skin Diseases
- Dialysis and Renal Disease Management
- Erythropoietin and Anemia Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neurological Complications and Syndromes
- Eosinophilic Disorders and Syndromes
University of Milan
2023-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024
KU Leuven
2023
The Ohio State University
2023
University of Padua
2021
Università Cattolica del Sacro Cuore
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Early diagnosis of joint damage is pivotal in haemophilia to prevent the occurrence and progression haemophilic arthropathy thus providing optimal personalised management. The health score version 2.1 (HJHS) based on a physical examination mainly affected joints. Musculoskeletal ultrasound has demonstrated capability detect early changes terms synovitis osteochondral damage. detection with (HEAD-US) been proposed as simple reliable evaluation tool.
Sonic hedgehog (Shh) is a prototypical angiogenic agent with crucial role in the regulation of angiogenesis. Experimental studies have shown that Shh upregulated response to ischemia. Also, may be found on surface circulating microparticles (MPs) and MPs bearing (Shh + MPs) ability contribute reparative neovascularization after ischemic injury mice. The goal this study was test hypothesis that, humans peripheral artery disease (PAD), there increased number MPs. This done by assessing plasma...
significantly reduced total and mature thrombocyte counts (Fig. 1A-C), recapitulating the clinical presentation of hereditary thrombocytopenia in patients.Additionally, ankrd26-overexpressing zebrafish mutants background Adamts13 deficiency present a further reduction than with or Ankrd26 overexpression alone 1D-F).Moreover, iTTP patients, platelets plasma ANKRD26 levels were increased compared those non-iTTP controls 1G-H).Finally, PRMT1, an arginine methyltransferase for RUNX1 which is...
Figure 1: A) ADAMTS13 and multiplex FRET VWF71 peptide substrates.Amino acid residues between the human VWF domain A2 (H-71) cattle sequence (C-71) were sequentially swapped to make chimeric peptides P3-P10.The M, D, C, S exosites that extensive contacts with unfolded (VWF Q1599 -R1668) are shown by dotted lines shaded boxes.QC-1 DyL633 quencher fluorophore, respectively.B) The Dand C-binding sites in cannot be combined without negatively affecting rate of cleavage.An equal amount (plasma or...
so as to timely notice ADAMTS13 relapse and prevent clinical relapse.