A5033416715- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Total Knee Arthroplasty Outcomes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Cell Adhesion Molecules Research
- Respiratory viral infections research
- Orthopaedic implants and arthroplasty
- IL-33, ST2, and ILC Pathways
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Hip disorders and treatments
- Lysosomal Storage Disorders Research
- Orthopedic Infections and Treatments
- Cardiac Valve Diseases and Treatments
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Complement system in diseases
- Trypanosoma species research and implications
King's College London
2018-2019
Imperial College London
2010-2016
Asthma UK
2016
National Institutes of Health
2013
Center for Rheumatology
2012
Orthopaedic Research
2008
Epsom Hospital
2008
William Harvey Hospital
2008
Luton and Dunstable Hospital
2008
University Hospital Llandough
1986
We audited the relationship between obesity and age at which hip knee replacement was undertaken our centre. The database analysed for age, Oxford or score body mass index (BMI) time of surgery. In total, 1369 patients were studied, 1025 treated by 344 replacement. divided into five groups based on their BMI (normal, overweight, moderately obese, severely obese morbidly obese). difference in mean surgery not statistically significant (p > 0.05). For those undergoing replacement, ten years...
ABSTRACT Effector T-cells rely on integrins to drive adhesion and migration facilitate their immune function. The heterodimeric transmembrane integrin LFA-1 (αLβ2 integrin) regulates of effector through linkage the extracellular matrix with intracellular actin treadmill machinery. Here, we quantified velocity direction F-actin flow in migrating alongside single-molecule localisation LFA-1. Results showed that retrograde positively correlated immobile negatively T-cell velocity. Plasma...
Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory cells are thought be a primarily helper 1 type, but both and 2 memory have been described, heightened 2/ lessened associated with increased RV-induced asthma exacerbation severity. We examined the contribution airways inflammation using mice deficient in transcription factor T-Box Expressed In Cells (Tbet), critical controller cell differentiation. Using flow cytometry we...
African trypanosomes (Trypanosoma brucei spp.) are extracellular, hemoflagellate, protozoan parasites. Mammalian infection begins when the tsetse fly vector injects into skin during blood feeding. The then reach draining lymph nodes before disseminating systemically. Intravital imaging of post-tsetse bite revealed that were observed both extravascularly and intravascularly in lymphatic vessels. Whether host-derived cues play a role attraction towards vessels to aid their dissemination from...
Abstract Effector T-cells rely on integrins to drive adhesion and migration facilitate their immune function. Heterodimeric transmembrane integrin LFA-1 (αLβ2) regulates through linkage of the extracellular matrix with intracellular actin treadmill machinery. We quantitated velocity direction F-actin flow in migrating alongside single molecule localisation LFA-1. Our results show that retrograde positively correlated immobile negatively T-cell velocity. Plasma membrane localised forms unique...
Summary: In 42 subjects with chronic obstructive lung disease receiving oral theophylline therapy, the venous whole blood concentration was closely related to total plasma concentrations (r = 0.976, p > 0.001). The blood/plasma ratio 0.85 ± 0.13 and not haematocrit or free fraction of in plasma. red cell numerically similar concentration. This indicates that is most important determinant concentration, binding drug by cells active uptake into erythrocytes unlikely occur. Whole can be used...