A5103060933- Receptor Mechanisms and Signaling
- Cell Image Analysis Techniques
- Digestive system and related health
- Infant Nutrition and Health
- Distributed systems and fault tolerance
- Chemical Synthesis and Analysis
- Image Processing Techniques and Applications
- Biomedical Text Mining and Ontologies
- Parallel Computing and Optimization Techniques
- Computational Drug Discovery Methods
- Distributed and Parallel Computing Systems
- RNA Interference and Gene Delivery
- Digital Imaging for Blood Diseases
- Cancer Genomics and Diagnostics
- Mass Spectrometry Techniques and Applications
- Smart Agriculture and AI
- Pediatric health and respiratory diseases
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Single-cell and spatial transcriptomics
- Lung Cancer Research Studies
- Molecular Junctions and Nanostructures
- Protein Structure and Dynamics
- Probiotics and Fermented Foods
- Neuropeptides and Animal Physiology
Cedars-Sinai Medical Center
2021-2025
University of Colorado Denver
2023-2025
California State University, Northridge
2019-2022
Institute of Biomedical Science
2022
Universitat Politècnica de València
2010-2015
Instituto de Instrumentación para Imagen Molecular
2015
Ayuntamiento de Valencia
2010
Akkermansia muciniphila is a mucin-degrading bacterium found in the human gut and often associated with positive health. However, despite being detected by as early 1 month of age, little known about role infant gut. Human milk oligosaccharides (HMOs) are abundant components structurally similar to that comprise mucin, preferred growth substrate human-associated Akkermansia. A limited subset intestinal bacteria has been shown grow well on HMOs mucin. We therefore examined ability genomically...
Abstract In profiling assays, thousands of biological properties are measured in a single test, yielding discoveries by capturing the state cell population, often at single-cell level. However, for datasets, it has been challenging to evaluate phenotypic activity sample and consistency among samples, due profiles’ high dimensionality, heterogeneous nature, non-linear properties. Existing methods leave researchers uncertain where draw boundaries between meaningful response technical noise....
Advances in high-throughput microscopy have enabled the rapid acquisition of large numbers high-content images. Whether by deep learning or classical algorithms, image analysis pipelines then produce single-cell features. To process these single-cells for downstream applications, we present Pycytominer, a user-friendly, open-source python package that implements bioinformatics steps, known as image-based profiling. We demonstrate Pycytominers usefulness machine project to predict nuisance...
Today, there is much knowledge that not exploited from the clinical records thousands of patients treated at different centres. In part, this because traditional databases fail revealing undiscovered correlations can contribute to improve outcomes and reduce costs patient care. This paper presents a new graph processing framework for data, which leverage cloud computing address large-scale studies. Also, case study breast cancer with relevance practice presented. successfully addressed using...
G protein‐coupled receptors (GPCRs) are known to possess multiple active conformational states in nature, however, studying these conformations is extremely challenging as majority of the functionally important have high energy compared lowest conformation. We developing a method called Enhanced Conformational Markov‐state Sampling Membrane BiLayer Environment (EnCoMSeMBLE) that would enhance our search landscape GPCRs and can be applied a‐helical transmembrane proteins general. It enables...
G protein coupled receptors (GPCRs) are integral membrane proteins that enable a cell to respond extracellular stimuli like light, small molecules, peptides, and proteins. These have evolved as highly flexible possess multiple functionally important conformational states, which these activate pleiotropic signaling events inside the cells. Recent progress in structural biology techniques cryo‐electron microscopy is providing evidence of two or more distinct receptor conformations for...
G protein coupled receptors (GPCRs) are integral membrane proteins that allow a cell to convert extracellular stimuli like light, small molecules, peptides, and into intracellular signals. These conformationally very malleable, which is necessary for their different functional states. Recent developments in the structural biology of utilization other biophysical techniques GPCRs generating rich evidence existence multiple receptor conformations. Different conformations thought be responsible...
Abstract Triple-negative breast cancer (TNBC) lacks selective biomarkers targeted by current clinical therapies and often metastasizes to the brain. Crossing blood-brain barrier (BBB) reaching intracranial tumors is a challenge contributing poor prognoses for patients. The human epidermal growth factor receptor HER3 has emerged as biomarker of metastasis may provide means therapeutically targeting TNBC. We have developed HER3-targeted biological particles (bioparticles) that exhibit systemic...
ABSTRACT Crossing the blood-brain barrier (BBB) and reaching intracranial tumors is a significant clinical challenge for targeted therapeutics contributes to poor prognosis most patients with brain malignancies. Triple-negative breast cancer (TNBC) has high propensity metastasis lacks cell surface markers that can be recognized by current therapies used in clinic, thus limiting therapeutic options. The human epidermal growth factor receptor HER3 (or ErbB3) emerged as biomarker of resistance...
Abstract Akkermansia muciniphila are mucin degrading bacteria found in the human gut and often associated with positive health. However, despite being detected as early one month of age, little is known about role infant gut. Human milk oligosaccharides (HMOs) abundant components structurally similar to that comprise mucin, preferred growth substrate human-associated . A limited subset intestinal has been shown grow well on HMOs mucin. We therefore examined ability genomically diverse...