A5013155250- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Metal complexes synthesis and properties
- Bacteriophages and microbial interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- RNA modifications and cancer
- RNA Research and Splicing
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Nanowire Synthesis and Applications
- Enzyme Structure and Function
- Quantum Dots Synthesis And Properties
- Radiation Detection and Scintillator Technologies
- Luminescence Properties of Advanced Materials
- Crystal structures of chemical compounds
- Anodic Oxide Films and Nanostructures
- Biopolymer Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
China Pharmaceutical University
2025
Nanjing Medical University
2014-2024
Jiangxi University of Science and Technology
2023
Stanford University
2010-2020
Nanjing Tech University
2014-2015
Scripps Research Institute
2009
Heilongjiang Provincial Hospital
2008
Nankai University
2005-2007
University of Toronto
2005-2007
Universitat de Barcelona
2005
To investigate the influences of geometries pendant carboxylate ligands and some intramolecular/intermolecular weak interactions on structures transition metal complexes, five new Cd(II) Cd2(HL1)2(L2)4 (1), Cd2(HL1)2(L3)4 (2), {[Cd2(HL1)(L4)4(H2O)2](H2O)}∞ (3), [Cd(L1)(L5)]∞ (4), Cd2(L1)2(HL1)2(L4)2 (5) (HL1 = 3-(2-pyridyl)pyrazole, HL2 benzoic acid, HL3 naphthalene-carboxylic HL4 9-anthracene-carboxylic HL5 isonicotinic acid), have been synthesized structurally characterized by elemental...
We have successfully prepared CdSe nanowire arrays by direct-current electrodeposition in porous anodic aluminum oxide templates from a dimethyl sulfoxide solution containing CdCl2 and elemental Se. Electron microscopy results show that the length, diameter, direction of growth nanowires are quite uniform. X-ray energy dispersion analysis indicates atomic composition Cd Se is very close to 1:1 stoichiometry. Furthermore, diffraction high-resolution electron microscope investigations...
Seven new Cu(II) complexes based on a binuclear planar unit [Cu(mu-L(1))](2), [[Cu(mu-L(1))(NO(3))(H(2)O)](2) (1), [Cu(mu-L(1))(HL(1))(ClO(4))](2) (2), [Cu(4)(mu-L(1))(6)(NO(3))(2)] (3), [Cu(4)(mu-L(1))(6)(L(1))(2)] (4), [Cu(4)(mu-L(1))(6)(mu-L(2))](n) (5), [Cu(4)(mu-L(1))(6)(mu-L(3))](n) (6), [[Cu(4)(mu-L(1))(4)(mu-L(4))(2)](H(2)O)(3)](n) (7) (HL(1) = 3-(2-pyridyl)pyrazole, L(2) 1,8-naphthalenedicarboxylate, L(3) terephthalate, L(4) 2,6-pyridinedicarboxylate)}, have been synthesized and...
Abstract II-VI group compound semiconductors such as CdS, CdSe, and CdTe nanowire arrays have been prepared by direct current electrodeposition in porous anodic aluminum oxide template from nonaqueous electrolyte. SEM TEM results show that these nanowires a highly anisotropic structure of aligned with diameters 15-200 nm, which are consistent the templates used. Electron diffraction HREM investigations demonstrate crystalline structures uniform hexagonal single crystal. This approach can be...
The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed human GC. Functionally, verified promoted tumor cell proliferation and angiogenesis through a series phenotypic experiments. Subsequently, ADAMTS9 identified as the downstream effector GC, could be degraded by YTHDF2-dependent pathway. Finally, data suggested might facilitate GC progression...
Significance Deformation of the double helix is a ubiquitous feature protein–DNA interactions that regulate, replicate, repair, and pack DNA in cells. Understanding energetics deformation therefore central importance. generally modeled as linear elastic rod, but it has not been possible to test this directly by observing nanometer-scale bending twisting helix. Using an X-ray interferometry technique, we measured structural fluctuations short B-form duplex. The results expose potential...
Significance Obtaining the conformational ensembles of biological macromolecules, beyond average structures, is extremely challenging but necessary for a complete understanding their folding and functions. Such insights may also lead to rational design therapeutics that can target less-ordered macromolecules advance nanostructures nanomachines from nucleic acids. We have applied X-ray interferometry estimate ensemble small-model macromolecule, DNA bulge, representative helix–junction–helix...
Synthetic cannabinoids (SCs), a class of widely abused new psychoactive substances, are characterized by their structural diversity and rapid evolution. Structure–affinity relationships crucial for predicting pharmacological effects potential toxicity. Traditional methods affinity testing often complex less applicable to newly modified compounds. In contrast, Surface Plasmon Resonance (SPR) is sensitive label-free technology that detects molecular interactions measuring refractive index...
Aptamers have emerged as excellent molecular probes for cancer diagnosis and therapy. The aim of the current study was to determine feasibility using DNA aptamer cy-apt 20 developed by live cell-SELEX detecting targeting gastric cancer. specificity, sensitivity biostability in were assessed binding assay, cell fluorescence imaging, vivo tumor imaging animal model comparison with non-gastric cancers. Flow cytometric analysis showed that had higher than 78% maximal rate cells, much cells. Cell...
Abstract Programmed cell death-ligand 1 (PD-L1) has a significant role in tumor progression and metastasis, facilitating evasion from immune surveillance. PD-L1 can be detected the nucleus exert an oncogenic effect by nuclear translocation. Colorectal cancer (CRC) liver metastasis (CCLM) are among most lethal diseases worldwide, but mechanism of translocation CRC CCLM remains to fully understood. In this study, using CRISPR-Cas9-based genome-wide screening combined with RNA-seq, we found...
Two new Co(II) and Ni(II) complexes exhibiting DNA cytotoxic activities with 3-(2-pyridyl)pyrazole-based ligand, [Co(L)3](ClO4)2 (1) [Ni(L)3](ClO4)2 (2) (L=1-[3-(2-pyridyl)-pyrazol-1-ylmethyl]-naphthalene) were synthesized structurally characterized. Both 1 2 crystallized in the monoclinic system, space group P2(1)/c, for 1, a=12.8324(8), b=12.1205(8), c=33.27(2) Å, β=93.92(3)° Z=4; 2, a=12.8764(3), b=12.1015(3), c=33.2415(9) β=93.998(1)° Z=4. Among them, ions all coordinated by six N donors...
In our efforts to investigate the influence of intramolecular hydrogen bonding interactions and geometries pendant ligands on structures low-dimensional coordination architectures, two kinds have been selected: a) a chelating ligand, 3-(2-pyridyl)pyrazole (L1), with non-coordinated nitrogen atom as good acceptor b) three monocarboxylato different aromatic backbones (L2, L3 L4) , their MnII complexes, [Mn(L1)2(L2)2] (1), [Mn(L1)2(L3)2] (2) [Mn2(L1)2(L4)4] (3), prepared structurally...
The conformational ensembles of structured RNA's are crucial for biological function, but they remain difficult to elucidate experimentally. We demonstrate with HIV-1 TAR RNA that X-ray scattering interferometry (XSI) can be used determine ensembles. is based on site-specifically labeling pairs heavy atom probes, and precisely measuring the distribution inter-probe distances arise from a heterogeneous mixture solution structures. show XSI-based model ensemble closely resembles an independent...
RNA conformational transformations are integral to RNA's biological functions. Further, structured molecules exist as a series of dynamic intermediates in the course folding or complexation with proteins. Thus, an understanding and function will require deep incisive its behavior. However, existing tools investigate dynamics limited. Here, we introduce powerful fluorescence polarization anisotropy approach that utilizes rare base analogue retains substantial when incorporated into helices....
The DNA four-way (Holliday) junction is the central intermediate of genetic recombination, yet key aspects its conformational and thermodynamic properties remain unclear. While multiple experimental approaches have been used to characterize canonical X-shape conformers under specific ionic conditions, complete ensemble this motif, especially at low remains largely undetermined. In line with previous studies, our single-molecule Förster resonance energy transfer (smFRET) measurements dynamics...