Md. Rajdoula Rafe

ORCID: 0000-0003-4200-861X
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Research Areas
  • Natural Antidiabetic Agents Studies
  • Ethnobotanical and Medicinal Plants Studies
  • Phytochemicals and Medicinal Plants
  • Cancer therapeutics and mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • Diverse Scientific Research Studies
  • Essential Oils and Antimicrobial Activity
  • Seed and Plant Biochemistry
  • RNA Interference and Gene Delivery
  • Transcranial Magnetic Stimulation Studies
  • Genomics, phytochemicals, and oxidative stress
  • Phytochemistry and Bioactive Compounds
  • Nanoparticle-Based Drug Delivery
  • Advancements in Transdermal Drug Delivery
  • Liver Disease Diagnosis and Treatment
  • Antimicrobial agents and applications
  • Cancer Research and Treatment
  • Epilepsy research and treatment
  • Medicinal Plant Extracts Effects
  • Nanoplatforms for cancer theranostics
  • Neurological disorders and treatments
  • Ziziphus Jujuba Studies and Applications
  • Bacterial biofilms and quorum sensing
  • Lipid Membrane Structure and Behavior
  • Mosquito-borne diseases and control

Jagannath University
2019-2025

City University of Hong Kong
2023-2025

University of Dhaka
2018

Southeast University
2017

Background: Neurological disorders represent one of the most prominent causes morbidity and mortality that adversely affect lifestyle patients a major percentage these diseases exists in developing countries. Purpose: The objective this study was to examine prevalence prescription pattern for outpatients with neurological Bangladesh. Methods: conducted on 1,684 6 hospitals (National Institute Neurosciences Hospital, Dhaka Medical College Bangabandhu Sheikh Mujib University, Shaheed...

10.1159/000481812 article EN Annals of Neurosciences 2017-10-31

ABSTRACT Background and Aims The lack of therapeutic response characterizes treatment‐resistant depression despite undergoing at least two adequate monotherapy trials with medications from distinct pharmacologic classes. inability to attain remission in patients diagnosed major depressive disorder (MDD) is a significant issue concern within public health. Therefore, the management (TRD) poses obstacles for both healthcare professionals. Our goal was investigate published literature...

10.1002/hsr2.70370 article EN cc-by Health Science Reports 2025-01-01

Natural compounds have long been employed as medicines throughout the course of human history. Traditional medicine has and still uses natural materials, especially plant treatments, based on practical observations rather than pharmaceutical research. Ixora chinensis (Lam) several important medicinal properties which not studied extensively in Bangladesh. The present work carried out to evaluate diverse biological actions extract identification pure compounds. crude powder leaves barks was...

10.3329/bpj.v28i1.79443 article EN Bangladesh Pharmaceutical Journal 2025-01-30

Background: Oxidative stress is strongly linked in the development of numerous chronic and degenerative disorders. Medicinal plants with antioxidant anticholinesterase activities exert a key role for management oxidative related disorders mainly Alzheimer's disease (AD). Therefore purpose this study was to assess potentiality inhibitory activity crude methanolic extract (CME), petroleum ether fraction (PEF), chloroform (CLF), ethyl acetate (EAF) aqueous (AQF) Uvaria littoralis (U....

10.6000/2292-2598.2017.05.02.3 article EN Journal of Intellectual Disability - Diagnosis and Treatment 2017-07-19

Grewia asiatica (Family-Malvaceae), known as Phalsa in Bangladesh, is also native to India, Nepal, Pakistan, Cambodia and Thailand. The plant has a long history of traditional uses. present investigation was designed evaluate acute toxicity test, antidepressant sedative-hypnotic activities the methanolic extract leaves G. asiatica. In soluble fraction showed no significant changes body weight between control treated group at doses 1000, 2000 3000 mg/kg weight. could not significantly reduce...

10.3329/bpj.v22i2.42303 article EN Bangladesh Pharmaceutical Journal 2019-07-21

5-fluorouracil (5-FU) has been shown to have suffered from resistance which demands a solution entailing the development of 5-FU analogues. Our study aims design number analogues and evaluate their effectiveness against thymidylate synthase (TS) in silico compared parent with an effort obtain better hit(s). All molecules were optimized by molecular mechanics method utilizing MM2 forcefield parameters. Molecular docking these TS was performed catch on binding strength molecules, determination...

10.1016/j.heliyon.2020.e04978 article EN cc-by-nc-nd Heliyon 2020-09-01

Dendrophthoe falcata (Family Loranthaceae) is used extensively in rural area as a component of ethno-medicine for the treatment various diseases. In this study, crude extracts and fractions obtained from D. were investigated potential chemical constituents some biological activities. For medicinal properties antioxidant, brine shrimp lethality thrombolytic activities have been investigated. The structures isolated three compounds solved by extensive analyses their high resolution 1HNMR...

10.3329/dujps.v16i2.35259 article EN Dhaka University Journal of Pharmaceutical Sciences 2018-01-10

Abstract In this study, methanolic crude extracts of Stephania japonica (Thunb.) Miers. (MESJ) whole plants were examined for possible antidepressant and sedative-hypnotic activities. Herein, the forced swimming test tail suspension conducted to explore activity. addition, open field hole-board performed evaluate acute toxicity test, MESJ ensured safety up a dose 2000 mg/kg, p.o. The experimental doses 100 200 mg/kg both extract significantly (p<0.01 p<0.05) inhibited immobility time...

10.2478/cipms-2020-0010 article EN cc-by-nc-nd Current Issues in Pharmacy and Medical Sciences 2020-03-01

Cholinesterase inhibitors offer the possible pathway to fight against various types of neurodegenerative diseases. Grewia abutilifolia is used extensively in traditional and folk medicines mainly improve intellectual capabilities memory enhancement purposes which support its effects disorders. We performed preliminary phytochemical screening observe presence potential phytoconstituents G. leaf extracts evaluated acetylcholinesterase butyrylcholinesterase inhibitory properties measure...

10.3329/dujps.v17i1.37122 article EN Dhaka University Journal of Pharmaceutical Sciences 2018-06-24

Abstract Chikungunya virus is an Alphavirus that possesses characteristics similar to of arthropod-borne virus. has been one the major concerns for last few decades due its nature explosive spreading throughout world. This article intended give detailed information about virus, and includes pathogenesis, origins, diagnosis, treatment prevention. Although, recent researches suggests various approaches treating extensive literature search on revealed that, currently, there no effective...

10.2478/cipms-2019-0009 article EN cc-by-nc-nd Current Issues in Pharmacy and Medical Sciences 2019-03-01

Background Combretum indicum (locally known as Basantilata) is a notable medicinal plant belonging to the family Combretaceae. Extracts collected from leaves of this have activities including antibacterial, antipyretic, and antidiarrheal activities. Objective This study was designed evaluate crude methanolic leaf extract C. (MLCI) its in hyperglycemic dyslipidemic rats. Materials methods In-vivo antidiabetic antidyslipidemic were studied streptozotocin-induced diabetic rat models following...

10.4103/epj.epj_16_22 article EN Egyptian Pharmaceutical Journal 2022-07-01

Abstract: The article has been withdrawn from the journal Current Traditional Medicine. Bentham Science apologizes to readers of for any inconvenience this may have caused. Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php Disclaimer: It is a condition publication that manuscripts submitted not published and will simultaneously or elsewhere. Furthermore, data, illustration, structure table elsewhere must reported, copyright...

10.2174/2215083808666220504110815 article EN Current Traditional Medicine 2022-05-07
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