Metal complexes of antibiotics have shown promising antimicrobial activities against some resistant strain bacteria by inhibiting the growth or killing microorganisms. This phenomenon has lot impact when pathogenic microorganisms develop continuous resistance to available via various cellular defense mechanisms. Therefore, search for alternative drug-molecules is prime importance combat Antibiotic with metal ions attracted attention scientists looking new drugs and increase activity...

ABSTRACTThis study investigated the effects of presence a familiar pet dog on brain activity and psychophysiology in human volunteers. Fourteen participants (2 men, 12 women; mean age ± SD = 43.0 10.8 years) were enrolled study. Uptake 18F-2-fluoro-2-deoxyglucose ([18F]FDG) whole-brain positron emission tomography (PET) scans (but without interaction) absence their own was analyzed. In addition, an electrocardiograph recorded to assess heart rate variability. Psychological condition...

KOD Dash DNA polymerase can accept triphosphates of new deoxyuridine derivatives bearing a C5-substituent group via an α-methylene linker as substrate in the chain reaction (PCR) yielding corresponding functionalized effectively, while other conventional polymerases cannot tolerate modification substrate.

Gynura procumbens (Lour.) Merr. (Family: Asteraceae) is a tropical Asian medicinal plant found in Thailand, China, Malaysia, Indonesia, and Vietnam. It has long been utilized to treat variety of health concerns numerous countries around the world, such as renal discomfort, constipation, diabetes mellitus, rheumatism, hypertension. The chemical investigation resulted isolation characterization six compounds from methanol (MeOH) extract leaves procumbens, which were identified phytol (1),...

Abstract A thymidine analogue bearing a methyl ester at the C5 position was accepted as substrate by thermophilic family B DNA polymerases, KOD Dash, Pwo, and Vent(exo−), to form corresponding PCR product, but not Taq, Tth, T7 thermosequenase. Modified containing this prepared on large scale with Dash polymerase 5(methoxycarbonylmethyl)‐2′‐deoxyuridine 5′‐triphosphate substrate. The of modified further allowed react tris(2‐aminoethyl)amine or histamine an ester–amide exchange reaction...

The present study was designed to identify the endophytic fungi isolated from leaves of Trigonella foenum-graecum (local name: Fenugreek or Methi) Bangladesh, followed by a GC-MS analysis fungal culture filtrates explore major components in ethyl acetate extract and finally assess their putative antibacterial activity. Two pure extracts, entitled TFLE-1 TFLE-2 were leaf T. extraction with acetate. strains, identified as Fusarium lichenicola Trichoderma euskadiense respectively per...

The present article describes the isolation and characterization of secondary metabolites from leaves Cerbera odollam as well bioactivities crude methanolic extract its petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) aqueous (AQ) soluble fractions. In this investigation, successive chromatographic separation purification yielded β-amyrin (CO-01), lupeol (CO-02), β-sitostenone (CO-03) triticusterol (CO-04). study also indicated antioxidant, cytotoxic, antimicrobial, membrane...

Dendrophthoe falcata (Family Loranthaceae) is used extensively in rural area as a component of ethno-medicine for the treatment various diseases. In this study, crude extracts and fractions obtained from D. were investigated potential chemical constituents some biological activities. For medicinal properties antioxidant, brine shrimp lethality thrombolytic activities have been investigated. The structures isolated three compounds solved by extensive analyses their high resolution 1HNMR...

Dhaka Univ. J. Pharm. Sci. 6(1): 51-53, 2007 (June)
 
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The methanol extract (ME) of the powdered bark Glochidion multiloculare and its six vacuum liquid chromatographic (VLC) fractions (Fa-f) were investigated for antimicrobial, cytotoxic antioxidant activities. Only Fc Fd showed mild antimicrobial activity. Significant free radical (DPPH) scavenging activity was found in Ff (IC50 value = 9.27±0.117 ?g/ml). total phenolic content measured involving Folin-Ciocalteu reagent it highest fraction Fe (187.00±1.74 mg GAE/gm sample). Cytotoxicity (LC50)...

We synthesized various 5'-triphosphates of C5-substituted 2'-deoxyuridine derivatives bearing methylene linker at C5-alpha position. examined whether the (dUTP) can work as a substrate for modified DNA synthesis by PCR. found that only KOD dash polymerase, thermostable polymerase from extremely thermophilic archaeum, accepted substrates in place TTP PCR forming corresponding DNAs. On other hand, no could accept these analogues.

Litsea monopetala (Roxb.) Pers. (Family: Lauraceae) is a plant that holds substantial ethnobotanical significance due to its traditional and cultural importance. In this study, we conducted an extensive chemical investigation on L. monopetala, native the regions including Nepal, India, Bangladesh. Two unique secondary metabolites were isolated characterized from ethyl acetate (EtOAc) extract of leaves which identified as tri-trans poly-cis prenol-15 (1), acetylated derivative (2). The...

?-tocopherol (1), (2), polyprenol-12 (3), polyprenol-15 (4), stigmasterol and ?-sitosterol were isolated from the yellow flavicarpa variety of leaves Passiflora edulis. The structures compounds elucidated using 1H-NR 13C-NMR spectral analysis. organic aqueous soluble fractions crude methanolic extract evaluated for antioxidant, cytotoxic, thrombolytic antimicrobial activities. In DPPH free radical scavenging assay, fraction displayed maximum activity having IC50 value 139.56?g/ml. On other...

Six compounds, sitosta-4-en-3-one (1), 3β,28-dihydroxyolean-12-en (2), scandenone (3), alpinum isoflavone (4), stigmasterol (5) and lupeol (6) were isolated from the methanol soluble extract of stem bark Erythrina variegata. The structure compounds was established by extensive NMR studies as well co-TLC with authentic sample. petroleum ether, carbon tetrachloride, chloroform aqueous fractions methanolic variegata evaluated for antimicrobial, antioxidant thrombolytic properties. In...

According to WHO, cancer is one of the leading causes death worldwide, accounting for an estimated 9.6 million deaths in 2018. More significant improvements have been made management and treatment cancer, still there remains scope betterment procedures. Mostsynthetic anticancer drugs are known develop resistance, show cytotoxicity against normal cells due their non-selective nature, cause tremendous side effects. Medicinal plants significantly feasible sources organic compounds, better...