A5046393243- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Infant Development and Preterm Care
- Dermatology and Skin Diseases
- Genetic Mapping and Diversity in Plants and Animals
- Congenital Diaphragmatic Hernia Studies
- Genomics and Chromatin Dynamics
- Respiratory viral infections research
- Pediatric Pain Management Techniques
- Genomic variations and chromosomal abnormalities
- Data-Driven Disease Surveillance
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Food Allergy and Anaphylaxis Research
- Data Quality and Management
- Pharmaceutical studies and practices
- Neonatal and Maternal Infections
- Genetics and Neurodevelopmental Disorders
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Patient Safety and Medication Errors
- Genetic Neurodegenerative Diseases
- Census and Population Estimation
- Bioinformatics and Genomic Networks
- Anesthesia and Sedative Agents
Écologie Marine Tropicale des Océans Pacifique et Indien
2016-2024
Stallergenes Greer (France)
2008-2012
Université de Bourgogne
2008
Inserm
1996-2008
Maison des Sciences de l’Homme de Dijon
2004-2008
Laboratoire d'étude de l'apprentissage et du développement
2007
Institute for Medical Informatics and Biostatistics
2007
CHU Dijon Bourgogne
2004
Baylor College of Medicine
1995-1999
Nationwide Children's Hospital
1999
To determine the clinical, biochemical, and/or morphological features which could predict need for treatment of pseudocysts at diagnosis in a homogeneous population patients with alcoholic chronic pancreatitis.Between January 1983 and December 1993, all followed pancreatitis complicated by confirmed computed tomography (CT) scan were studied retrospectively. Two groups considered according to their pattern evolution therapeutic requirements. Group I included 45 that regressed spontaneously...
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by CTG expansion in the 3′ UTR of dystrophia myotonica protein kinase (DMPK) gene. It has been hypothesized that pathogenesis DM1 triggered toxic gain function expanded DMPK RNA. This RNA retained nuclear foci where it sequesters and induces alterations levels RNA-binding proteins (RNA-BP). To model study implication RNA-BP CUG-induced toxicity, we have generated Drosophila expressing non-coding mRNA containing 480...
Summary Few prospective population‐based studies of respiratory diseases have been conducted in term neonates. We aimed to describe mechanically ventilated disorders neonates and associated risk factors a regional‐based study livebirths between 37 41 weeks. The was for epidemiological data recording, retrospective collecting additional from charts with severe (mechanically ventilated) disorders. A total 14 813 gestational age (GA) 37–38 weeks 50 187 GA 39–41 were included. overall incidences...
A candidate gene, myotubularin, involved in the pathogenesis of X-linked myotubular myopathy (MTM1) was isolated recently. Mutations originally were identified 12% patients examined for 40% coding sequence, raising possibility that additional genes could be responsible a proportion cases. We report here identification mutations 26 41 independent male with muscle biopsy-proven MTM, by direct genomic sequencing 92% known sequence myotubularin gene. Eighteen had point mutations, including one...
Tests of 29 human variable number tandem repeat probes in inbred mouse lines showed that 80% (23/29) cross-hybridize, and 48% (14/29) produce multiple band, minisatellite polymorphisms (fingerprint patterns). Mini-satellite-type detected by 11 were characterized eight different strains; on average, 240 polymorphic differences between pairs strains. Reproducible fingerprint patterns permit the study segregation experimentally designed crosses. As an example, we constructed primary genetic...
Differences between major allergens from distinct grass species remain to be investigated, both in terms of structure and antigenicity.Group 1 5 purified five common Pooideae were analysed by mass spectrometry (MS). Major histocompatibility complex (MHC) class II-restricted T cell epitopes identified using predictive algorithms human leucocyte antigen (HLA)-binding assays. CD4+ reactivity IgE binding assessed based on the induction CD154 expression peripheral blood mononuclear cells...
The nonobese diabetic (NOD) mouse is a widely used model for genetic studies of insulin-dependent diabetes mellitus due to the similarities between murine and human diseases. To aid in localization identification diabetes-related susceptibility genes, we have constructed an interspecific backcross NOD Mus spretus (SEG/Pas) mice. Although no animals were observed first generation (SEG/Pas x NOD) (BC1), incidence insulitis (lymphocyte infiltration islets Langerhans) exceeded 20% after...
Background It is currently recognized that an optimized nutritional approach, consisting of early and substantial supply protein energy by parenteral route, may be beneficial for very low birth weight infants recent guidelines endorse this strategy. However, the impact enhanced nutrition (PN) on acid-basic balance has never been investigated. The aim present study to assess effect nutrient intake acid-base homeostasis in a large population preterm PN. Methods This observational described...
Objectives The primary objective of this study is to determine the current level patient medication exposure in Level 3 Neonatal Wards (L3NW). secondary evaluate first month life rate prescription not cited Summary Product Characteristics (SmPC). A database containing all prescriptions collected as part a benchmarking program L3NW. Material and methods research two-year observational cohort (2017–2018) with retrospective analysis medications prescribed 29 French Seventeen L3NW are present...
The present study was designed to determine the efficacy of administration palivizumab preterm infants with gestational age (GA) < or = 30 weeks without bronchopulmonary dysplasia (BPD). All patients born GA BPD on Day 28 and hospitalized for RSV bronchiolitis in Burgundy (12 hospitals) from December 1 April next year were included this prospective observational during five successive seasons (1999-2000, 2000-2001, 2001-2002, 2002-2003, 2003-2004). Palivizumab given premature a 2002-2003...
What is known The neonatal intensive care units (NICUs) are at the highest risk of drug dose error all hospital wards. NICUs also have most complicated prescription modalities. computerization process currently recommended to decrease preventable adverse effects (pADEs) in NICUs. However, Computer Prescribing Order Entry–Clinical Decision Support (C.P.O.E./C.D.S.) systems been poorly studied NICUs, and their technical compatibility with specificities has limited. Objectives We set up a...
Background: The efficacy of palivizumab prophylaxis after bronchopulmonary dysplasia (BPD) has been demonstrated in a single placebo-controlled trial. Concern emerged about the degree palivizumab. This study was designed to determine administration premature infants with gestational age ≤32 weeks, past history BPD and younger than 6 months at start epidemic. Methods: Prospective observational respiratory syncytial virus (RSV) bronchiolitis requiring hospitalization Burgundy (12 hospitals)...
The extensive use of broad-spectrum antibiotics has been associated with major changes in the spectrum organisms involved early-onset neonatal infection (EONI), their susceptibility to antibiotics, or both. Therefore, guidelines for a more rational neonates have developed. We conducted population-based observational study assess effectiveness and compliance restrictive antibiotic therapy EONI.Neonates receiving within 72 hours life were identified prospectively by surveillance 18 hospitals...
Background: Postnatal corticosteroids (PC) are widely used in very preterm infants. International reports and national multicenter trials describe a marked variability across countries inter-sites, the use of PC. Few information is available on therapeutic indications prescription characteristics Aim: The main objective this study was to exposure PC large cohort infants born at less than 32 weeks gestation, according data 41 tertiary-care NICUs France. Secondary objectives were indications,...
Abstract Aims Gastro‐oesophageal reflux is common in newborns, especially premature infants. Treatment by medication controversial as the drugs prescribed have not been consistently proven to be effective and are known adverse effects. This study sought identify trends prescription of anti‐reflux a large group French neonatal units. Methods Data on prescriptions treatments—proton pump inhibitors (PPIs), antacids, histamine‐2 receptor antagonists (H2RAs), prokinetics—from 2014 2022 for...
To assess the Burgundy perinatal network (18 obstetrical units; 18 500 births per year), discharge abstracts and additional data were collected for all mothers newborns. In accordance with French law, rendered anonymous before statistical analysis, linked to patients using a specific procedure. This procedure allowed concerning each mother be those her newborn(s). study showed that newborns included in regional database; their infant(s) cases. Additional (gestational age) obtained 99.9% of
Introduction: Prescribing antibiotics to newborns is challenging, as excess are a risk factor for increased morbidity and mortality. The objective of this study was describe the evolution antibiotic exposure over three years in large network level 3 neonatal wards where each center informed yearly its own results other centers has full autonomy improve performance. Patients Methods: This prospective, observational prescriptions 2017–2019 period 23 French wards. relied on an internal...