A5028902673- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Aortic Disease and Treatment Approaches
- Monoclonal and Polyclonal Antibodies Research
- Inflammasome and immune disorders
- Circadian rhythm and melatonin
- Rabies epidemiology and control
- Cell Adhesion Molecules Research
- Cytomegalovirus and herpesvirus research
- Connective tissue disorders research
- Identification and Quantification in Food
- Medical Image Segmentation Techniques
- Advanced Neural Network Applications
- Trace Elements in Health
- Infectious Diseases and Tuberculosis
- Cardiac Valve Diseases and Treatments
- Nuclear Receptors and Signaling
- Erythrocyte Function and Pathophysiology
- Genetic diversity and population structure
- Peripheral Neuropathies and Disorders
- Caveolin-1 and cellular processes
- Microbial infections and disease research
- Metabolism and Genetic Disorders
- Signaling Pathways in Disease
- Macrophage Migration Inhibitory Factor
Nanjing Normal University
2024
Tianjin Medical University
2024
Tianjin Chest Hospital
2020-2023
Tianjin University
2023
Nanjing University
2006
Kanazawa University
2000-2002
Australian Government
2000
University of Technology Sydney
1995-1997
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanisms, play an essential role in occurrence progression AS. The human pineal gland primarily produces melatonin (MT), indoleamine hormone powerful anti-oxidative, anti-pyroptotic, anti-apoptotic properties. This study examined MT's anti-oxidative stress anti-pyroptotic effects on THP-1...
The technique of Random Amplified Polymorphic DNA (RAPD) PCR has been used to detect polymorphisms among Toxoplasma gondii strains. Seven arbitrary oligonucleotides (10-mer) were as primers amplify total genomic DNAs and significant genetic heterogeneity was detected 11 T. strains with different virulence for mice. observed allowed relationship dendrograms be constructed by PHYLIP PAUP analyses. relationships the generated 2 analyses using completely assumptions similar. Both revealed groups...
Histone deacetylase enzymes (HDACs) regulate protein acetylation. HDAC1 is known to enhance ischemia/reperfusion (I/R) injury, but its underlying mechanism(s) of action have not been defined. Here, in vivo mouse models myocardial I/R were used investigate the role during injury. We show that enhances inflammatory responses mice. Using a constructed macrophage H/R (hypoxia/ regeneration) injury model (Raw264.7 cells), we identified Nur77 as target macrophages. deficient macrophages failed...
Postoperative acute kidney injury (AKI) occurs in 20-40% of type A aortic dissection (ATAAD) patients undergoing cardiac surgery. predictive model could be developed to assess the probability AKI with ATAAD before and after surgery a timely manner.This retrospective study enrolled total 224 ATAAD. Patients were subjected arch replacement using tetrafurcate graft stented elephant trunk implantation according Sun's procedure. Statistical comparison for collected data was done Student's t test...
Vascular endothelium has attracted extensive attention due to its important role in many physiological and pathological processes. Many methods have been developed study the components their functions vascular endothelium. Here we report a novel approach investigate using normal rat lungs as model. We perfused lung beds with sulfosuccinimidyl-6-(biotinamido) hexanoate, biotin analog, label endothelial membrane proteins. The biotinylated proteins were isolated from homogenate immobilized...
Aortic stenosis is a common heart valvular disease whose pathological processes include an inflammatory reaction and lipid accumulation. However, its detailed pathogenesis yet to be completely elucidated. Therefore, it of great significance further explore the molecular mechanisms aortic stenosis. Four datasets were downloaded from Gene Expression Omnibus (GEO) database. Firstly, differently expressed genes (DEGs) screened between control samples. Secondly, weighted gene co-expression...
Abstract Background Investigating the unexplored territory of lncRNA m6A modification in colorectal cancer (CRC) vasculature, this study focuses on LINC01106 and YTHDF1. Methods Clinical assessments reveal upregulated promoting vascular generation via miR-449b-5p-VEGFA pathway. Results YTHDF1, elevated CRC tissues, emerges as an adverse prognostic factor. Functional experiments showcase YTHDF1’s inhibitory effects cell dynamics. Mechanistically, Me-CLIP identifies m6A-modified LINC01106,...
Gullain-Barré syndrome (GBS) is a rare autoimmune condition primarily presenting with symmetrical progressive limb weakness. It frequently associated sensory and autonomic symptoms disturbances often manifests seropositivity for anti-ganglioside antibodies. Infections are considered major precipitants; however, GBS post-craniotomy severe traumatic brain injury rarity. A 79-year-old female underwent craniotomy cerebellar contusion sustained from injury, leading to quadriplegia, dysfunction,...
In the present study, we perfused rhesus lung vascular bed in situ with sulfo-NHS-LC-Biotin to biotinylate its luminal surface membrane proteins. After homogenization, dialysis, and affinity chromatography, biotinylated endothelial proteins were successfully isolated characterized as enriched no contamination of intracellular When they used immunogens develop monoclonal antibodies (MAbs), three MAbs—TX111, TX112, TX113—were obtained. Among them, TX111 was demonstrated specifically bind...
As an important pre-processing step in clinical applications, automatic and accurate 3D cardiovascular image segmentation has attracted more attention. However, structures are often with high diversity, blood pool myocardium shapes also large variability, ambiguous cardiac borders make the task very challenging. In this paper, a novel deep neural network to segment from three dimensional images is introduced by fully exploiting global context complementary information encoded different...
Abstract Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanisms, play an essential role in occurrence progression AS. The human pineal gland primary producer melatonin (MT), indoleamine hormone powerful anti-oxidative, anti-pyroptosis, anti-apoptotic properties. This study examined MT's antioxidative stress anti-pyroptotic effects on THP-1...
Abstract-Alpha-fetoprotein (AFP) is a major serum protein (Mr, =70,000) synthesized during fetal life. Reappearance of AFP in adult often signals pathological conditions, particularly hepatocarcinomas and teratocarcinomas. To obtain monoclonal antibodies against for further study the structure biological function AFP, novel method making hybridoma cell lines producing by immunization animals with synthetic peptides were proposed. One epitope peptide was based on bioinformatics analysis...