A5033829782- Phytochemistry and Biological Activities
- Synthetic Organic Chemistry Methods
- Biological Activity of Diterpenoids and Biflavonoids
- Marine Sponges and Natural Products
- Advanced Synthetic Organic Chemistry
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactivity Studies
- Sesquiterpenes and Asteraceae Studies
- Medicinal plant effects and applications
- Plant biochemistry and biosynthesis
- Nanofabrication and Lithography Techniques
- Chemical Synthesis and Analysis
- Cancer Treatment and Pharmacology
- Plant-based Medicinal Research
- HER2/EGFR in Cancer Research
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Monoclonal and Polyclonal Antibodies Research
Universidad de Salamanca
2008-2017
University College London
2013
In this communication we describe a novel acid-cleavable linker strategy for antibody–drug conjugation. Functional disulfide bridging of the single interchain bond trastuzumab Fab fragment yields homogeneous conjugate bearing thiomaleamic acid linker. This is stable at physiological pH and temperature, but quantitatively cleaves lysosomal to release drug payload.
Bromomaleimides are useful building blocks in synthesis and powerful reagents for the selective chemical modification of proteins. A mild new these is described, along with convenient transferability approach to dithiomaleimides bromopyridazinediones.
In this review, the natural source, structure, biological activities and synthesis of labdanes diterpenes with highly functionalized B rings, described to date are shown. The structures for these compounds have been classified taking into account number oxygenated positions ring. manner classification has 7 groups deoxygenated labdanes, 6 trioxygenated one group tetraoxygenated ones. Keywords: Bioactivities, diterpenes, forskolin, synthesis, terpenes, B-rings, adenylate cyclase, nitric...
A new access to tricyclic diterpenes of podocarpane skeleton has been opened, in excellent overall yields, and an efficient synthesis (+)-nimbiol from sclareol achieved.
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Sclareol has been employed as starting material for the synthesis of several advanced intermediates towards highly ring B oxygenated labdanes. Dinorlabdanes 6,7,8,9-tetraoxygenated with 6,7-dioxygenated functionalities a-cis or O-cis dispositions, have prepared and can be used forskolin analogues synthesis.