A5038655862- Nuclear Receptors and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Macrophage Migration Inhibitory Factor
- Apelin-related biomedical research
- Neurological disorders and treatments
- Retinoids in leukemia and cellular processes
- Nerve injury and regeneration
- RNA regulation and disease
- Estrogen and related hormone effects
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Photochromic and Fluorescence Chemistry
- Zebrafish Biomedical Research Applications
- Regulation of Appetite and Obesity
- Neuropeptides and Animal Physiology
- Spinal Cord Injury Research
- Nitric Oxide and Endothelin Effects
- Neural and Behavioral Psychology Studies
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
Université Laval
2008-2023
Centre hospitalier universitaire de Québec
1998-2023
Centre hospitalier de l'Université Laval
1997-2018
Wilfrid Laurier University
1999-2009
Ludwig Cancer Research
2009
Hôpital de l'Enfant-Jésus
1996
Wayne State University
1990
Sinai Hospital
1990
Transcription factors involved in the specification and differentiation of neurons often continue to be expressed adult brain, but remarkably little is known about their late functions. Nurr1, one such transcription factor, essential for early midbrain dopamine (mDA) continues into adulthood. In Parkinson's disease, Nurr1 expression diminished mutations gene have been identified rare cases disease; however, significance these observations remains unclear. Here, a mouse strain conditional...
We investigated the dopaminergic (DA) neuronal degeneration in animals subjected to systemic treatment of rotenone via subcutaneous delivery. Behavioral observations revealed a hypokinetic period rats sacrificed at 3 and 5 days, dystonic episodes 8 days. Less than 20% total number given depicted brain lesions after days treatment, as demonstrated by significant loss DA fibers striatum, but not nigral neurons. Tyrosine hydroxylase-negative striatal territories were characterized post-synaptic...
Abstract Animal models are invaluable tools to study neurodegenerative disorders but a general consensus on the most accurate rodent model of Parkinson’s disease has not been reached. Here, we examined how different methods MPTP administration influence degeneration dopaminergic (DA) system. Adult male C57BL/6 mice were treated with same cumulative dose following four distinct procedures: (i) subacute i.p. injections; (ii) 28‐day chronic s.c. infusion; (iii) and (iv) 14‐day infusion....
The energetic costs of behavioral chronic stress are unlikely to be sustainable without neuronal plasticity. Mitochondria have the capacity handle synaptic activity up a limit before depletion occurs. Protective mechanisms driven by induction genes likely evolved buffer consequences on excitatory neurons in prefrontal cortex (PFC), as this circuitry is vulnerable excitotoxic insults. Little known about involved mitochondrial adaptation buildup stress. Using combinations genetic manipulations...
The serotoninergic (5-HT) input from the dorsal raphe nucleus (DRN) to midbrain dopamine (DA) neurons is one of most prominent. In this study, using standard extracellular single cell recording techniques we investigated effects electrical stimulation DRN on spontaneous activity substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) DA in anesthetized rats. Poststimulus time histograms (PSTH) revealed two different types response both SNpc VTA. Some cells exhibited an...
Abstract Objective The objective of the present study was to investigate effect docosahexaenoic acid (DHA), a polyunsaturated fatty (omega‐3), on levodopa‐induced dyskinesias (LIDs) in parkinsonian 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)–treated monkeys. Methods We explored DHA two paradigms. First, group MPTP monkeys primed with levodopa for several months before introducing DHA. A second (de novo) exposed therapy. Results administration reduced LIDs both paradigms without...
Abstract Growing evidence from in vitro studies suggests that spinal serotonin (5‐HT) receptor subtypes 5‐HTR 1A and 7 are associated with an induction of central pattern generator activity. However, the possibility a specific role for these locomotor rhythmogenesis vivo remains unclear. Here, we studied effects single dose (1 mg/kg, i.p.) 8‐hydroxy‐2‐(di‐N‐propylamino)‐tetralin (8‐OH‐DPAT), potent selective 1A/7 agonist, mice cord transected at low‐thoracic level (Th9/10). The results show...
Abstract: This study was designed to investigate the possible involvement of members nuclear receptor family transcription factors in effects antipsychotic drugs used treatment schizophrenia. We have identified, using RT‐PCR screening, an important modulation nerve growth factor‐inducible B (NGFI‐B) mRNA levels by typical and atypical neuroleptics rat forebrain. NGFI‐B, a member family, can be observed target structures dopaminergic pathways. Using situ hybridization, we also demonstrate...
A role of serotonin receptors (5-HTRs) in spinal rhythmogenesis has been proposed several years ago based mainly upon data showing that bath-applied 5-HT could elicit locomotor-like rhythms vitro isolated cord preparations. Such a was partially confirmed vivo after revealing systemically administered 5-HTR(2) agonists, such as quipazine, induce some movements (LM) completely cord-transected (Tx) rodents. However, given the limited binding selectivity currently available it remained difficult...
Monitoring gene expression has been intensively used to identify neurobiological and neuroanatomical substrates associated with administration of antipsychotic drugs. Transcription factors the <i>Nur</i> family (<i>Nurr1</i>, <i>Nur77</i>, <i>Nor</i>-1) are orphan nuclear receptors that have recently dopamine neurotransmission. <i>Nurr1</i> is involved in midbrain neuron development. <i>Nur77</i> <i>Nor</i>-1 expressed dopaminoceptive areas such as striatum, nucleus accumbens, prefrontal...
J. Neurochem. (2010) 114 , 1651–1658. Abstract Cystamine has shown significant neuroprotective properties in preclinical studies of Parkinson’s disease (PD) and Huntington’s (HD). Cysteamine, its FDA‐approved reduced form, is scheduled to be tested for clinical efficacy HD patients. Here, we studied the key cystamine metabolites, namely cysteamine, hypotaurine taurine, as well cysteine, order identify which one more distinctively responsible action cystamine. After a single administration...