A5100664570- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Lipid metabolism and biosynthesis
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Breast Cancer Treatment Studies
- Renal Diseases and Glomerulopathies
- Cancer Mechanisms and Therapy
- Medicinal Plant Pharmacodynamics Research
- Bladder and Urothelial Cancer Treatments
- Chronic Kidney Disease and Diabetes
- Galectins and Cancer Biology
- Hippo pathway signaling and YAP/TAZ
- Cervical and Thoracic Myelopathy
- Folate and B Vitamins Research
- Traditional Chinese Medicine Studies
- Intraocular Surgery and Lenses
- PI3K/AKT/mTOR signaling in cancer
- Traumatic Ocular and Foreign Body Injuries
- Orthopedic Surgery and Rehabilitation
- Facial Trauma and Fracture Management
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Biomarkers in Disease Mechanisms
- Multiple Myeloma Research and Treatments
Second Xiangya Hospital of Central South University
2024
Zhejiang Chinese Medical University
2009-2024
Shangluo Central Hospital
2024
Central South University
2024
Affiliated Hospital of Zunyi Medical College
2009
Zigong First People's Hospital
2005
Weifang People's Hospital
2005
Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC). OTU deubiquitinase 5 (OTUD5), a DUB family member, has been recognized as critical regulator bladder cancer, breast cancer HCC. However, expression biological function OTUD5 HCC are still controversial.
ω-3 polyunsaturated fatty acids (n-3 PUFA), in particular the marine-derived forms eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), have been demonstrated to affect cancer cell replication, cycle death. Epidemiological studies also suggested diets rich n-3 PUFA were inversely correlated with development of cancer. In present study, we explored effects DHA EPA on proliferation activity apoptosis human lung adenocarcinoma line A549. A methyl thiazolyl tetrazolium (MTT) assay was used...
The present study identified that ω‑3 long chain polyunsaturated fatty acids (ω‑3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) demonstrate anti‑proliferative effects in lung cancer A549 cells. MTS cytotoxicity assays were conducted to confirm PUFAs induced cell death. Autophagy‑associated gene signaling pathways also detected. Microtubule‑associated protein light 3 (LC3) expression was found be increased subsequent treatment with DHA EPA, the of LC3‑II particularly...
Objectives. This study is aimed at investigating the anticancer activity of Fuzheng Jiedu decoction (FJD) alone or in combination with cisplatin ovarian cancer (OC) models, as well its underlying mechanisms action. Methods. The activities FJD, cisplatin, and PI3K inhibitor (LY294002, LY) activator (IGF-1) were evaluated OC cell lines vitro a SKOV3 xenograft mouse model vivo. proliferation invasion ability measured using MTT, EdU, transwell assays, respectively. apoptosis was examined by flow...
Purpose Aromatase, encoded by the CYP19 gene, catalyzes final step of conversion androgens to estrogens. Given critical role in estrogen synthesis, potential influence rs4646 polymorphism on breast cancer survival, deserves further study. Methods Genotyping for variants was performed 406 Chinese women with stage I–II and operable III cancer. Associations were evaluated between genotypes disease-free survival (DFS). Results In premenopausal patients, who are homozygous minor allele (AA) have...
Background Previous observational studies have indicated a potential association between metabolic syndrome (MetS) and asthma, though the causal nature of this connection is still uncertain. Our study used Mendelian randomization (MR) to examine relationship its components with asthma.
Background/Aims: Neoantigens are peptides produced by translation of mutant exons and existed in tumor tissues instead normal tissues, thus, we desired to investigate the antigenic peptide epitopes cancerspecific neoantigen, detect affinity nonapeptide with corresponding Human Leukocyte Antigen I (HLA I) allele molecule, order understand relationship exon genes Colorectal Cancer (CRC) patients drive that currently known for tumorigenesis CRC. Methods: The next generation sequencing (NGS)...
e11516 Background: Polymorphisms in the aromatase CYP19A1 gene have been shown to alter activity as well circulating steroid hormone levels postmenopausal women. The aim was verify potential association between genetic polymorphisms and clinical outcome of therapy receptor (HR) - positive early breast cancer. Methods: Genotyping for rs4646 (C/A) polymorphism performed on 287 Chinese women with HR-positive cancer Zhejiang Cancer Hospital. Associations were evaluated genotypes disease-free...
Carbonyl reductase 1 (CBR1) is theorized to participate in various cellular processes, such as signal transduction, apoptosis, carcinogenesis and drug resistance, highly expressed certain malignancies, including lung tumors. Several studies have provided evidence that gene polymorphisms may affect susceptibility non-small cell cancer (NSCLC). The present study aimed investigate the association between CBR1 single-nucleotide (SNPs) rs3787728 rs2835267, NSCLC a Chinese population. data...
Two-stage image inpainting method based on transformer and Fast Fourier convolution