A5025681540- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Automotive and Human Injury Biomechanics
- Sarcoidosis and Beryllium Toxicity Research
- Long-Term Effects of COVID-19
- Medical Imaging and Pathology Studies
- Transplantation: Methods and Outcomes
- Elasticity and Material Modeling
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- SARS-CoV-2 and COVID-19 Research
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Inflammasome and immune disorders
- Ultrasound in Clinical Applications
- Advanced Neuroimaging Techniques and Applications
- Heat Transfer Mechanisms
- Traumatic Ocular and Foreign Body Injuries
- Heat Transfer and Boiling Studies
- Organ Transplantation Techniques and Outcomes
- Infection Control and Ventilation
- Vasculitis and related conditions
- Occupational and environmental lung diseases
- Fungal Infections and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
Cleveland Clinic
2011-2023
National Heart Lung and Blood Institute
2023
All India Institute of Medical Sciences
2021-2023
Creative Commons
2023
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2021
Cleveland Clinic Lerner College of Medicine
2020
Case Western Reserve University
2020
Cleveland Institute of Music
2019
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2015-2017
Leflunomide has been reported as an alternative therapy in sarcoidosis. However, the published data are limited. We performed a retrospective chart review of tolerance and effects leflunomide patients with 76 were included. The most common reasons for initiation progression disease or failure other immunomodulator therapy. Side-effects attributable to noted 34% subjects, prompting discontinuation 17%. lungs target 33 (44%) extrapulmonary organs 45 (59%). mean ± sd change forced vital...
In patients with COVID-19, granulocyte-macrophage colony stimulating factor (GM-CSF) might be a mediator of the hyperactive inflammatory response associated respiratory failure and death. We aimed to evaluate whether mavrilimumab, monoclonal antibody GM-CSF receptor, would improve outcomes in COVID-19 pneumonia systemic hyperinflammation.This investigator-initiated, multicentre, double-blind, randomised trial was done at seven hospitals USA. Inclusion required hospitalisation, pneumonia,...
In patients with Covid-19, myocardial injury and increased inflammation are associated morbidity mortality. We designed a proof-of-concept randomized controlled trial to evaluate whether treatment canakinumab prevents progressive respiratory failure worsening cardiac dysfunction in SARS-CoV2 infection, injury, high levels of inflammation.The primary hypothesis is that canakiumab will shorten time recovery.The three C study (canakinumab Covid-19 Cardiac Injury, NCT04365153) double-blind,...
Introduction- DKA was formerly considered a hallmark of type 1 DM, but it also occurs in individuals with 2 DM who can sometimes subsequently be treated oral glucose-lowering agents. Performing VBG rather than an ABG is particularly convenient the ICU and emergency department, either peripherally or from central venous line which blood quickly drawn. Aims- The main aim study is- To arterial gas parameters its correlation complications treatment outcome patients ketoacidosis cases diabetes....
Sarcoidosis is reported to recur after lung transplantation (LT). We sought determine the frequency of recurrent disease LT and predictors recurrence. also evaluated incidence severity acute cellular rejection (ACR) episodes among these patients.The database patients at Cleveland Clinic was interrogated for sarcoidosis who underwent between May 1993 2011. Charts were reviewed demographics, type transplant, posttransplant biopsy findings, outcomes.Data available 30 (mean age, 50 ± 9.3 years;...
In this article, we describe a hybrid optimizer based on highly accurate response surface method, which uses several radial basis functions and polynomials as interpolants. The is capable to interpolate linear well non-linear in multi-dimensional spaces having up 500 dimensions. accuracy, robustness, efficiency, transparency conceptual simplicity are discussed. Based the extensive testing performed 296 test functions, (RBFs) approach seems computationally easy implement results superior,...
Long-term treatment of pulmonary sarcoidosis with glucocorticoids has been associated toxicity and other adverse events, highlighting the need for alternative therapies. The goal this study was to evaluate efficacy safety repository corticotropin injection (RCI, Acthar® Gel) in patients validate endpoints use future clinical trials.In multicenter, randomized, placebo-controlled trial, subjects received subcutaneous RCI (80 U) twice weekly or matching placebo through 24 weeks a double-blind...
For the majority of apparently healthy adults, mask wearing while at rest or during activities daily living is recommended to be safe and effective for reducing risk person-to-person airborne transmission SARS-Cov-2.1,2 Original research has yet find evidence showing an effect on clinical indicators exercise safety.3 In this study, we tested whether stress testing (EST) peak exhaustion provokes clinically indicated safety concerns.
<b>Background:</b> Silicosis is an ancient occupational illness reported in silica mill workers, agate stone slate pen workers and mining industry. However its association flour has not been established. <b>Aims:</b> To study the incidence of silicosis respiratory morbidity workers. <b>Settings Design:</b> A prospective 56 working with open grinding stones was undertaken. <b>Materials Methods:</b> who volunteered following information regarding purpose were recruited from community. Detailed...
ABSTRACT A genetic algorithms-based multiobjective optimization study has been carried out for the bottom gas injection process practiced in steelmaking vessels. Two objective functions, one dealing with efficacy of mixing and second characterizing stress level at ladle walls, have evaluated from a numerical solution coupled Reynolds averaged transient Navier-Stokes equations, energy species conservation as well governing equations turbulent kinetic its dissipation rate. Pareto front...