OBJECTIVE: Antidepressants that increase serotonin or norepinephrine in the brain are effective treating depression, but there is no neuropsychological account of how these changes relieve depressive states. Cognitive theories suggest biases information processing lead depressed patients to make unrealistically negative judgments about themselves and world. METHOD: A single dose noradrenergic antidepressant reboxetine placebo was administered 24 healthy volunteers. Effects on emotional were...

The metastasis along peritoneal surfaces of serous cystadenocarcinoma, the most common ovarian malignancy, occurs early and is present in patients at time clinical diagnosis. In many patients, however, computed tomography (CT) unable to demonstrate metastases because their small size similarly has been normal sized lymph nodes. Serous cystadenocarcinoma contains histologic calcification approximately 30% cases; thus, CT scans were retrospectively reviewed 15 with pathologically proved stage...

Background: The degree to which psychiatric patients want play a role in decision making and their desire for information regarding treatment has not been studied detail.Aims: To measure the seeking decision-making preferences of patients.Method: Autonomy Preference Index (API) was adapted use psychiatry administered community mental health team (CMHT) user groups.Results: Desire illness very high. There great variation extent wanted make decisions care. greater young those...

Bluebird House is the only mixed gender NHS secure forensic psychiatric hospital for adolescents in South of England. It has admitted more than 30 female patients since service opened 2008. The admission criteria are that must be detained under Mental Health Act and present evidence being a risk harm to others. This article describes clinical characteristics consecutive highly specialised adolescent inpatient service. Key results include very high rate incidents behaviours exhibited by...

This paper examines the characteristics of a group 64 young men, who were consecutively admitted to Bluebird House, an NHS mixed gender, adolescent forensic, medium secure hospital. The examined focus on men's clinical presentations, as informed by Millon Adolescent Clinical Inventory, and their ICD10 (WHO 1992) diagnoses. also males' route into, out of, well risk profiles, especially with regards others, Structured Assessment Violence Risk in Youth findings staff recorded incidents....

There has been increased research in recent years on incidents within adolescent inpatient psychiatric units, although findings to date have somewhat inconsistent. We analysed all reported by 37 consecutively discharged patients from a mixed sex forensic hospital. Findings include very high overall rate of incidents. A small number female with emerging emotionally unstable personality disorder accounted for the majority violent and other Almost assaulted someone during their admission....

Bluebird House is a mixed-gender adolescent medium-secure forensic unit. There paucity of data available about this unique patient group. We aimed to explore the demographic, clinical and personality characteristics first 100 patients admitted used retrospective cross-sectional study consecutive House. Demographic were collected from medical notes including Millon Adolescent Clinical Inventory. The young people an unit have had very high incident rates, particularly amongst females. Incident...

Objective measures of canine gait quality via force plates, pressure mats or kinematic analysis are considered superior to subjective assessment (SGA). Despite research demonstrating that SGA does not accurately detect subtle lameness, it remains the most commonly performed diagnostic test for detecting lameness in dogs. This is largely because financial, temporal and spatial requirements existing objective equipment makes this technology impractical use general practice. The utility slow...

Abstract Looping Star is a near‐silent, multi‐echo, 3D functional magnetic resonance imaging (fMRI) technique. It reduces acoustic noise by at least 25dBA, with respect to gradient‐recalled echo echo‐planar (GRE‐EPI)‐based fMRI. has successfully demonstrated sensitivity the cerebral blood‐oxygen‐level‐dependent (BOLD) response during block design paradigms but not been applied event‐related auditory perception tasks. Demonstrating Star's such tasks could (a) provide new insights into...

Abstract Aberrant responses within homeostatic, hedonic and cognitive systems contribute to poor appetite control in those with an overweight phenotype. The system incorporates limbic meso‐limbic regions involved learning reward processing, as well cortical motivation, decision making gustatory processing. Equally important this complex, multifaceted framework are the inhibitory valuation of food choices. Regions these display insulin receptors pharmacologically increasing central...

We investigated the effect of a single oral dose selective noradrenaline reuptake inhibitor, reboxetine (4 mg), on plasma and salivary cortisol in 24 healthy volunteers randomized, placebo-controlled, parallel-group design. Reboxetine significantly increased both cortisol, although correlation between responses saliva was modest. Our results are consistent with previous neuroendocrine challenge studies showing that potentiation brain function stimulates hypothalamic-pituitary-adrenal axis....

Clozapine has been used to good effect in the treatment of adults with borderline personality disorder, but there is scant evidence it being an adolescent population these difficulties.Clozapine was trialled a clinical presentation consistent emerging disorder.There large reduction number incidents involving abuse staff, or harm self, 8 weeks after commencing clozapine therapy, compared prior, and also episodes use seclusion 13 prior. The young person able be reintegrated ward environment...

We aimed to survey the knowledge of psychiatrists on assessment decision-making capacity. Ninety-two all grades and three other doctors attending a regional conference were marked their verbal response question ‘What are key elements in patient's capacity?’ On average, participants mentioned out five testing Scores negatively correlated with age (Pearson's coefficient 0.275, sig 0.007). Section 12 status grade had no impact knowledge. Most have reasonable assessing Over third two or fewer...

This paper uses data produced by the Ministry of Justice to look for trends in numbers various categories patients detained under Mental Health Act England and Wales between 2003 2016. Specifically, we have focussed on with restrictions place. The number 'restricted' patients, who are largely secure psychiatric hospitals, has risen substantially during this period. If trend continues, there will be need further expansion beds years ahead. Factors driving increased restricted discussed paper.

Background: Psychotropic medication is widely prescribed for patients with emotionally unstable personality disorder, despite a limited evidence base. In adults, clozapine has been shown to demonstrate reduction in the incidents of aggression and subsequent restraints. This study seeks examine effect on overall functioning rates aggression, seclusion restraint, female adolescents severe disorder.Methods: Routinely collected data rate 15 adolescent females disorder admitted two secure mental...

Summary A 55 year old woman with multiple myeloma presented a pathological fracture of the right neck femur. Following internal fixation, and during subsequent radiotherapy, she developed small bowel obstruction. Laparotomy revealed an intussusception about deposit. This is previously unreported cause intussusception.

The clinical characteristics of 13 patients with Gender Dysphoria (GD) admitted to a mixed gender secure psychiatric hospital for adolescents were analysed. main finding was that all biologically female but identified as being male, at least some the time. very similar those service without identity issues. There are no other published studies within hospitals.

Many young people in forensic adolescent units require intramuscular medication for rapid tranquillization. The efficacy and safety of the medications used is not well reported this age group. Here we report a case 14-year-old girl experiencing severe oversedation respiratory compromise on two occasions following clonazepam.

In the 1870s St Lawrence's Hospital in Bodmin, Cornwall, had been running for 50 years, one of sixteen county asylums set up between 1811 and 1842. By examining 511 admissions 1870 1875 to this typical Victorian asylum we hoped shed light on mid-point era. The patients were all classified as 'paupers', whose publicly funded. A few privately funded admitted during period but are not included. Asylum populations rose greatly through 19th century. Whether rise was mainly due an increase...

Many patients maintained on depot medication have raised prolactin levels, which can lead to a range of long-term medical problems. The addition aripiprazole reduce levels and restore sexual function in these patients. cases described demonstrate the potential role forensic setting.

This article has used data provided by the Ministry of Justice to track changes in number adolescents under age 18 transferred from secure custodial institutions, who have required transfer psychiatric hospital using Section 47 and 48 Mental Health Act. During period 2004–2014 there were large reductions population young people detained custody England Wales. The requiring fell during this but a much lesser degree. possible reasons for are discussed include increased complexity availability beds.

Specialised forensic mental health provision for young people with disorders and high-risk behaviours has developed significantly in the UK. Despite this, research on within secure settings remains limited. Adolescents exhibit higher levels of have complex needs. This study aims to compare demographic characteristics patients discharged from an adolescent medium unit (AMSU) different discharge destinations: community, another hospital, or custodial setting.