A5075379369- Virus-based gene therapy research
- Veterinary Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Alcohol Consumption and Health Effects
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- Health, Work, and Social Studies in Poland
- Cystic Fibrosis Research Advances
- Natural Language Processing Techniques
- Nutrition and Health Studies
- Eicosanoids and Hypertension Pharmacology
- Microbial infections and disease research
- Oral and Maxillofacial Pathology
- interferon and immune responses
- Viral Infectious Diseases and Gene Expression in Insects
- Nasal Surgery and Airway Studies
- Gout, Hyperuricemia, Uric Acid
- Logic, programming, and type systems
- Adenosine and Purinergic Signaling
- Formal Methods in Verification
- Neonatal Respiratory Health Research
- Multiple Sclerosis Research Studies
- Social Issues in Poland
- Genetic and Kidney Cyst Diseases
University of Veterinary Medicine Hannover, Foundation
2020-2024
Chicago State University
2013-2017
Meditest
2005
Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of epithelium and compromises mucociliary clearance, thereby facilitating spread lungs paving way for secondary infections. A detailed understanding mechanism involved in ciliary loss subsequent regeneration is crucial assess possible long-term consequences COVID-19. The aim this study was characterize sequence histological ultrastructural changes observed during after infection golden Syrian hamster model. We...
Abstract Sarcomas especially of histiocytic origin often possess a poor prognosis and response to conventional therapies. Interestingly, tumours undergoing mesenchymal epithelial transition (MET) are associated with favourable clinical outcome. This process is characterized by an increased expression markers leading decreased invasion metastatic rate. Based on the failure therapies, viral oncolysis might represent promising alternative canine distemper virus (CDV) as possible candidate....
Oxidative stress and inflammation are major contributors to acrolein toxicity. Peroxisome proliferator activated receptor gamma (PPARγ) has antioxidant anti-inflammatory effects. We investigated the contribution of PPARγ ligand GW1929 attenuation oxidative in acrolein-induced insult. Male gp91phox knock-out (KO) mice were treated with (0.5 mg·(kg body mass)-1 by intraperitoneal injection for 7 days) or without (GW; 0.5 mass)-1·day-1, orally, 10 days). The livers processed further analyses....
Canine histiocytic sarcoma (HS) represents a neoplasia with poor prognosis. Due to the high metastatic rate of HS, there is urgency improve treatment options and prevent tumor metastases. distemper virus (CDV) single-stranded negative-sense RNA (ssRNA (-)) potentially oncolytic properties. Moreover, vasostatin granulocyte-macrophage colony-stimulating factor (GM-CSF) are attractive molecules in cancer therapy research because their anti-angiogenetic properties potential modulation...
Oncolytic viruses and morbilliviruses in particular, represent an interesting therapeutic approach for tumors with a poor prognosis frequent resistance to conventional therapies. Canine histiocytic sarcomas (HS) exemplify such neoplasm need new curative approaches. Previous investigations demonstrated limited success of acute intratumoral application canine distemper virus (CDV) on xenotransplanted sarcoma cells (DH82 cells), while persistently CDV-infected DH82 cell transplants exhibited...
The immune response plays a key role in the treatment of malignant tumors. One important molecule promoting humoral and cellular immunity is granulocyte-macrophage colony-stimulating factor (GM-CSF). Numerous successful trials have led to approval this immune-stimulating for cancer therapy. However, besides stimulation, GM-CSF may also accelerate tumor cell proliferation, rendering double-edged sword treatment. Therefore, detailed knowledge about vitro function produced by infected cells...
Abstract Theiler's murine encephalomyelitis virus (TMEV) induces an acute polioencephalomyelitis and a chronic demyelinating leukomyelitis in SJL mice. C57BL/6 (B6) mice generally do not develop TMEV-induced disease (TMEV-IDD) due to elimination. However, TMEV can persist specific immunodeficient B6 such as IFNβ −/− induce process. The proinflammatory cytokines IL-1β IL-18 are activated by the inflammasome pathway, which consists of pattern recognition receptor molecule sensing microbial...
Objective of this study was to identify the effect Peroxisome Proliferator Activated Receptor (PPAR) α induction on acrolein‐induced oxidative stress (OS) in gp91phox knockout mice. (KO) mice were treated with acrolein (Acr: 0.5μg/kg; i.p) with/without PPAR ligand Clofibrate (clof: 250mg/kg; i.p). Age/weight matched wild type (WT) used as control. KO had a higher (97%) 8‐Isoprostane response Acr than WT, and clof no effect. Total Antioxidant Status (TAS) significantly reduced more prominent...
PPARγ and its ability to influence oxidative stress (OS) has been the focus of inflammatory signaling. NAD(P)H oxidase enzyme, transcriptionally regulated by provides oxidant in acrolein (Acr)‐induced OS. We explored ligand GW1929 (GW) on OS induced Acr mice lacking gp91phox subunit oxidase. GW reduced tissue 8‐Isoprostane both WT KO 35% 43% (p<0.05) respectively, which was increased Acr. Total Antioxidant Status (TAS) is more marked (61%) than (54%) mice. enhances TAS but did not affect...
Regular expressions -- regexes are widely used not only for validating, but also parsing textual data. Generally, regex parsers output a loose structure, e.g. an unstructured list of matches, leaving it up to the user validate output's properties and transform into desired structure. Since itself carries information about this design leads unnecessary repetition. Radanne introduced typed TyRE type-indexed combinator layer that can be added on top existing engine. We extend Radanne's design,...
Einleitung Die virale Onkolyse rückt immer mehr in den Fokus der Tumorforschung. Bei früheren Versuchen wurde eine transiente Stagnation des Tumorwachstums bei akuter Infektion von kaninen histiozytären Sarkomzellen (DH82-Zellen) mit dem CDV erzielt. Im Folgenden Einfluss einer persistierenden untersucht.