A5022197288- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Research Topics
- Maternal Mental Health During Pregnancy and Postpartum
- Early Childhood Education and Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Adolescent and Pediatric Healthcare
- Health, psychology, and well-being
- Attention Deficit Hyperactivity Disorder
- Mindfulness and Compassion Interventions
- Cognitive Abilities and Testing
- Behavioral Health and Interventions
- Bipolar Disorder and Treatment
- Optimism, Hope, and Well-being
- Treatment of Major Depression
- Long-Term Effects of COVID-19
- Family Caregiving in Mental Illness
- Perfectionism, Procrastination, Anxiety Studies
- Genetic Associations and Epidemiology
- Psychological and Temporal Perspectives Research
- Behavioral and Psychological Studies
- Functional Brain Connectivity Studies
- Family Support in Illness
- S100 Proteins and Annexins
Massachusetts General Hospital
2022-2025
Temple University
2017-2024
University Medical Center Groningen
2024
University of Groningen
2024
University of Bristol
2024
Bristol Regional Medical Center
2024
Harvard University
2023-2024
Temple College
2018-2022
University College Dublin
2015-2016
Objectives The aim of this study is to examine the risk and protective factors associated with anxiety depression in a representative sample Irish adolescents. Methods Data used were drawn from subset My World Survey (MWS). MWS-Second Level (MWS-SL) consists randomised 72 schools, final 6085 students. Outcome measures anxiety. Risk included within socio-demographic, psychosocial risk-taking domains. Results One three adolescents experienced elevated levels Age, gender, maternal education,...
Inflammation has been implicated in depressive symptoms, but few studies use longitudinal designs with adolescents. Furthermore, the extant literature yielded inconsistent results. Blood was collected from a community sample of 201 adolescents (109 female, ages 12.3-20.0) and analyzed for inflammatory proteins. Up to five follow-up assessments symptoms were conducted. Multi-level modeling indicated that high C-reactive protein (CRP) (but no other proinflammatory markers) predicted symptom...
Abstract Background There is substantial evidence that many depressed individuals experience impaired executive functioning. Understanding the causes of dysfunction in depression clinically important because cognitive impairment a contributor to functional impairment. This study investigated whether elevated levels an inflammatory cytokine [interleukin-6 (IL-6)] and/or higher body mass index (BMI) concurrently prospectively accounted for relationship between depressive symptoms and...
There are inconsistent findings in the literature about directionality and magnitude of association between inflammation depressive symptoms. This analysis separates predictors into between-persons within-person components to gain greater clarity this relationship. Blood samples were collected symptoms assessed 140 adolescents (54% female, 59% Black; mean age = 16.1 years) with at least three blood draws a total 394 follow-up observations. Multilevel modeling indicated that within-persons...
The hopelessness theory of depression is a prominent account that posits individuals with negative inferential style are more likely to become hopeless when they experience life events (NLEs) and proximal cause depression. There strong evidence supporting the role in pathogenesis major depression; however, substantially less known about proposed played by hopelessness. cornerstone hypothesis theory, depression, largely untested. A small number studies have generated inconclusive mediates...
Cognitive vulnerability theories of depression outline multiple, distinct inferential biases constitutive cognitive to depression. These include attributing negative events internal, stable, and global factors, assuming that will lead further consequences, inferring reflect characteristics about the self. Extant research has insufficiently examined these as distinct, limiting our understanding how individual components interrelate confer risk for symptoms. Thus, we conducted exploratory...
There is convergent evidence that the immune system dysregulated in some depressed individuals. A psychoneuroimmunology-based understanding of depression advancing rapidly; however, a question fundamental importance poorly understood: does inflammation play causal role etiology or are elevated inflammatory biomarkers downstream effect depressive behaviors? Although longitudinal studies suggest relationship between and characterized by complex bidirectional associations, existing prospective,...
Importance Prenatal maternal inflammation has been associated with major depressive disorder in offspring adulthood as well internalizing and externalizing symptoms childhood; however, the association between prenatal depression adolescence yet to be examined. Objective To determine whether levels of inflammatory biomarkers during pregnancy are symptomatology adolescent-aged examine how gestational timing, sex, childhood psychiatric impact these associations. Design, Setting, Participants...
To characterize adults with comorbid attention-deficit/hyperactivity-disorder (ADHD) and borderline personality disorder (BPD) regard to ADHD symptoms, psychopathology, cognitive functioning psychosocial factors.A between-group design compared a group of individuals diagnosed (n=40) BPD who also met the criteria for (ADHD+BPD) (n=20).Significant differences were observed both childhood current impulsivity whereby ADHD+BPD exhibited increased impulsivity; no on self-report measures reported....
Given that carers of individuals with intellectual disability (ID) and psychiatric disorders experience elevated levels stress psychological distress, both ID a comorbid disorder are potentially at even greater risk for difficulties. The aim the present study was to investigate well-being adults dual diagnosis compared alone.Four-hundred forty-two questionnaires were sent four community services seventy-five family responded. Psychological assessed using Questionnaire on Resources Stress -...
<title>Abstract</title> Inflammation is associated with a range of neuropsychiatric symptoms; however, the nature causal relationship unclear. We used complementary non-genetic, genetic risk score (GRS), and Mendelian randomization (MR) analyses to examine whether inflammatory markers are affect, depressive anxiety disorders, cognition. tested in ≈ 55,098 (59% female) individuals from Dutch Lifelines cohort concurrent/prospective associations C-reactive protein (CRP) with: disorders;...
It is unclear whether impaired cognition a risk factor for depression, consequence of or both depression and are caused by third underlying process (e.g., stress). These three hypotheses were tested in 523 adolescents assessed annually attentional functioning, childhood/recent life stress. Baseline switching, sustained, selective attention did not predict first onset (foD) depressive symptoms. Divided predicted symptoms only. Piecewise growth modelling indicated that the trajectory switching...
Residence in high-crime neighborhoods, especially childhood, is linked to mental health issues later. Detecting distinct neurobiological processes underlying the effects of this environmental stressor may be critical identifying prevention and intervention targets. This study examined relationships levels a circulating inflammatory protein with social monetary reward–related brain function among adolescents who lived high- versus low-crime neighborhoods during childhood. A total 70...