A5057636026- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Synthetic Organic Chemistry
- Organic and Inorganic Chemical Reactions
- Monoclonal and Polyclonal Antibodies Research
- Synthesis and Biological Evaluation
- Protein Structure and Dynamics
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Synthesis and biological activity
- Chemical Reactions and Isotopes
- Analytical Chemistry and Chromatography
- Synthesis of heterocyclic compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inorganic and Organometallic Chemistry
- Enzyme Structure and Function
- Bioactive Compounds and Antitumor Agents
- Biochemical and Structural Characterization
- Spectroscopy and Quantum Chemical Studies
- Microbial Metabolic Engineering and Bioproduction
- Ferroptosis and cancer prognosis
- Quinazolinone synthesis and applications
University of Minnesota
2024
University at Buffalo, State University of New York
2022
Shiv Nadar University
2017-2020
Technical University of Denmark
2005
Carbonyl-carbonyl n→π* interactions where a lone pair (n) of the oxygen atom carbonyl group is delocalized over π* orbital nearby have attracted lot attention in recent years due to their ability affect 3D structure small molecules, polyesters, peptides, and proteins. In this paper, we report discovery "reciprocal" carbonyl-carbonyl interaction with substantial back forth π→π* electron delocalization between neighboring groups. We carried out experimental studies, analyses crystallographic...
Abstract We report on our work with vibrational absorption, circular dichroism, Raman scattering, optical activity, and surface‐enhanced spectroscopy to study protein DNA structure, hydration, the binding of ligands, drugs, pesticides, or herbicides via a combined theoretical experimental approach. The systems we have studied systematically are amino acids ( L ‐alanine, ‐tryptophan, ‐histidine), peptides N ‐4271 acetyl ‐alanine ′‐methyl amide, ‐acetyl ‐tryptophan ‐histidine ‐alanyl tri‐...
Chronic inflammation plays a central role in the pathogenesis of lung diseases including asthma, long COVID, chronic obstructive pulmonary disease (COPD), and cancer. Lipopolysaccharide (LPS) is potent inflammatory agent produced by Gram-negative bacteria also found cigarette smoke. Our earlier study revealed that intranasal exposure A/J mice to LPS for 7 days altered gene expression levels alveolar type II epithelial cells (AECII), which serve as precursors adenocarcinoma are preferentially...
Chronic inflammation plays a central role in the pathogenesis of lung diseases including asthma, long COVID, chronic obstructive pulmonary disease (COPD), and cancer. Lipopolysaccharide (LPS) is potent inflammatory agent produced by Gram-negative bacteria also found cigarette smoke. Our earlier study revealed that intranasal exposure A/J mice to LPS for 7 days altered gene expression levels alveolar Type II epithelial cells (AECIIs), which serve as precursors adenocarcinoma are...
Here we report the design of N2 -carboxy-4-aryl-1,2,3-triazole-lysines (CATKs) and their site-specific incorporation into proteins via genetic code expansion. When introduced protein dimer interface, CATKs permitted spontaneous, proximity-driven, site-selective crosslinking to generate covalent dimers in living cells, with phenyl-bearing CATK-1 exhibiting high reactivity toward proximal Lys Tyr. Furthermore, when N-terminal β-strand either a single-chain VHH antibody or supercharged...
The incorporation of the recently discovered reciprocal n → π* interactions in 2,5-diketopiperazines (DKPs) is reported to design a novel N, N'-di(acylamino)-2,5-diketopiperazine (daa-DKP) scaffold. design, synthesis, and structural features daa-DKPs effect their rigidity discussed.
We report the solid-phase synthesis of N,N′-di(acylamino)-2,5-diketopiperazine, an acylhydrazide-based conformationally rigid 2,5-DKP scaffold having exocyclic N–N bonds. also show that different combinations acylhydrazides, carbazates, semicarbazides, amino acids, and primary amines can be used to synthesize a highly diverse collection hybrid DKP molecules via submonomer route. Finally, we incorporation methyl substituent in one carbon atoms ring generate chiral daa- hybrid-DKPs without...
Some pyrimidin-2- and pyrimidin-4-amines were treated with isocyanates isothiocyanates to give the corresponding disubstituted ureas or thioureas . A pyrimidin-2-amine is more reactive than a pyrimidin-4- amine in these reactions. 2-Aminothiazoles thiazolinones also react The use of ethoxycarbonyl benzoyl isothiocyanate isocyanate gives products which are readily hydrolysed pyrimidinyl thiazolyureas but concomitant hydrolysis decarboxylation an substituent chlorosulfonyl trimethylsilyl urea...
Abstract Ten-Eleven Translocation (TET1-3) dioxygenases oxidize 5-methylcytosine (5mC) in DNA to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), initiating demethylation. The three proteins share significant sequence homology catalyze the same chemical reaction utilizing alpha-ketoglutarate cofactor non-heme iron methyl group of 5mC. Since their discovery 2009, there have been contradictory reports regarding roles TET cancer. genes...
In the alkaline hydrolysis of carboxylic esters in ‘70% dioxan’ solution rate coefficients for anthraquinone-2-esters are ca. 50 times as fast, and anthraquinone-1-esters 1/20 those corresponding benzoates. The very low rates 1-esters due to entropies activation, high 2-esters mainly relatively enthalpies activation.
The kinetics of hydrolysis some methyl, ethyl, isopropyl, and t-butyl esters substituted benzoic acids were studied in 70% v/v dioxan–water. substituent effects their additivity examined. the methyl benzoates follows sequence relative rates (at 40°) 4-nitro 71, 2-methyl-4-nitro 11, parent 1.0, 3-methyl 0.71, 4-methyl 0.51, 2-methyl 0.14, 2,5-dimethyl 0.090, 2.3-dimethyl 0.065, 2,4-dimethyl 0.055. 2-ethyl 0.046.