A5059206054- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Memory and Neural Mechanisms
- Axon Guidance and Neuronal Signaling
- Lipid Membrane Structure and Behavior
- Pluripotent Stem Cells Research
- Immune cells in cancer
- MicroRNA in disease regulation
- Intensive Care Unit Cognitive Disorders
- Genetics and Neurodevelopmental Disorders
- Neuroscience, Education and Cognitive Function
- Glioma Diagnosis and Treatment
Universidad Autónoma de Madrid
2017-2024
Centro de Biología Molecular Severo Ochoa
2017-2024
Biomedical Research Networking Center on Neurodegenerative Diseases
2017-2024
Consejo Superior de Investigaciones Científicas
2019
Disrupted hippocampal performance underlies psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. To understand the contribution of adult neurogenesis (AHN) to amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s dementia Lewy bodies, frontotemporal dementia, we studied postmortem human samples. We found that adult-born dentate granule cells showed abnormal morphological development changes expression differentiation markers. The ratio...
Microglia are immune cells that play a crucial role in maintaining brain homeostasis. Among the mechanisms of communication between microglia and neurons, CX3CL1/CX3CR1 axis exerts central modulatory role. Animals lacking CX3CR1 microglial receptor (CX3CR1−/− mice) exhibit marked alterations not only but also neurons located various regions brain. Here we show depletion leads to deficient synaptic integration adult-born granule dentate gyrus (DG), both at afferent efferent level. Regarding...
Abstract Tau is a neuronal microtubule-associated protein with countless physiological functions. Although the detrimental effects of insoluble aggregated have been widely studied, recent evidence supports notion that soluble (composed mostly monomers and dimers) also toxic for neurons. Here we evaluated long-term impact single stereotaxic injection human on hippocampal granule neurons in mice. At ultrastructural level, reduced number afferent synapses caused dramatic depletion synaptic...
The mammalian hippocampus can generate new neurons throughout life. Known as adult hippocampal neurogenesis (AHN), this process participates in learning, memory, mood regulation, and forgetting. continuous incorporation of enhances the plasticity contributes to cognitive reserve aged individuals. However, integrity AHN is targeted by numerous pathological conditions, including neurodegenerative diseases sustained inflammation. In regard, latter causes decline, alterations, multiple...
Adult hippocampal neurogenesis (AHN) gives rise to new neurons throughout life. This phenomenon takes place in more than 120 mammalian species, including humans, yet its occurrence the latter was questioned after one study proposed putative absence of markers adult human hippocampus. In this regard, we showed that prolonged fixation impedes visualization Doublecortin+ immature structure, whereas other authors have suggested a dilated post-mortem delay (PMD) underlies these discrepancies....
Frontotemporal dementia (FTD) is characterized by neuronal loss in the frontal and temporal lobes of brain. Here, we provide first evidence striking morphological alterations dentate granule cells (DGCs) FTD patients a mouse model disease, TauVLW mice. Taking advantage fact that hippocampal gyrus (DG) gives rise to newborn DGCs throughout lifetime rodents, used RGB retroviruses study temporary course these female In addition, encode either PSD95:GFP or Syn:GFP revealed afferent efferent...
Newborn dentate granule cells (DGCs) are generated in the hippocampal gyrus (DG) of rodents through a process called adult neurogenesis, which is subjected to tight intrinsic and extrinsic regulation. The use retroviruses encoding fluorescent proteins has allowed characterization maturation dynamics newborn DGCs, including their morphological development establishment afferent efferent synaptic connections. However, study crucial cellular compartment these cells, namely, axon initial segment...
Abstract Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. is impaired in neurological disorders, yet molecular mechanisms regulating maturation synaptic integration of new neurons have not been fully elucidated. GABA a master regulator adult developmental neurogenesis. Here we engineered novel retrovirus encoding fusion protein Gephyrin:GFP longitudinally study formation inhibitory synapses vivo. Our data reveal early assembly...
Cholesterol, a crucial component of cell membranes, influences various biological processes, including membrane trafficking, signal transduction, and host-pathogen interactions. Disruptions in cholesterol homeostasis have been linked to congenital acquired conditions, neurodegenerative disorders such as Alzheimer's disease (AD). Previous research from our group has demonstrated that herpes simplex virus type I (HSV-1) induces an AD-like phenotype several models infection. This study explores...
Abstract Background Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by loss of neurons in the frontal and temporal lobes brain. Tau protein encoded MAPT gene its mutations cause FTD‐Tau, FTD variant. TauVLW mice carries three mutations, G272V (V), P301L (L), R406W (W) on MAPT, increasing susceptibility to be phosphorylated. show anatomical alterations hippocampus as well behavioural impairments. Importantly, gives rise new throughout life. This process, named...
Abstract Background Alzheimer´s disease (AD) is a devastating neurodegenerative disorder. The hippocampus, one of the brain areas primarily affected by progression, hosts most unique phenomena that occur in adult mammalian brain. This phenomenon, named hippocampal neurogenesis (AHN), encompasses addition new neurons throughout life, crucial for hippocampal‐dependent learning, and confers an unparalleled degree plasticity to entire circuitry. During AHN, rodents, newborn dentate granule cells...
Abstract Background Alzheimer’s disease (AD) is the most common type of dementia. This devastating characterized by progressive memory impairments and other behavioral alterations. The hippocampus one brain areas mostly affected AD progression. Importantly, hosts a unique phenomenon that occurs in mammalian brain, namely addition new neurons throughout life. process, named adult hippocampal neurogenesis (AHN), involved hippocampal‐dependent confers an extraordinary degree plasticity to...