About
Contact & Profiles
A5011717370
Research Areas
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- T-cell and B-cell Immunology
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
Yale University
2021
Abstract Background Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation TADs has been shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances an image-based spatial genomics technique known as chromatin tracing lead the discovery cohesin-independent TAD-like structures, also single-cell domains, which highly variant self-interacting with boundaries that occasionally overlap TAD but tend differ...
10.1186/s13059-021-02523-8
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cc-by
Genome biology
2021-11-08
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