A5103003252- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Radiation Dose and Imaging
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Tracheal and airway disorders
- Pneumothorax, Barotrauma, Emphysema
- Tuberous Sclerosis Complex Research
- Congenital Diaphragmatic Hernia Studies
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Thyroid and Parathyroid Surgery
- Cancer, Hypoxia, and Metabolism
- Myasthenia Gravis and Thymoma
Hyogo University
2022-2025
Hyogo Medical University
2014-2023
Osaka University
2020
Thoracic Surgery Foundation
2010-2012
Kyoto University
2008-2010
Shimane Prefectural Central Hospital
2000
Kyushu University
1993
Meijo University
1989
To investigate the diagnostic performance of circulating tumor cells (CTC) in discrimination between primary lung cancer and nonmalignant diseases as well prediction distant metastasis.We prospectively evaluated CTCs 7.5-mL samples peripheral blood sampled from patients with a suspicion or diagnosis cancer. A semiautomated system was used to capture an antibody against epithelial cell adhesion molecule.Of 150 eligible patients, 25 were finally diagnosed having disease, 125 (n = 31) without...
In the present study, we analyzed genomic alterations of BRCA1-associated protein 1 (BAP1) in 23 malignant mesotheliomas (MMs), 16 epithelioid and seven non-epithelioid, consisting 18 clinical specimens five established cell lines. examining these samples for homozygous deletions sequence-level mutations, found biallelic BAP1 gene 14 MMs (61%). Seven had partial or entire gene, another including small deletions, a nonsense mutation, missense mutations with additional monoallelic remaining...
Circulating tumour cells (CTCs) are shed from a primary and circulate in the peripheral blood after passing through drainage vein. In previous studies, we showed that high numbers of CTCs were detected pulmonary venous most patients with resectable lung cancer, whereas only low some patients. Accordingly, this prospective study was conducted to assess changes vein (PV) during cancer surgery. A total 30 consecutive peripheral-type who underwent lobectomy (or right upper middle bilobectomy)...
症例は47歳男性.明らかなアスベスト曝露歴は有さず,19歳時にHodgkinリンパ腫に罹患し,化学療法および胸部への放射線治療(マントル照射)を受け,寛解していた.発熱,胸痛,呼吸苦を契機に右胸水貯留を指摘され,精査の結果,胸膜中皮腫(上皮様)の診断に至った.集学的治療の適応と判断し,胸膜切除/肺剥皮術と化学療法による集学的治療が施行された.食道との癒着が高度で,術後に食道胸腔瘻による膿胸を発症したため,大網充填術を行った.術後5年目に同側胸腔内に局所再発をきたしたものの薬物療法により消失し術後7年が経過するが生存中である.過去の放射線治療によって発症したと思われた胸膜中皮腫の一例を経験した.アスベスト曝露歴を有さない胸膜中皮腫患者においては胸部放射線治療の既往の聴取が重要である.また手術を行う際には縦隔への放射線治療による高度な癒着が懸念されるため注意が必要である.
In non-small cell lung cancer (NSCLC), circulating tumor cells (CTC) are shed and circulate to the peripheral blood through pulmonary vein. Previously, CTC count in venous (pvCTC) was shown significantly increase after surgical manipulation. Therefore, we assessed correlation between changes pvCTC (ΔpvCTC) clinical outcomes.Consecutive patients with peripheral-type, NSCLC, who underwent lobectomy or bi-lobectomy open thoracotomy, were enrolled prospectively. Before lobectomy, 2.5 mL of drawn...
Abstract Malignant pleural mesothelioma (MPM) is an asbestos‐related aggressive malignant neoplasm. Due to the difficulty of achieving curative surgical resection in most patients with MPM, a combination chemotherapy cisplatin and pemetrexed has been only approved regimen proven improve prognosis MPM. However, median overall survival time at 12 mo even this regimen. There therefore pressing need develop novel chemotherapeutic strategy bring about better outcome for We found that expression...
Alveolar adenoma is a rare pulmonary neoplasm. This report describes case of alveolar the lung in 61-year-old woman. A chest X-ray demonstrated solitary round nodule. After six years observation, this lesion had increased size. Thoracoscopic left upper segmentectomy was performed on account possible low-grade malignant tumor. Histologically, neoplastic epithelial cells, which appearance proliferative type II pneumocytes, revealed no evidence malignancy. These findings indicated that tumor...
Background/Aim: To evaluate the incidence and grade of radiation pneumonitis after volumetric modulated arc therapy (VMAT) performed for treatment non-small cell cancer (NSCLC). Patients Methods: Fifty consecutive non-surgical candidates with NSCLC underwent VMAT. Thirty-five patients had stage-III tumors 15 recurrent tumors. The prescribed dose gross tumor elective nodal area was 69 Gy in 30 fractions 51 fractions, respectively. Results: Radiation developed 38 (76%, 38/50), ≥2 11 (22%,...
Abstract Background Limited options exist for treating post-recurrence patients with malignant pleural mesothelioma (MPM). This study aimed to evaluate the efficacy and feasibility of nivolumab in post-operative recurrence MPM a real-world setting. Methods included 35 MPM. Treatment consisted 240-mg intravenous administration every 2 weeks until progressive disease (PD) or serious adverse events (AEs). Additional post-treatment data were evaluated, including objective response rate (ORR),...
Background: Circulating tumour cells (CTCs) are a potential surrogate for distant metastasis and considered useful clinical prognostic marker metastatic colorectal cancer (mCRC). This prospective study evaluated the preoperative CTC count as factor pulmonary metastasectomy in mCRC patients. Methods: Seventy-nine patients who underwent curative-intent were included. Preoperatively, 7.5 mL of peripheral blood from each patient was quantitatively CTCs with CellSearch® system. The significance...