A5003747920- Myasthenia Gravis and Thymoma
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Transplantation: Methods and Outcomes
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Cardiac tumors and thrombi
- Cancer Cells and Metastasis
- Tracheal and airway disorders
- Cancer Immunotherapy and Biomarkers
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Thyroid and Parathyroid Surgery
- Occupational and environmental lung diseases
- Immunotherapy and Immune Responses
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
Osaka University
2016-2025
Hyogo University
2024-2025
Osaka University Hospital
2018-2024
The Radiosurgery Society
2023
First Pavlov State Medical University of St. Petersburg
2021
Tokyo Women's Medical University Yachiyo Medical Center
2015
University of Occupational and Environmental Health Japan
2015
Tokyo Women's Medical University
2015
Takarazuka City Hospital
2006-2007
PD-1 blockade exerts antitumor effects by reinvigorating tumor antigen–specific CD8+ T cells. Whereas neoantigens arising from gene alterations in cancer cells comprise critical antigens immunity, a subset of non–small cell lung cancers (NSCLCs) harboring substantial mutation burden (TMB) lack the microenvironment (TME), which results resistance to therapy. To overcome this resistance, clarifying mechanism(s) impairing immunity highly mutated NSCLCs is an urgent issue. Here, we showed that...
Abstract Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the etiologic factors for are not well understood. Here, constructing comprehensive atlas of using bulk and single-cell RNA-sequencing, we identify ectopic expression neuromuscular molecules MG-type thymoma. These found within distinct subpopulation medullary thymic epithelial cells (mTECs), which name mTECs (nmTECs)....
Although video-assisted thoracoscopic thymectomy (VATS-Tx) for thymoma has been introduced, its oncological outcome remains unclear. Our institutional experience with early-stage was retrospectively reviewed to evaluate the feasibility of thymectomy.A retrospective review consisting 74 patients Masaoka Stage I and II thymomas who had undergone performed. Forty-five underwent thymectomy, while 29 through open sternotomy approach. The clinical factors associated surgical outcome, including...
Most patients suffering from cancer die of metastatic disease. Surgical removal solid tumors is performed as an initial attempt to cure patients; however, surgery often accompanied with trauma, which can promote early recurrence by provoking detachment tumor cells into the blood stream or inducing systemic inflammation both. We have previously reported that administration atrial natriuretic peptide (ANP) during perioperative period reduces inflammatory response and has a prophylactic effect...
Abstract Targeting cancer-associated fibroblasts (CAFs), as well the crosstalk between stroma and cancer cells, could be of value in managing cancers. Pirfenidone (PFD) is an anti-fibrotic agent for idiopathic pulmonary fibrosis. This study aimed to investigate possibility that PFD might exert anti-tumor effect through inhibition fibroblast activation tumor-stroma interaction non-small cell lung (NSCLC) lines vitro vivo. significantly inhibited myofibroblast differentiation both primary...
Abstract Alveolar macrophages (AMs) are crucial for maintaining normal lung function. They abundant in cancer tissues, but their pathophysiological significance remains unknown. Here we show, using an orthotopic murine model and human carcinoma samples, that AMs support cell proliferation thus contribute to unfavourable outcome. Inhibin beta A (INHBA) expression is upregulated under tumor-bearing conditions, leading the secretion of activin A, a homodimer INHBA. Accordingly, follistatin,...
Abstract Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, inhibitors are only advantageous for a limited population of Therefore, companion diagnostics needed order to identify patients whom these therapies effective. In the present study, we evaluated detailed immunological aspects clinical specimens from non-small cell lung (NSCLC) We analyzed profiles, T cytotoxicity, and TCR repertoire peripheral blood, normal tissue,...
Alterations to the tumor stromal microenvironment induced by chemotherapy could influence behavior of cancer cells. In microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because receptor tyrosine kinase Axl and its ligand Gas6 be involved in promoting non-small cell lung (NSCLC), we investigated role secreted CAFs during NSCLC. a murine model, found that expression was upregulated following cisplatin treatment. might influenced intratumoral hypoperfusion...
Abstract Background CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8 + Tregs their interaction with CD8 in the tumor microenvironment human lung cancer. We evaluated spatial distribution impact cell effector function, specifically granzyme B (GzmB) expression, clinical outcomes. Methods A total 81 patients squamous carcinoma (LSCC) who underwent radical...
Secondary aorto-oesophageal fistulas after thoracic endovascular aortic repair are a severe complication associated with high mortality rates. We present case of staged oesophageal decompression performed via thoracoscopic resection residual aneurysm following to prevent secondary in patient distal arch causing significant compression. A 70-year-old woman 3-month history hoarseness was referred our hospital. Computed tomography revealed penetrating ulcer the arch, complicated by 60 mm...
Objective: The presence of isolated tumor cells (ITCs) in the pulmonary vein (PV) a lung resected for cancer has been reported to be prognostic factor. Previous investigations noted correlations between prognosis and or amount ITCs, although few studies have investigated clinical implications morphological characteristics those cells. We assessed ITCs PV using novel enrichment approach that maintained their characteristics. Methods: Ninety-four consecutive patients with primary...
Abstract Primordial germ cells (PGCs) can give rise to pluripotent stem known as embryonic (EGCs) when cultured with basic fibroblast growth factor (bFGF), cell (SCF), and leukemia inhibitory factor. Somatic induced (iPSCs) by introduction of the reprogramming transcription factors Oct4, Sox2, Klf4. The effects Sox2 Klf4 on somatic be reproduced using small molecule compounds, transforming factor-β receptor (TGFβR) inhibitor Kempaullone, respectively. Here we examined TGFβR Kempaullone EGC...