Chun-Kai Wen

ORCID: 0000-0003-4250-607X
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About
Contact & Profiles
Research Areas
  • Case Reports on Hematomas
  • Pancreatic and Hepatic Oncology Research
  • COVID-19 and Mental Health
  • Virus-based gene therapy research
  • Genetic factors in colorectal cancer
  • Nutritional Studies and Diet
  • Sarcoma Diagnosis and Treatment
  • RNA modifications and cancer
  • COVID-19 Pandemic Impacts
  • Intraperitoneal and Appendiceal Malignancies
  • Omental and Epiploic Conditions
  • CAR-T cell therapy research
  • Obesity, Physical Activity, Diet
  • Cancer-related molecular mechanisms research
  • Cancer Immunotherapy and Biomarkers
  • Obesity and Health Practices
  • Cancer-related Molecular Pathways

Kaohsiung Medical University
2017-2025

Kaohsiung Medical University Chung-Ho Memorial Hospital
2017-2025

Tumor Hospital of Guangxi Medical University
2020-2021

Guangxi Medical University
2020

Chung Shan Medical University
2014

University of Southern California
2014

Cdk1 (cyclin-dependent kinase 1) is critical regulator of the G2-M checkpoint. Cyclin-dependent pathways are considered possible targets for cancer treatment; however, prognostic role in colorectal still controversial. Therefore, we attempted to determine impact on clinical outcome patients further identify its cancer. immunoreactivity was analyzed by immunohistochemistry (IHC) 164 specimens from primary patients. The medium follow-up time after surgery 3.7 years (range: 0.01 13.10 years)....

10.1186/1471-2407-14-951 article EN cc-by BMC Cancer 2014-12-01

Effective therapeutic strategies for triple-negative breast cancer (TNBC) are still lacking. Clinical data suggest that a large number of TNBC patients cannot benefit from single immune checkpoint inhibitor (ICI) treatment due to the immunosuppressive tumour microenvironment (TME). Therefore, combination immunotherapy is an alternative approach overcome this limitation. In article, we combined two kinds oncolytic adenoviruses with ICIs treat in orthotopic mouse model. Histopathological...

10.1038/s41417-021-00389-3 article EN cc-by Cancer Gene Therapy 2021-09-24

Evidences shows that immune and stroma related genes in the tumour microenvironment (TME) play a key regulator prognosis of Osteosarcomas (OSs).The purpose this study was to develop TME-related risk model for assessing OSs.82 OSs cases aged ≤25 years from TARGET were divided into two groups according immune/stromal scores analyzed by Estimate algorithm.The differentially expressed (DEGs) between 122 DEGs revealed.Finally, three (COCH, MYOM2 PDE1B) with minimum AIC value derived multivariate...

10.18632/aging.202170 article EN cc-by Aging 2020-12-03

Rationale: Idiopathic omental bleeding is a rare cause of acute abdomen, with only few reported cases. It usually presents abdominal pain and may be life-threatening. As it rarely occurs, not considered initially during patient presentation. Patient concerns: A 35-year-old male came to our emergency department present for around 5 6 hours. The complained left upper quadrant after eating breakfast. associated symptom was 3 episodes vomiting up food. Physical examination revealed mild...

10.1097/md.0000000000009463 article EN cc-by-nc Medicine 2017-12-01
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