A5010978795- Genomics and Phylogenetic Studies
- Aquaculture disease management and microbiota
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Heavy metals in environment
- Epigenetics and DNA Methylation
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Bacterial Genetics and Biotechnology
- Medicinal Plants and Neuroprotection
- Identification and Quantification in Food
- Neuroscience and Neuropharmacology Research
- Marine Sponges and Natural Products
- Cancer-related molecular mechanisms research
- Arsenic contamination and mitigation
- Radioactivity and Radon Measurements
- Protein Degradation and Inhibitors
- Atherosclerosis and Cardiovascular Diseases
- Innovations in Concrete and Construction Materials
- Cardiac Health and Mental Health
- Genetics and Physical Performance
- Pharmacological Effects of Medicinal Plants
- Biomarkers in Disease Mechanisms
- Cancer, Hypoxia, and Metabolism
- Dye analysis and toxicity
Shanxi Medical University
2022-2025
Peking University First Hospital
2024
Peking University
2024
Shanghai Jiao Tong University
2022-2023
Taiyuan Central Hospital
2022
Hong Kong Baptist University
2020
Hefei University of Technology
2015-2019
Hefei University
2015-2017
Xi'an Jiaotong University
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2007
Compromised learning and memory is a common feature of multiple neurodegenerative disorders. A paradigm spatial impairment could be caused by developmental lead (Pb) exposure. Growing evidence implicates epigenetic modifications in the Pb-mediated deficits; however, how histone exemplified H3K27me3 (H3 Lys27 trimethylation) contribute to this pathogenesis remains poorly understood. Here we found that Pb exposure diminished levels vivo suppressing EZH2 (enhancer zeste homolog 2) expression at...
This investigation compares the effects of two exercise prescriptions with equal energy consumption but different intensity-determination methods on cardiopulmonary endurance in a population metabolic syndrome (MetS). verified effectiveness individualized patients MetS undergoing moderate-intensity exercises. The participants were randomized into standardized group or group. Exercise intensity was determined based heart rate reserve method and ventilatory threshold model groups completed 12...
Lead (Pb) exposure, in particular during early postnatal life, increases susceptibility to cognitive dysfunction and neurodegenerative outcomes. The detrimental effect of Pb exposure is basically due an increasing ROS production which overcomes the antioxidant systems finally leads dysfunction. Kiwifruit rich antioxidants like vitamin C polyphenols. This study aims investigate effects mechanism kiwifruit alleviate learning memory deficits induced by exposure. Sprague-Dawley (SD) rat pups...
Chronic lead (Pb) exposure causes cognitive deficits. This study aimed to explore the neuroprotective effect and mechanism of β-asarone, an active component from Chinese Herbs Acorus tatarinowii Schott, alleviate impairments spatial memory synaptogenesis in Pb-exposed rats. Both Sprague-Dawley developmental rat pups adult rats were used study. Developmental exposed Pb throughout lactation period β-asarone (10, 40mg kg-1, respectively) was given intraperitoneally postnatal day 14 21. Also,...
NDR1/2 kinase is essential in dendrite morphology and spine formation, which regulated by cellular Ca2+. Lead (Pb) a potent blocker of L-type calcium channel our recent work showed Pb exposure impairs dendritic outgrowth hippocampal neurons rats. But the sensitivity Pb-induced maturity with mixed factors (gender×age×brain regions) remains unknown. This study aimed to systematically investigate effect on rat brain three regions), as well expression. Sprague–Dawley rats were exposed from...
Epigallocatechin-3-gallate (EGCG) may significantly reverse Pb-related spine damage in developing rats by increasing the expression of Wnt7a and activity Wnt/β-catenin pathway.
EZH2 plays vital roles in epigenetic regulation, neuronal development and cancer progression.Here a novel variant, namely EZH2-X9 (X9 for short) resulting from alternative splicing, was isolated, identified functionally characterized.X9 highly expressed the brains of SD rats, indicating potentially distinguished role central nervous system (CNS).Owing to transcript profiling, X9 enriched multiple brain regions at very early stage life.Immunostaining validated presence protein form X9, which...
In this study, six bacterial isolates with variable GC, including Escherichia coli as mesophilic reference strain, were selected to compare hybrid assembly strategies based on next-generation sequencing (NGS) of short reads, single-tube long-fragment reads (stLFR) sequencing, and Oxford Nanopore Technologies (ONT) platforms. We obtained the complete genomes using assembler Unicycler NGS ONT reads; others de novo assembled NGS, stLFR, by different strategies. The contiguity, accuracy,...
Pb is a pervasive environmental threat to human health. Although remarkable progress has been made in its neurotoxicity, the precise molecular mechanisms underlying this widespread toxicant still remain elusive. In study, detailed roles of EZH2, transcriptional repressor, regulation Pb-led neurotoxicity were investigated, highlighting sub-functionalization, compartmentalization, functional chaperones and downstream partners. Based on findings, EZH2's protein levels significantly reduced...
Elevation of brain magnesium enhances cognitive capacity.
Abstract Purpose This study aimed to compare differences and consistencies between the target heart rate (THR) for aerobic exercise based on standardized physiological maximum value percentage first-ventilatory-threshold (HR VT1 ). The with highest consistency HR , combined max ) prediction equation, can guide safe effective in patients metabolic syndrome (MetS) practical applications. Methods Three equations were used calculate THR as 35%, 45% 50% reserve (HRR) 55%, 60% 65% max, results...
ObjectiveAutolysis is a physiological accommodation of bacteria to lyse themselves under stress conditions. The aim this study investigate comprehensively the autolysis lactic acid (LAB) strains stressed by various growth inhibitors. MethodsThe methods include assay LAB with origins, as well determination profiles Lactococcus lactis MG1363 conditions specified different media and inhibitors' interference. ResultsThe results showed that L. could be induced in glucose strictly-limited medium...
The humpback puffer,Tetraodon palembangensis, also known as Pao is a species of poisonous freshwater pufferfish mainly distributed in Southeast Asia (Thailand, Laos, Malaysia and Indonesia). Despite interesting biological features, such its very inactive nature, tetrodotoxin production body expansion mechanisms, molecular research on the puffer still rare because lack high-quality reference genome. Here, we reported first chromosome-level genome assembly an adult puffer, which size 362 Mb...
The humpback puffer, Tetraodon palembangensis, is a poisonous freshwater pufferfish species mainly distributed in Southeast Asia (Thailand, Laos, Malaysia and Indonesia). puffer has many interesting biological features, such as inactivity, tetrodotoxin production body expansion. Here, we report the first chromosome-level genome assembly of puffer. size 362 Mb, with contig N50 value ∼1.78 Mb scaffold ∼15.8 Mb. Based on this assembly, ∼61.5 (18.11%) repeat sequences were identified, 19,925...
The Bicolor Angelfish, Centropyge bicolor, is a tropical coral reef fish. It named for its striking two-color body. However, lack of high-quality genomic data means little known about the genome this species. Here, we present chromosome-level C. bicolor constructed using Hi-C data. assembled 650 Mbp in size, with scaffold N50 value 4.4 Mbp, and contig 114 Kbp. Protein-coding genes numbering 21,774 were annotated. Our analysis will help others to choose most appropriate de novo sequencing...
Background: Lead (Pb) is an environmental neurotoxicant which threatens human health, especially the cognitive memory in children. While its molecular basis multifactorial, growing evidence implicates epigenetic modifications Pb-mediated deficits. Methods: We utilized biology techniques, luciferase assay, miRNA profiling and quantification, immunoblots, co-immunoprecipitation, Chromatin immunoprecipitation (CHIP), lentivirus (LV)-based overexpression, Golgi-staining, behavioral tests to...