A5014369534- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Head and Neck Anomalies
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Parathyroid Disorders and Treatments
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- FOXO transcription factor regulation
- Autophagy in Disease and Therapy
- Cancer Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Radiation Dose and Imaging
- Adrenal and Paraganglionic Tumors
- Cancer Genomics and Diagnostics
- Ocular Oncology and Treatments
- Melanoma and MAPK Pathways
- Colorectal Cancer Treatments and Studies
- Cancer Risks and Factors
- Pancreatic and Hepatic Oncology Research
- Myasthenia Gravis and Thymoma
Azienda Ospedaliera Universitaria Pisana
2015-2025
University of Pisa
2016-2025
National Institute of Diabetes and Digestive and Kidney Diseases
2019
National Institutes of Health
2019
United States National Library of Medicine
2019
Institute of Experimental Endocrinology of the Slovak Academy of Sciences
2016
University College London
2015
Ospedale Cisanello
2015
Mario Negri Sud Foundation
2009-2013
University of Campania "Luigi Vanvitelli"
2011
Abstract Context The dramatic rise in the incidence of thyroid cancer over last 30 years is largely attributable to increasing diagnosis papillary microcarcinomas (mPTCs). Current guidelines endorse an observational management approach properly selected cases. Objective To evaluate feasibility active surveillance mPTC Italy, its impact on real life, and identify risk factors progression. Design setting In 2014 we started a prospective–observational study patients. Patients Included patients...
<h3>Background</h3> The <i>RET</i> proto-oncogene is responsible for the pathogenesis of hereditary (98%) and sporadic (40%) medullary thyroid carcinoma (MTC). In MTC, somatic mutations are associated with a poor prognosis. <h3>Objectives</h3> We looked at genetic profile patients advanced metastatic MTC. correlation between these outcome was also investigated. <h3>Methods</h3> 70 MTC were studied. Exons 10–11 13–16 analysed by direct sequencing. All cases studied <i>RAS</i> majority...
Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie development of hereditary medullary thyroid carcinoma (MTC). The aims this study were to evaluate prevalence in a large series MTC, collected over last 25 years, and reappraise their clinical significance. Methods: We performed genetic screening 2031 Italian subjects: patients who presented with sporadic (n = 1264) or 117) plus 650 relatives. Results: A mutation was found 115/117 (98.3%) 78/1264 (6.2%)...
Abstract Context Although the majority of RET alterations are single nucleotide variants (SNV), small deletions and/or insertions have been reported at variable prevalence. No information about efficacy RET-specific inhibitors in patients harboring indels has provided. Objective We present an update on prevalence medullary thyroid cancer (MTC) and describe selpercatinib with advanced MTC indels. Methods The tissues 287 were analyzed using Ion S5 targeted sequencing. functional role evaluated...
Anaplastic (ATC) and poorly differentiated thyroid cancer (PDTC) are very aggressive cancers whose histological diagnosis is not always straightforward. Clinical, pathological genetic features may be useful to improve the identification of these rare histotypes. In present study clinical, two groups ATC (n=21) PDTC patients were analyzed. Clinical data retrieved from a computerized database. The oncogenic profiles studied using Sanger sequencing method selected series oncogenes and/or tumor...
Summary Objective Medullary thyroid carcinoma ( MTC ) is a rare disease that can be inherited or sporadic; its pathogenesis related to activating mutations in the RET gene. Design This study describes our 20‐year experience regarding genetic screening . Patients and methods We performed 1556 subjects, 1007 with an apparently sporadic , 95 familial form 454 relatives of ‐positive patients Results A germline mutation was found 68 (6·7%) while 939 were negative for mutations. then identified...
There is much debate surrounding the choice of which patient should be submitted to postsurgical remnant radioiodine ablation (RRA), particularly in low-risk (LR) and intermediate-risk (IR) differentiated thyroid cancer (DTC).The aim this study was evaluate role postoperative high-sensitive thyroglobulin (Tg) on L-thyroxine (LT4-HSTg) neck ultrasound (US) risk restratification decision perform RRA.We evaluated 505 patients with LR or IR DTC 3 4 months after total thyroidectomy (TTx). All...
Background: Thyroglobulin (Tg) antibodies (TgAb) can interfere with Tg measurement and be used as "Tg surrogate" in patients differentiated thyroid cancer (DTC) treated total thyroidectomy (TTx) radioiodine remnant ablation (RRA). In contrast, few data, usually followed for a short-term follow-up, have been reported about the changes of TgAb levels TTx but without RRA. The aims this study were to evaluate DTC not RRA identify factors that influence these changes. Methods: change 107 (<1 cm)...
Abstract Objective Recently, several scientific societies designed ultrasound (US) risk stratification systems (RSS) to guide the workup of thyroid nodules and decide which should undergo fine-needle aspiration cytology (FNAC). However, these have been developed against papillary carcinoma, scanty data on their role in identifying medullary carcinoma (MTC) are available. The aims this study describe US features MTC evaluate performance RSS MTC. Methods Data 152 consecutive patients with was...
<b><i>Introduction:</i></b> Tyrosine kinase inhibitors represent a better treatment in patients with radioiodine-refractory differentiated thyroid cancer (RAI-R DTC). Lenvatinib is usually well-tolerated, but sometimes, it associated serious and even life-threatening side effects. The aim of this study was to evaluate the prevalence potential risk factors for fistula and/or organ perforation RAI-R DTC treated lenvatinib. <b><i>Methods:</i></b>...
Large thyroid masses, particularly if rapidly growing, are often characterized by compression and infiltration of the vital structures neck. Therefore, an early precise diagnosis, not only malignancy but also histotype, is mandatory to set up right therapy. The aim this study was evaluate diagnostic performance fine needle aspiration cytology (FNAC) core biopsy (CNB) in setting.We prospectively evaluated 95 patients with large growing masses admitted University Hospital Pisa between April...
Abstract Context The clinical response after surgery is a determinant in the management of patients with medullary thyroid carcinoma (MTC). In case excellent or structural incomplete response, follow-up strategies are well designed. Conversely, biochemical (BiR) not clearly defined. Objective This work aimed to evaluate overall and per-site prevalence disease detection sporadic MTC BiR assess predictive value various clinical, biochemical, genetic features. Methods We evaluated data 599...
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P) is an encapsulated variant of papillary carcinoma (PTC) nonaggressive clinical behavior. However, since its diagnosis exclusively possible after surgery, it represents a challenge. Neck ultrasound (US) shows good sensitivity and specificity in suggesting malignancy nodules. little information available about ability identifying NIFT-P.The aim this study was to evaluate the US NIFT-P, comparing them other...
Prostate cancer (PCa) is the second leading cause of cancer-related death in men; however, molecular mechanisms to its development and progression are not yet fully elucidated. Of note, it has been recently shown that conditional stk11 knockout mice develop atypical hyperplasia prostate intraepithelial neoplasia (PIN). We reported an inverse correlation between activity STK11/AMPK pathway MAPK/p38 cascade HIF1A-dependent malignancies. Furthermore, overactivation was detected benign...
Vandetanib is an important treatment option for advanced metastatic medullary thyroid cancer. The aims of this study were to evaluate the predictors both a longer response vandetanib and outcome. Medical records 79 cancer patients treated with at our center analysed. Twenty-five <12 months, 54 ≥12 months 24 these latter ≥48 (short-, long- very long-term). median progression free survival long long-term was significantly than in ZETA trial. When comparing groups short - only significant...