The aim of the present study was to evaluate whether tissue levels vitamin B complex and B12 were altered after crush-induced peripheral nerve injury in an experimental rat model. A total 80 male Wistar rats randomized into one control (n = 8) six groups (1, 6, 12, 24 hours, 3, 7 days injury; n 12 for each group). Crush-induced performed on sciatic nerves groups. Tissue samples from sites obtained at 1, 3 injury. Enzyme-linked immunosorbent assay results showed that injured significantly...

Crush injury to the sciatic nerve causes oxidative stress. Alfa Lipoic acid (a-LA) is a neuroprotective metabolic antioxidant. This study was designed investigate antioxidant effects of pretreatment with a-LA on crush rat nerve.Forty rats were randomized into four groups. Group I and II received saline (2 ml, intraperitoneally) (100 mg/kg, 2 in groups III IV at 24 1 hour prior injury. In II, IV, left exposed compressed for 60 seconds jeweler's forceps. (n = 10), explored but not crushed. all...

OBJECTIVE Lateral lumbar interbody fusion (LLIF) has emerged as a popular method for fusion. In this study the authors aimed to quantify biomechanical stability of an implant inserted using LLIF approach with and without various supplemental fixation methods, including interspinous plate (IP). METHODS Seven human cadaveric L2-5 specimens were tested intact in 6 instrumented conditions. The was intended be used fixation. study, however, also relative comparison these conditions follows: 1)...

Background: Low back pain is a frequent condition that results in substantial disability and causes admission of patients to neurosurgery clinics.To evaluate present the therapeutic outcomes lumbar disc hernia (LDH) treated by means conservative approach, consisting bed rest medical therapy.Methods: This retrospective cohort was carried out departments hospitals Kahramanmaraş city 23 diagnosed with LDH at levels L3-L4, L4-L5 or L5-S1 were enrolled. Results:The average age 38.4 ± 8.0 chief...

Cell‐based or magnetic field therapies as alternative approaches to pain management have been tested in several experimental models. The aim of this study therefore was investigate the actions cell‐based therapy (adipose tissue derived mesenchymal stem cells; ADMSC) pulsed (PMF) and magneto‐cell (combination ADMSC PMF) chronic constriction nerve injury model (CCI). individual (route dependent [systemic local], time‐dependent [a day a week after surgery]), PMF their combination (magneto‐cell)...

Study Design: This was a retrospective study. Objection: Lumbar Spinal Stenosis (LSS) is disease that causes chronic low back pain and can often be confused with herniated disk. In this study, deep learning-based classification model proposed to make LSS diagnosis quickly automatically an objective tool. Summary of Background Data: negative consequences such as pain, foot numbness, pain. Diagnosis difficult because it disk requires serious expertise. The shape amount stenosis are very...

Histopathological analyses were performed in ligamentum flavum (LF) hypertrophy patients with lumbar spinal stenosis (LSS) and disc herniation (LDH).The aim of the present study was to evaluate histopathological changes LF LSS LDH.LSS is most common disorder elderly patients. This condition causes lower back leg pain paresis, occurs as a result degenerative spine, including bulging intervertebral discs, bony proliferation facet joints, thickening; among these, thickening considered major...

Retrospective review.We retrospectively reviewed our patients with ankylosing spondylitis (AS) to identify their patterns of spinal fractures help clarify management strategies and the morbidity mortality rates associated this group patients.Because brittleness bone long autofused segments in AS, are common even after minor trauma often overt instability.Between January 1, 1998 March 2011, 30 (23 males, 7 females; mean age, 70.43 years; range, 45 95 years) radiographic diagnosis AS column...

In Brief Study Design. Oxidative/nitrosative stress in vertebral endplates of patients with low back pain and Modic changes (MCs) (types I, II, III) endplate on magnetic resonance imaging. Objective. The aim this study was to assess the levels oxidative/nitrosative biomarkers MCs. Summary Background Data. Degenerated discs abnormalities is postulated as a possible source pain. plays an important role various human diseases. However, presence has not been studied Methods. Patients MCI, III (n...

Clinical chronic neuropathic pain is often resistant to currently used pharmacotherapeutic applications. A number studies have shown that pulsed magnetic field (PMF) application may ameliorate the associated with damages, surgeries or diseases. However, possible potential mechanisms of PMF treatments not been well documented. This study aimed assess therapeutic effects treatment on a Chronic Constriction Injury model (CCI) which mimics clinical symptoms.Effects sham (SPMF) were investigated...

a b s t r c tOs odontoideum is separate odontoid process from the body of axis.It most common anomaly process.Patients with this condition can be asymptomatic or present wide range neurological dysfunctions.It may cause cervical instability, atlantoaxial dislocation and myelopathy.This mimic Type I II fractures.There role for conservative treatment an incidentally found, radiologically stable non-compressive os odontoideum.However, surgical has definitive in symptomatic cases.In study, case...

Our aim was to evaluate the histopathological effects of tissue adhesives on peripheral nerve regeneration after experimental sciatic transection in rats and search whether these may possess a therapeutic potential injuries.This study performed using 42 female Wistar-Albino distributed 6 groups subsequent right nerves. Group I underwent external circumferential neurolysis; II received suture repair; III had local polymeric hydrogel based adhesive administration; IV repair application...

This study was performed to evaluate and compare the efficacies of caudal epidural injections at prone lateral decubitus positions.A total 120 patients suffering from low back pain radicular leg were included randomly distributed into 2 groups according position during injection. In Group 1 (n=60; 32 women, 28 men), injection position, whereas it implemented in 33 27 men). Visual analogue scale, Oswestry Disability Index (ODI), walking tolerance (WT) standing (ST) compared before after...

OBJECTIVE: To investigate the histopathological and biochemical effects of topical systemic administrations erythropoietin (EPO) on crush transection type peripheral nerve injuries in an experimental rat model.METHODS: 128 male Wistar-Albino rats were allocated to 8 groups according route administration EPO (local/systemic) injury (crush/transection). compared with respect examination number axons as well levels IL-1β, IL-6, IL-10.RESULTS: Groups receiving either locally or intraperitoneally...

Background context: Synergy disc is a new cervical prosthesis that incorporates alignment restoration while providing full intervertebral kinematics.Purpose: This follow-up study with 40 Disc patients 24-month compared changes retrospective cohort of 30 single level anterior discectomy and fusion (ACDF) patients.Study design/setting: The pilot trial was multi-center, prospective, consecutive patient enrollment using the for treatment two-level degenerative disease spine.Patient sample:...

Background Context: For cervical disc replacements to be comparable the gold standard of discectomy and fusion (ACDF), they must able provide normal range motion as well predictable reliable correction alignment. The Synergy Disc was designed alignment in sagittal plane while restoring physiologic motion. Purpose: This study evaluated whether provided preservation and/or restoration normalizing kinematics providing acceptable clinical outcomes. by compared with a retrospective cohort 30...