A5013907456- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- COVID-19 epidemiological studies
- Bacterial Infections and Vaccines
- Data Stream Mining Techniques
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Atmospheric and Environmental Gas Dynamics
- Advanced Causal Inference Techniques
- Viral Infections and Outbreaks Research
- Evolution and Genetic Dynamics
- Animal Disease Management and Epidemiology
- COVID-19 Clinical Research Studies
- Per- and polyfluoroalkyl substances research
- Evolutionary Game Theory and Cooperation
- Hepatitis Viruses Studies and Epidemiology
- Advanced Bandit Algorithms Research
- Reinforcement Learning in Robotics
- Animal Virus Infections Studies
- Toxic Organic Pollutants Impact
Swiss Tropical and Public Health Institute
2023-2025
University of Basel
2023-2025
University of New Haven
2021-2023
Yale University
2021-2023
Health First
2023
University of Turin
2021
Institute for Scientific Interchange
2021
With the evidence of waning immunity mRNA vaccine BNT162b2 (Pfizer-BioNTech), a nationwide third-dose (booster) vaccination campaign was initiated in Israel during August 2021; other countries have begun to administer booster shot as well.To evaluate initial short-term additional benefit 3-dose vs 2-dose regimen against infection SARS-CoV-2.This preliminary retrospective case-control study used 2 complementary approaches: test-negative design and matched design. Participants were included...
The effectiveness of vaccines against COVID-19 on the individual level is well established. However, few studies have examined vaccine transmission. We used a chain binomial model to estimate vaccination with BNT162b2 [Pfizer-BioNTech messenger RNA (mRNA)-based vaccine] household transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Israel before and after emergence B.1.617.2 (Delta) variant. Vaccination reduced susceptibility infection by 89.4% [95% confidence...
Abstract The individual-level effectiveness of vaccines against clinical disease caused by SARS-CoV-2 is well-established. However, few studies have directly examined the effect COVID-19 on transmission. We quantified vaccination with BNT162b2 (Pfizer-BioNTech mRNA-based vaccine) household transmission in Israel. fit two time-to-event models – a mechanistic model and regression to estimate vaccine susceptibility infection infectiousness given settings. Vaccine was 80-88%. For breakthrough...
The short-term effectiveness of a two-dose regimen the BioNTech/Pfizer mRNA BNT162b2 vaccine for adolescents has been demonstrated. However, little is known about long-term in this age group. It known, though, that waning vaccine-induced immunity against infection adult populations evident within few months.
Per- and polyfluoroalkyl substances (PFASs) are a class of toxic organic compounds that have been widely used in consumer applications industrial activities, including oil gas production. We measured PFAS concentrations 45 private wells 8 surface water sources the gas-producing Doddridge, Marshall, Ritchie, Tyler, Wetzel Counties northern West Virginia investigated relationships between potential drinking receptors. All samples 60% sampled contained quantifiable levels at least one targeted...
The short-term effectiveness of a 2-dose regimen the BioNTech/Pfizer BNT162b2 vaccine for adolescents has been demonstrated. However, little is known about long-term in this age group. It known, however, that waning vaccine-induced immunity against infection adult populations evident within few months.
Abstract With the evidence of waning immunity BNT162b2 vaccine, a national third dose vaccination campaign was initiated in Israel during August 2021; other countries have announced their intention to administer booster shot as well. Leveraging data from Maccabi Healthcare Services, we conducted preliminary retrospective study aimed at evaluating initial short-term effectiveness three versus two regimen against infection due Delta variant SARS-CoV-2, using complementary approaches;...
Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect mortality among older age groups. This multicountry study aimed to assess the population-level impact of pediatric PCVs all-cause pneumonia children ≥5 years age, and invasive pneumococcal disease (IPD) cases Chile.
Invasive meningococcal disease (IMD) has a low and unpredictable incidence, presenting challenges for real-world evaluations of vaccines. Traditionally, vaccine impact is evaluated by predicting counterfactuals from pre-immunization IMD incidences, possibly controlling in unvaccinated age groups, but the selection controls can influence results. We retrospectively applied synthetic control (SC) method, previously used pneumococcal disease, to data 2 programs immunization infants against...
Abstract Background To achieve licensure, interventions typically must demonstrate efficacy against a primary outcome in randomized clinical trial. However, selecting single priori is challenging. Incorporating data from multiple and related outcomes might help to increase statistical power trials. Inspired by real-world trials of respiratory syncytial virus (RSV), we examined methods for analyzing on endpoints. Method We simulated three different populations which the intervention...
To meet regulatory approval, interventions must demonstrate efficacy against a primary outcome in randomized clinical trials. However, when there are multiple clinically relevant outcomes, selecting single is challenging. Incorporating data from outcomes may increase statistical power We examined methods for analyzing on endpoints, inspired by real-world trials of respiratory syncytial virus (RSV).We developed novel permutation test representing weighted average individual statistics ( wavP...
Abstract Background The relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Streptococcus pneumoniae remains uncertain. This study investigates the association routine pneumococcal vaccination progression to COVID-19 outcomes in a cohort of older adults United States. Methods Our includes aged 65 from subset covered by Medicare States with documented diagnosis. Logistic regression models were employed assess (13-valent conjugate vaccine [PCV13] 23-valent...
A meeting held in Lisbon, Portugal, February 2023 focused on critical aspects of clinical trial design for respiratory syncytial virus (RSV) preventative therapies. The addressed two primary areas: enhancing the efficiency and success randomized controlled trials (RCTs) RSV therapies designing RCTs to better inform post-licensure decision-making. Topics included selection endpoints, innovative approaches incorporating multiple endpoints historical data, challenges benefits sequential...
Abstract Mobile testing services provide opportunities for active surveillance of infectious diseases hard-to-reach and/or high-risk individuals who do not know their disease status. Identifying as many infected possible is important mitigating transmission. Recently, multi-armed bandit sampling approaches have been adapted and applied in this setting to maximize the cumulative number positive tests collected over time. However, these algorithms considered possibility variability...
The efficacy of the four-component 4CMenB vaccine is measured through serum bactericidal antibody (SBA) assay on four meningococcal B (MenB) indicator strains. However, they are not epidemiologically relevant for disease, thus real-world persistence protection remains uncertain. Several mathematical models waning immunity were fitted longitudinal SBA data from studies in adolescents, with up to eight years follow-up after priming vaccination. best model was used predict MenB typing United...
Abstract Background Pneumococcal conjugate vaccines (PCVs) provide strong direct protection in children, while limited data are available on their indirect effect mortality among older age groups. This multi-country study aimed to assess the population-level impact of pediatric PCVs all-cause pneumonia ≥5 years age, and invasive pneumococcal disease (IPD) cases Chile. Methods Demographic from Argentina, Brazil, Chile, Colombia, Mexico were collected for various strata considering ≥...
Multi-strain competition on networks is observed in many contexts, including infectious disease ecology, information dissemination or behavioral adaptation to epidemics. Despite a substantial body of research has been developed considering static, time-aggregated networks, it remains challenge understand the transmission concurrent strains when links network are created and destroyed over time. Here we analyze how dynamics shapes outcome between an initially endemic strain emerging one, both...