A5015146705- Cerebrospinal fluid and hydrocephalus
- Genetics and Neurodevelopmental Disorders
- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Infectious Encephalopathies and Encephalitis
- Intracranial Aneurysms: Treatment and Complications
- Cancer-related Molecular Pathways
- Epilepsy research and treatment
- Liver physiology and pathology
- EEG and Brain-Computer Interfaces
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Lipid Membrane Structure and Behavior
- Metabolism and Genetic Disorders
- Cellular transport and secretion
- Vascular Malformations Diagnosis and Treatment
University of California, San Francisco
2020-2025
Pediatrics and Genetics
2025
UCSF Benioff Children's Hospital
2022-2023
Epilepsy Foundation
2021
Cancer Research UK Scotland Institute
1997
Switch
1997
Electroencephalography (EEG) remains underutilized for stroke characterization. We sought to assess the performance of EEG Correlate Of Injury Nervous system (COIN) index, a quantitative metric designed recognition in children, discriminating large from small ischemic strokes adults. Retrospective, single-center cohort adults with acute (within 7 days) who underwent at least 8 hours continuous monitoring hospital. Stroke size was categorized as or based on threshold 100 mL using ABC/2...
PCDH19 is a common epilepsy gene causing medication resistant with fever-related seizures. Traditionally, patients PCDH19-related have not been considered surgical candidates. This retrospective review evaluated three pathogenic variants in who presented seizures childhood, had one seizure semiology, became resistant, and concordant imaging, semiology electrographic findings. All ultimately underwent temporal lobectomy, resulting freedom. These findings suggest surgery can be an effective...
Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic vesicle-associated membrane protein 2 (VAMP2) reveal common global developmental delay, autistic tendencies, behavioral disturbances, a higher propensity to develop epilepsy. For one patient, cognitively impaired adolescent stop-gain VAMP2 mutation, we tested potential treatment strategy, enhancing neurotransmission by prolonging action potentials aminopyridine family potassium channel...
BackgroundAlthough seizures in neonates are common and often due to acute brain injury, 10-15% unprovoked from congenital malformations. A better understanding of the risk neonatal-onset epilepsy by type malformation is essential for counseling monitoring.MethodsIn this retrospective cohort study, we evaluated 132 with malformations their epilepsy. Malformations were classified into one five categories based on imaging patterns prenatal or postnatal imaging. Infants monitored continuous...