A5035304800- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic Alkyne Reactions
- Catalytic C–H Functionalization Methods
- Crystallography and molecular interactions
- Synthetic Organic Chemistry Methods
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Traditional and Medicinal Uses of Annonaceae
- Venous Thromboembolism Diagnosis and Management
- Amino Acid Enzymes and Metabolism
- Diagnosis and Treatment of Venous Diseases
- Radical Photochemical Reactions
- Cyclization and Aryne Chemistry
- Ultrasound and Cavitation Phenomena
- Click Chemistry and Applications
- Synthesis and Catalytic Reactions
- Biomedical Research and Pathophysiology
- Catalysis and Hydrodesulfurization Studies
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Organometallic Complex Synthesis and Catalysis
- Cardiac, Anesthesia and Surgical Outcomes
- Entomological Studies and Ecology
- Renaissance and Early Modern Studies
Federico II University Hospital
2024
University of Naples Federico II
2022
University of Florence
2017-2021
Institut Català d'Investigació Química
2021
University of Oxford
2017
Science Oxford
2017
Indenes constitute an important class of molecules which continue to attract interest from the synthetic organic chemists′ community because not only many natural and compounds embodying indene skeleton display bioactivity or pharmaceutical activity but also indenes find applications in material science, e.g. photovoltaic solar cells preparation new fluorescent materials, metal complexes with special catalytic activity. Many approaches have been exploited last four years build this bicyclic...
Chiral gold(I)-cavitand complexes have been developed for the enantioselective alkoxycyclization of 1,6-enynes. This cyclization has applied first total synthesis carbazole alkaloid (+)-mafaicheenamine C and its enantiomer, establishing configuration as R. The cavity effect was also evaluated in cycloisomerization dienynes. A combination experiments theoretical studies demonstrates that gold(I) forces enynes to adopt constrained conformations, which results high observed regio- stereoselectivities.
The tandem gold(I)-catalyzed propargyl Claisen rearrangement/Nazarov cyclization of vinyl ether derivatives, followed by in situ reduction the resulting carbonyl group, provides functionalized cyclopentadienes fused with various N-hetero- and carbacycles, including indoles, good to excellent yields. reaction occurs high regioselectivity, position double bonds five-membered ring depending on type (hetero)cycle bearing propargylic moiety side chain latter.
The tandem gold(I)-catalyzed propargyl Claisen rearrangement/hydroarylation reaction of suitable vinyl ethers, followed by in situ reduction the resulting carbonyl group, provides functionalized indenes good to excellent yields. occurs at room temperature dichloromethane presence 3 mol % [IPrAuCl]/AgBF4 as best catalytic system. Instead, cyclization allene intermediate either does not take place or is very slow with phosphine ligands. A variety substituents and functional groups present on...
Abstract Chiral gold(I)‐cavitand complexes have been developed for the enantioselective alkoxycyclization of 1,6‐enynes. This cyclization has applied first total synthesis carbazole alkaloid (+)‐mafaicheenamine C and its enantiomer, establishing configuration as R. The cavity effect was also evaluated in cycloisomerization dienynes. A combination experiments theoretical studies demonstrates that gold(I) forces enynes to adopt constrained conformations, which results high observed regio‐...
A novel α-alkylation of <italic>N</italic>-diphenylphosphinoyl ketimines with α-bromocarbonyl compounds has been accomplished under mild conditions using nickel and ruthenium light-promoted catalysis.
An efficient synthetic approach to the tricyclic 1,7a-dihydro-1,3a-ethano-indene and 1,8a-dihydro-1,3a-ethano-azulene skeletons from suitable propargyl vinyl ethers is based on a one-pot, multistep process entailing gold(I)-catalyzed Claisen rearrangement/Nazarov cyclization, [4+2] cycloaddition of formed six- or seven-membered ring-fused cyclopentadiene system, final protection step for easy isolation purification products by chromatography.
Abstract The synthesis of (±)‐ epi ‐jungianol was successfully carried out by the gold(I)‐catalyzed propargyl Claisen rearrangement/hydroarylation cascade reaction suitably substituted vinyl ethers as key step to form indane skeleton. Two routes were compared, which involved substrates with a different degree substitution on moiety. one based ether bearing an unsubstituted moiety, despite entailing two additional steps, provided final compound in higher overall yield. A method for...
Background. Vasoactive drugs are considered an important therapeutic tool in managing phlebolymphologic disease. The current study was performed to evaluate the results of a high-dose diosmin-based combination (Venoplant 2g) symptomatic patients with chronic venous disease (CVD), treated endovascular surgery, regarding efficacy this treatment and clinical signs patients’ compliance. Methods: We identified, between April 2022 March 2023, 50 CVD who underwent endovenous ablation additionally...