A5003719618- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Nanoparticles: synthesis and applications
- Laser-Ablation Synthesis of Nanoparticles
- Conducting polymers and applications
- 3D Printing in Biomedical Research
- Polymer Surface Interaction Studies
- Cellular Mechanics and Interactions
- Wound Healing and Treatments
McGill University
2016-2022
Implants can induce a foreign body reaction that leads to chronic inflammation and fibrosis in the surrounding tissue. Macrophages help detect material, play role inflammatory response, may promote instead of desired tissue regeneration around implants. Implant surface properties impact macrophage responses by changing nature adsorbed protein layer, but conflicting studies highlight complexity this relationship. In study, effect chemistry on behavior was investigated with poly(styrene)...
Poly(etheretherketone) (PEEK) implants suffer from poor osseointegration because of chronic inflammation. In this study, we hypothesized that adding NH2 and COOH groups to the surface PEEK could modulate macrophage responses by altering protein adsorption improve its osseointegration. COOH-functionalized surfaces induced pro- anti-inflammatory responses, respectively, differences in patterns on these were related varied inflammatory responses. The significantly reduced osteogenic...
Electrospun fibers are excellent candidates for wound dressings and tissue engineering scaffolds. To actively prevent infection during healing, the electrospun can be loaded with antimicrobial agents, such as antibiotics or natural antimicrobials. Different methods have been used to incorporate agents in electrospinning process, including blending, coaxial electrospinning, emulsion provide controlled release of agent. Some evidence suggests that a burst antimicrobials through physical...
Nacre has an excellent combination of strength and toughness due to its "brick-and-mortar" layered structure. Graphene oxide (GO) is ideal candidate as a "brick" material two-dimensional structure, outstanding ultimate strength, Young's modulus. GO also able stimulate osteogenesis, which suggests the potential application nacre-like GO-based nanocomposites in bone regeneration. Most developed thus far focus on simultaneous enhancement toughness, with only three studies published date...
Objectives Scaffolds for bone tissue engineering (BTE) are three-dimensional (3D) porous matrices that provide the necessary sites cell adhesion and proliferation, where architecture plays an important role. Ideally, BTE scaffolds should have interconnected network of both large small pores to facilitate infiltration cells diffusion growth factors nutrients 1 . also enhance osteogenic differentiation improve regeneration. Graphene oxide (GO) can promote mesenchymal stem (MSCs) because it...