A5064020619- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Management of metastatic bone disease
- Radiation Detection and Scintillator Technologies
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Advanced X-ray and CT Imaging
- Plant Diversity and Evolution
- Advances in Oncology and Radiotherapy
- Gastric Cancer Management and Outcomes
- Nonmelanoma Skin Cancer Studies
- Taxation and Legal Issues
- Pancreatic and Hepatic Oncology Research
- European and International Law Studies
- Plant and Biological Electrophysiology Studies
- Head and Neck Surgical Oncology
- Discrimination and Equality Law
- Breast Cancer Treatment Studies
Aspirus Wausau Hospital
2019-2022
Erasmus MC
2021
University of Wisconsin–Madison
2007-2019
UW Health University Hospital
2015-2019
University of Wisconsin Carbone Cancer Center
2019
Aspirus
2018
Wentworth Douglass Hospital
2018
University of Pennsylvania
2018
Wisconsin Institutes for Discovery
2015
Clackamas Radiation Oncology Center
2009
Magnetic resonance-guided radiation therapy (MRgRT) offers advantages for image guidance radiotherapy treatments as compared to conventional computed tomography (CT)-based modalities. The superior soft tissue contrast of magnetic resonance (MR) enables an improved visualization the gross tumor and adjacent normal tissues in treatment abdominal thoracic malignancies. Online adaptive capabilities, coupled with advanced motion management real-time tracking tumor, directly allow high-precision...
The American Association of Physicists in Medicine (AAPM) is a nonprofit professional society whose primary purposes are to advance the science, education, and practice medical physics. AAPM has more than 8000 members principal organization physicists United States. will periodically define new guidelines for physics help science improve quality service patients throughout Existing be reviewed purpose revision or renewal, as appropriate, on their fifth anniversary sooner. Each guideline...
Several groups are exploring the integration of magnetic resonance (MR) image guidance with radiotherapy to reduce tumor position uncertainty during photon radiotherapy. The therapeutic gain from reducing using intrafraction MR imaging could be partially offset if negative effects field-induced dose perturbations not appreciated or accounted for. authors hypothesize that a more rotationally symmetric modality such as helical tomotherapy will permit systematic mediation these perturbations....
This work describes a novel application of MR-guided online adaptive radiotherapy (MRgoART) in the management patients whom urgent palliative care is indicated using statum-adaptive (STAT-ART). The implementation STAT-ART, as performed at our institution, presented including discussion advantages and limitations compared to standard for on conventional c-arm linacs. MR-based treatment planning techniques STAT-ART density overrides deformable image registration (DIR) diagnostic CT MR are also...
Purpose: The Caribbean Radiation Oncology Center acquired a DELTA4 ® diode phantom for helical tomotherapy IMRT QA and presents the results of their first 264 clinical cases. Methods: validation consisted several case studies comparing existing ionization chamber Gafchromic film to results, along with longitudinal study analyzing against other machine procedures complete sample patients. Results: resulted in maximum observed difference 0.7% between measurements low dose‐gradient regions....
The dosimetric stability of six TomoTherapy units was analyzed to investigate changes in performance over time and with system upgrades. Energy output were tracked using monitor chamber signal, onboard megavoltage computed tomography (MVCT) detector profile, external ion measurements. systems (and monitoring periods) include three Hi-Art (67, 61, 65 mos.), two TomoHDA (31 26 one Radixact unit (11 representing approximately 10 years clinical use. four newest use the Dose Control Stability...
Purpose: Magnetic resonance imaging–guided radiation therapy has entered clinical practice at several major treatment centers. Treatment of early-stage non-small cell lung cancer with stereotactic body is one potential application this modality, as some form respiratory motion management important to address. We hypothesize that magnetic tri-cobalt-60 can be used generate clinically acceptable plans. Here, we report on a dosimetric comparison between plans and internal target volume–based...
The multi-leaf collimator (MLC) assembly present on TomoTherapy (Accuray, Madison WI) radiation therapy (RT) and mega voltage CT machines is well suited to perform fluence field modulated (FFMCT). In addition, there a demand in the RT environment for FFMCT imaging techniques, specifically volume of interest (VOI) imaging. A clinical machine was programmed VOI. Four different size ROIs were placed at varying distances from isocenter. Projections intersecting VOI received 'full dose' while...
Purpose The aim of this study was to validate the accuracy an exit detector‐based dose reconstruction tool for helical tomotherapy ( HT ) delivery quality assurance DQA ). Methods and material Exit developed patient‐specific treatment verification. performs a on planning image using sinogram measured by detector with no objects in beam (i.e., static couch), compares reconstructed planned dose. Vendor supplied (three “TomoPhant”) plans cylindrical solid water (“cheese”) phantom were used...
It was previously demonstrated that dose delivered by a conventional linear accelerator using IMRT or VMAT can be reconstructed — on patient phantom datasets helical diode array measurements and technique called planned perturbation (PDP). This allows meaningful intuitive analysis of the agreement between dose, including direct comparison dose-volume histograms. While conceptually similar to modulated arc techniques, tomotherapy introduces significant challenges PDP formalism, arising...
The capability of the TrueBeam treatment system to deliver step and shoot IMRT plans at low dose rates was evaluated. Beam characteristics during (5 100 MU/min) were evaluated for consistency using a planar ion chamber array. MU constancy, linearity, beam profile symmetry all found be equivalent within 0.5%. response Scandi Dos Delta 4 also static open beams compared measurements, comparing 5 - 20 MU/min rates, with maximum observed absolute difference 0.8% equivalence margin 0.2%. Gamma...
Conclusion:The results indicate the feasibility of VMAT treatments under tumor tracking for selected patients.The arcs available planning influence quality treatment.The L partial arc plans had clinically acceptable in four patients.Treatments with reduced margins could be safely delivered by gating treatment beam if motion exceeds margins.Also, a great advantage is that dose to exactly monitored.
The question of the legal competence EU to adopt binding measures assist in combatting racial discrimination has traditionally not received much attention. Treaty on European Union does include a general prohibition but only (pay related) sex discrimination. Moreover, provision outlawing grounds nationality generally been interpreted as limited between nationals Member States. For rest, if anything, provisions actually reinforce unequal treatment situation migrants with State and ‘third...
Purpose: This work presents a new approach that uses the multi leaf collimator present on TomoTherapy devices to modulate imaging beam. allows for targeted in which only regions of clinical importance IGRT (patient positioning confirmation) receive high level image quality. total dose decrease, especially healthy tissue. Methods: A machine was programmed deliver such small pre‐defined volumes interest (VOI) received relatively higher levels quality with respect surrounding regions. Four...
Purpose: Dose limiting structures, such as the duodenum, render treatment of pancreatic cancer challenging. In this multi-institutional study, we assess dosimetric differences caused by interfraction pancreas-to-duodenum motion using MR-IGRT to determine potential impact adaptive replanning. Methods: Ten patients from two institutions undergoing MRI-guided radiotherapy with conventional fractionation (n=5) or SBRT for were included. Initial plans limited duodenal dose constraints 50 Gy (0.5...
Purpose: Pulsed reduced dose‐rate radiotherapy (PRDR) is a technique used for treatment of recurrent disease where planned split into 0.2 Gy pulses, each separated by three‐minute intervals, to achieve time averaged dose rate 0.0667 Gy/min. This study investigated the feasibility using TomoTherapy's fixed angle delivery feature (TomoDirect) create high quality IMRT plans that meet radiobiological constraints PRDR. Methods: Two (one craniospinal irradiation and complex shaped temporal lobe...
Purpose: To develop a combined simulation and treatment workflow for MRI‐guided radiation therapy using the ViewRay planning delivery system. Methods: Several features of MRIdian workflows are used to simulate treat patients that require emergent radiotherapy. A simple “pre‐plan” is created on diagnostic imaging retrieved from radiology PACS, where conformal fields target volume defined by physician based review images chart notes. After initial consult in oncology, patient brought room,...