A5027017857- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Advanced MRI Techniques and Applications
- Magnetic confinement fusion research
- Plasma Diagnostics and Applications
- Radiation Detection and Scintillator Technologies
- Radiomics and Machine Learning in Medical Imaging
- Laser Design and Applications
- Laser-induced spectroscopy and plasma
- Ocular Oncology and Treatments
- Retinal and Macular Surgery
- Electrokinetic Soil Remediation Techniques
- Landfill Environmental Impact Studies
- Diabetes Management and Education
- Radiopharmaceutical Chemistry and Applications
- Health Promotion and Cardiovascular Prevention
- Ocular Infections and Treatments
- Ionosphere and magnetosphere dynamics
- Laser-Plasma Interactions and Diagnostics
- Medical Imaging and Analysis
- Glioma Diagnosis and Treatment
- Solid State Laser Technologies
- Radiation Dose and Imaging
- Radiation Effects and Dosimetry
Affiliated Hospital of North Sichuan Medical College
2024
University of California, Los Angeles
2017-2020
Stanford University
2020
University of Wisconsin–Madison
2010-2018
Wisconsin Institutes for Discovery
2015-2018
Varian Medical Systems (United States)
2015
Qujing Normal University
2011
UPMC Hillman Cancer Center
2006
This work describes the development and validation of a patient-specific Monte Carlo internal dosimetry platform called RAPID (Radiopharmaceutical Assessment Platform for Internal Dosimetry). utilizes serial PET/CT or SPECT/CT images to calculate voxelized three-dimensional (3D) dose distributions with code Geant4. RAPID's calculations were benchmarked against previously published S-values specific absorbed fractions (SAFs) calculated monoenergetic photon electron sources within Zubal...
Using the graphical processing units (GPU) hardware technology, an extremely fast Monte Carlo (MC) code ARCHERRT is developed for radiation dose calculations in therapy. This paper describes detailed software development and testing three clinical TomoTherapy® cases: prostate, lung, head & neck.To obtain clinically relevant distributions, phase space files (PSFs) created from optimized therapy treatment plan fluence maps were used as input to ARCHERRT. Patient-specific phantoms constructed...
Emerging magnetic resonance (MR) guided radiotherapy affords significantly improved anatomy visualization and, subsequently, more effective personalized treatment. The new therapy paradigm imposes significant demands on radiation dose calculation quality and speed, creating an unmet need for the acceleration of Monte Carlo (MC) calculation. Existing deep learning approaches to denoise final plan MC fail achieve accuracy speed requirements large-scale beamlet in presence a strong field online...
Two standard commercial flashlamp-pumped Nd:YAG (YAG denotes yttrium aluminum garnet) lasers have been upgraded to "pulse-burst" capability. Each laser produces a burst of up 15 2 J Q-switched pulses (1064 nm) at repetition rates 1-12.5 kHz. Variable pulse-width drive (0.15-0.39 ms) the flashlamps is accomplished by insulated gate bipolar transistor (IGBT) switching electrolytic capacitor banks. Direct control Pockels cell enables optimal pulse energy extraction, and four during one...
The impact of α and β radiation on antioxidant depletion in smooth high-density polyethylene (HDPE) geomembranes (GMs) is described. Smooth HDPE GMs having different thickness (0.04-mm, 0.1-mm, 0.2-mm) were created by mechanically pulverizing sections 2-mm-thick GM extruding the polymer at thicknesses using a film blowing machine. was also used experiments. specimens exposed to sealed sources 241Am 99Tc for 1–50 h simulate from U low-level radioactive waste (LLW) leachate. Standard oxidative...
Several groups are exploring the integration of magnetic resonance (MR) image guidance with radiotherapy to reduce tumor position uncertainty during photon radiotherapy. The therapeutic gain from reducing using intrafraction MR imaging could be partially offset if negative effects field-induced dose perturbations not appreciated or accounted for. authors hypothesize that a more rotationally symmetric modality such as helical tomotherapy will permit systematic mediation these perturbations....
4D cone beam computed tomography (CBCT) images of the thorax and abdomen can have reduced quality due to limited number projections per respiratory bin used in gated image reconstruction. In this work, we present a new algorithm reconstruct high CBCT by simultaneously reconstructing generating an associated motion model. This is done updating model parameters compensate for during iterative reconstruction process. acquisition was simulated using digital eXternal CArdiac Torso (XCAT) phantom,...
Background Type 2 diabetes(T2DM) is a global health problem which accompanied with multi-systemic complications, and associated long-term burden economic burden. Effective seeking behavior (HSB) refers to reasonably utilize resources, effectively prevent treat diseases, maintain health. vital mitigate the risk of T2DM complications. However, for patients remains sub-optimal worldwide. Objective The study aimed explore internal logic how develops influencing factors behavior. With view...
Following the proposal by several groups to integrate magnetic resonance imaging (MRI) with radiation therapy, much attention has been afforded examining impact of strong (on order a Tesla) transverse fields on photon dose distributions. The effect field distributions must be considered in take full advantage benefits real-time intra-fraction imaging. In this investigation, we compared handling particle transport between two Monte Carlo codes, EGSnrc and Geant4, analyze various aspects their...
By manipulating magnetic reconnection in Madison Symmetric Torus (MST) discharges, we have generated and confined for the first time a reversed-field pinch (RFP) plasma with an ion temperature >1 keV electron of 2 keV. This is achieved at toroidal current about 0.5 MA, approaching MST's present maximum. The manipulation begins intensification discrete events, causing to increase several kiloelectronvolts. then quickly suppressed inductive profile control, leading capture portion added heat...
Two standard commercial flashlamp-pumped Nd:YAG lasers have been upgraded to "pulse-burst" capability. Each laser produces a burst of up fifteen 2 J Q-switched pulses (1064 nm) at repetition rates 1–12.5 kHz. Variable pulse-width drive (0.15–0.39 ms) the flashlamps is accomplished by IGBT (insulated gate bipolar transistor) switching electrolytic capacitor banks. Direct control Pockels cell enables optimal pulse energy extraction, and four during one flashlamp pulse. These are used in...
Dose calculation is one of the most computationally intensive, yet essential tasks in treatment planning process. With recent interest automatic beam orientation and arc trajectory optimization techniques, there a great need for more efficient model-based dose algorithms that can accommodate hundreds to thousands candidates at once. Foundational work has shown translation graphical processing units (GPUs), lending remarkable gains efficiency. But these methods provide parallelization only...
Purpose Episcleral eye plaques provide excellent local control of ocular melanoma, but vision sparing remains a significant problem with 30% or more patients experiencing visual acuity degradation. The use silicone oil shielding Iodine‐125 has previously been reported to improve critical structure sparing. We hypothesized that the Palladium‐103 would effectiveness due strong energy dependence photoelectric effect. This Monte Carlo simulation study reports comparison effects when used in...
Purpose: The future of radiation therapy will require advanced inverse planning solutions to support single‐arc, multiple‐arc, and “4 π ” delivery modes, which present unique challenges in finding an optimal treatment plan over a vast search space, while still preserving dosimetric accuracy. successful clinical implementation such methods would benefit from Monte Carlo (MC) based dose calculation methods, can offer improvements accuracy when compared deterministic methods. standard method...
Purpose: To demonstrate real-time dose calculation of free-breathing MRI guided Co−60 treatments, using a motion model and Monte-Carlo to accurately account for the interplay between irregular breathing an IMRT delivery. Methods: ViewRay Co-60 distributions were optimized on ITVs contoured from CT images lung cancer patients. Each treatment plan was separated into 0.25s segments, accounting MLC positions beam angles at each time point. A voxel-specific derived multiple fast-helical CTs...
Purpose: Magnetic resonance image-guided radiotherapy (MR-IGRT) has emerged as a promising new technology to reduce tumor position uncertainty during photon treatments of lung cancer. MRIGRT improves upon traditional IGRT techniques by providing real-time intrafraction imaging motion. However, the use MRI beam delivery complicates treatment planning since magnetic field will perturb radiation dose distribution especially in fields prescribed heterogeneous regions body such lung. In this...
Purpose: The development of novel agents for targeted radionuclide therapy has led to an important need accurate dosimetry characterization during pre-clinical trials. purpose this study is discuss our progress in developing a fully automated Monte Carlo-based platform external and/or internal absorbed dose quantification small animals. Methods: was built entirely around the Carlo code Geant4 version 9.3. CT and PET image datasets mouse injected with CLR1404, tumor target pharmaceutical that...
Internal time-resolved measurement of magnetic field and electron temperature in low-field (≤ 1 T) plasmas is a difficult diagnostic challenge. To meet this challenge the Madison Symmetric Torus reversed-field pinch, two techniques are being developed: 1) spectral motional Stark effect (MSE) 2) Fast Thomson scattering. For MSE, entire Stark-split Hα spectrum emitted by hydrogen neutral beam atoms recorded analyzed using newly refined atomic emission model. A new analysis scheme has been...
Purpose: The advent of on‐line/off‐line adaptive, and biologically‐conformal radiation therapy has led to a need for treatment planning solutions that utilize voxel‐specific penalties, requiring optimization over large solution space is performed quickly, the dose in each voxel calculated accurately. This work proposes “passive” framework, which executed concurrently during Monte Carlo calculation, evaluating cost/benefit history transport, creates passively optimized fluence map. Methods:...
Purpose: As a module of ARCHER ‐‐ Accelerated Radiation‐transport Computations in Heterogeneous EnviRonments, RT is designed for RadioTherapy (RT) dose calculation. This paper describes the application ARCHERRT on patient‐dependent TomoTherapy and patient‐independent IMRT. It also conducts “fair” comparison different GPUs multicore CPU. Methods: The source input used phase space file (PSF) generated from optimized plan. For IMRT, open filed PSF cases. intensity modulation simulated by...
Purpose: To enable a treatment planning solution that utilizes voxel‐specific penalties requires optimizing over large space both quickly and accurately. Although challenging, such methods will enhance the clinical impact of adaptive (online offline) biologically guided radiotherapy. Monte Carlo calculations generally provide improved accuracy deterministic methods, but with increased computation time. Instead, we present low memory footprint direct optimization platform optimizes fluence...
Conventional genetic algorithm is prone to many problems, such as premature convergence, poor performance of partial search, inefficient in the final stage, difficulty keeping balance between population diversity and selective pressure. In order resolve these amount information from parents was measured with correlation coefficient. Then an alternation strategy based on hereditary presented, which not only guaranteed diversity, but provided support for searching optimum solution. Adaptive...
Purpose: There is growing excitement over new treatment modalities that integrate magnetic resonance (MR) image guidance with radiotherapy delivery systems. The therapeutic gain from reducing tumor position uncertainty using intra‐fraction MR imaging during will only be achieved by adequately accounting for impact of the field on dose distributions delivery. We propose integrating MR‐image a more rotationally symmetric modality such as helical Tomotherapy might reduce or even eliminate...
Purpose: Magnetic resonance image‐guided radiotherapy (MRIgRT) has emerged as a promising new technology to reduce tumor position uncertainty during photon radiotherapy. The use of MRI beam delivery complicates treatment planning since the magnetic field will perturb radiation dose distribution especially in fields prescribed heterogeneous regions body. purpose this study was investigate effect on distributions patient geometry using Monte Carlo methods. Methods: code Geant4 used for all...