A5069460082- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Galectins and Cancer Biology
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cellular transport and secretion
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Signaling Pathways in Disease
Universidade Federal do Rio de Janeiro
2018-2025
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
2019-2021
National Institute of Science and Technology in Regenerative Medicine
2021
Hospital Universitário Clementino Fraga Filho
2017
Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising tools for treatment of several neurological and neurodegenerative diseases. MSCs release abundant extracellular vesicles (EVs) containing a variety biomolecules, including mRNAs, miRNAs, proteins. We hypothesized that EVs derived from human Wharton’s jelly would act mediators the communication between hMSCs neurons could protect hippocampal damage induced by Alzheimer’s disease-linked amyloid beta oligomers...
Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and distal optic nerve damage precedes retinal degeneration insult. Since we have shown reduced after crush Galectin-3 knockout (Gal-3 −/−) mice, decided to investigate whether Gal-3 −/− could relieve inflammation preserve both neurons structure retina following 8 weeks diabetes. Diabetes was induced 2-month-old male...
Purpose: Based on our preview evidence that reduced nuclear content of the transcription factor Myc-associated protein X (MAX) is an early event associated with degeneration retinal ganglion cells (RGCs), in present study, purpose was to test whether overexpression human MAX had a neuroprotective effect against RGC injury. Methods: Overexpression either or green fluorescent (GFP) retina achieved by intravitreal injections recombinant adenovirus-associated viruses (rAAVs). Lister Hooded rats...
A trauma to the mature central nervous system (CNS) often leads persistent deficits, due inability of axons regenerate after being injured. Increasing evidence suggests that pro-inflammatory and pro-apoptotic genes can present a major obstacle promoting neuroprotection retinal ganglion cells consequently succeed in axonal regeneration. This study evaluated effect absence galectin-3 (Gal-3) on (RGC) survival regeneration/degeneration optic nerve crush injury. Two weeks there was 2.6 fold...
Abstract Glaucoma is a neurodegenerative disorder characterized by the progressive functional impairment and degeneration of retinal ganglion cells (RGCs) their axons, leading cause irreversible blindness worldwide. Current management glaucoma based on reduction high intraocular pressure (IOP), one its most consistent risk factors, but disease proceeds in almost half patients despite such treatments. Several experimental models have been developed rodents, which present shortcomings as...
Gangliosides are glycosphingolipids abundantly expressed in the vertebrate nervous system, and classified into a-, b-, or c-series according to number of sialic acid residues. The enzyme GD3 synthase converts GM3 (an a-series ganglioside) GD3, a b-series ganglioside highly developing adult retina. present study evaluated visual system knockout mice (GD3s-/- ), morphologically functionally. absence b- series gangliosides retinas animals was confirmed by mass spectrometry imaging, which also...
Glaucoma, the second leading cause of blindness worldwide, is a heterogeneous group ocular disorders characterized by structural damage to optic nerve and retinal ganglion cell (RGC) degeneration, resulting in visual dysfunction interrupting transmission information from eye brain. Elevated intraocular pressure most important risk factor; thus, several models hypertension have been developed rodents either genetic or experimental approaches investigate causes effects disease. Among those,...
Glaucoma, the second leading cause of blindness worldwide, is a heterogeneous group ocular disorders characterized by structural damage to optic nerve and retinal ganglion cell (RGC) degeneration, resulting in visual dysfunction interrupting transmission information from eye brain. Elevated intraocular pressure most important risk factor; thus, several models hypertension have been developed rodents either genetic or experimental approaches investigate causes effects disease. Among those,...