A5076438174- Neurogenetic and Muscular Disorders Research
- Retinoids in leukemia and cellular processes
- Nerve injury and regeneration
- Developmental Biology and Gene Regulation
- Genomics and Chromatin Dynamics
- Hippo pathway signaling and YAP/TAZ
- Estrogen and related hormone effects
- Amyotrophic Lateral Sclerosis Research
- Cancer-related gene regulation
Instituto de Neurociencias
2021-2024
Universidad Nacional Autónoma de México
2022
Consejo Superior de Investigaciones Científicas
2021
Abstract Amyotrophic lateral sclerosis is a devastating neurodegenerative disease characterized by motor neuron death and distal axonopathy. Despite its clinical severity profound impact in the patients their families, many questions about pathogenesis remain still unclear, including role of Schwann cells axon‐glial signaling progression. Upon axonal injury, upregulation JUN transcription factor promotes cell reprogramming into repair phenotype that favors axon regrowth neuronal survival. To...
A connection between compromised asymmetric cell division (ACD) and tumorigenesis was proven some years ago using Drosophila larval brain neural stem cells, called neuroblasts (NBs), as a model system. Since then, we have learned that ACD does not always promote tumorigenesis, is an extremely well-regulated process in which redundancy substantially overcomes potential failures. Considering this, performed pilot RNAi screen NB lineages RasV12 scribble (scrib) mutant clones sensitized...